IF1 Protein Controls Aging Rate

Abstract

Dramatic rectal temperature decrease, in mice administered with a drug that specifically inhibits F1F0 ATP hydrolysis, suggests that F1F0 ATP hydrolysis is a major determinant of metabolic rate in vivo. Across twelve investigated species, less F1F0 ATP hydrolysis correlates with greater maximal lifespan. Specific drug inhibition of F1F0 ATP hydrolysis exerts potent anti-cancer activity in vitro.

DNA methylation rates scale with maximum lifespan across mammals

“…More generally, methylation dynamics have recently been used to develop epigenetic predictors of life-history traits 12 , to attempt to identify specific CpGs and associated genes involved in both ageing and longevity 13 . Findings such as these have led to the prediction that a scaling relationship might exist between methylation rates and maximum lifespan 14 .…”

“…to the prediction that a scaling relationship might exist between methylation rates and maximum lifespan 14 .…”