2002
DOI: 10.1016/s0009-2797(02)00052-2
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Idiosyncratic NSAID drug induced oxidative stress

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Cited by 129 publications
(88 citation statements)
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“…Similar dose of DIC has been shown to induce massive DNA fragmentations, increase the MDA level and to deplete the levels of GSH and SOD in rat liver [5]. The mechanism of DIC-induced ROS generation has been shown to involve peroxidase-catalyzed production of DIC radicals [9] and cytochrome P450-mediated bioactivation of DIC [4]. DIC, however, found to induced liver damage through various mechanisms such as covalent protein modification by reactive metabolites [6; 7; 8] and mitochondrial injury [10; 11].…”
Section: Discussionmentioning
confidence: 97%
“…Similar dose of DIC has been shown to induce massive DNA fragmentations, increase the MDA level and to deplete the levels of GSH and SOD in rat liver [5]. The mechanism of DIC-induced ROS generation has been shown to involve peroxidase-catalyzed production of DIC radicals [9] and cytochrome P450-mediated bioactivation of DIC [4]. DIC, however, found to induced liver damage through various mechanisms such as covalent protein modification by reactive metabolites [6; 7; 8] and mitochondrial injury [10; 11].…”
Section: Discussionmentioning
confidence: 97%
“…The formation of ROS has actually been implicated in indomethacin idiosyncratic toxicity such as bone marrow toxicity or hepatitis (Galati et al, 2002). ROS are inactivated by mitochondrial GSH.…”
Section: Discussionmentioning
confidence: 99%
“…Recent research has focused on the pro-oxidant property of some NSAIDs. For example, the horseradish peroxidasemediated oxidation of biomolecules like ascorbic acid, NADH and glutathione is promoted when these NSAIDs are added to the reac-tion medium (39). This pro-oxidant activity is based on the accelerated oxidation of these biomolecules by NSAID radicals and on the generation of reactive metabolites by the peroxidase-catalyzed reaction.…”
Section: Discussionmentioning
confidence: 99%