Idiopathic orbital inflammation following intravenous pamidronate

Acute uveitis following zoledronic acid infusion

“…proposed that these cytokines can cause extraocular muscle inflammation, resulting in orbital inflammatory disease. [5] The close temporal relationship between zoledronic acid infusion and the onset of ocular symptoms in our patient is in agreement with bisphosphonate-related ocular inflammation. Rapid response to drug withdrawal and topical steroid therapy also supports a drug-related etiology for this ocular process.…”

A 55‐year‐old woman with orbital inflammation

“…We performed a PubMed search using the terms “orbital inflammation” and “bisphosphonate” together, reviewed all references of pertinent articles, and identified 17 cases of acute bisphosphonate‐induced orbital inflammation published in the English literature (18–32) (Table 3). We also garnered additional cases from the National Registry of Drug‐Induced Ocular Side Effects (http://www.eyedrugregistry.com) located at the Casey Eye Institute in Portland, Oregon.…”

Sex Disparities in Neuro-Ophthalmologic Disorders

“…On a much smaller scale, bisphosphonates have been shown to cause ocular inflammation, such as anterior uveitis, conjunctivitis episcleritis, and scleritis, 151 and orbital inflammation in a small number of cases. [152][153][154][155][156][157][158][159][160][161][162][163][164] Bisphosphonates are primarily used for the treatment of osteoporosis. The use of bisphosphonates is increasing partly because of the increased use of aromatase inhibitors for the treatment of hormone-receptor-positive breast cancer in women and androgen-deprivation therapy for prostate cancer in men, which results in a reduction of bone-density.…”