Idiopathic Slipped Capital Femoral Epiphysis in Amish Children

Abstract

Although the children in this study were moderately heavy, they could not be classified as obese on the basis of weight-for-age or body-mass-index percentiles. The high prevalence of family members with slipped capital femoral epiphysis may reflect either a genetic or environmental component, or an interaction between genetics and environment (for example, work load or common chores requiring particular physical positions) in the Amish population.

Slipped Capital Femoral Epiphysis in Two Indian Brothers – The Inheritance of Slipped Capital Femoral Epiphysis Reviewed

“…1 In certain communities, there appears to be a particularly higher incidence of familial slipped capital femoral epiphysis. 1,2 There is also increasing interest in the possible association of this disease with various human leukocyte antigen types. [3][4][5][6] We report a pair of brothers who presented with slipped capital femoral epiphysis within a year.…”

“…These studies were done in stable populations where there may be inbreeding. 2 In his family studies, Rennie 1 suggested that autosomal dominant inheritance with variable penetrance was the likely mode of inheritance. However, he also noted a possibility of an autosomal recessive mode of inheritance in a smaller proportion of patients.…”