IFCN recommended standards for long-latency auditory event-related potentials. Report of an IFCN committee

Goodin, Douglas S.; Desmedt, John E.; Maurer, K.; Nuwer, Marc R.

doi:10.1016/0013-4694(94)90014-0

Cited by 100 publications

(65 citation statements)

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“…Among these, P300 wave reflects the speed of neuronal events underlying information processing, which is identified as a late cortical neuropsychological event reflecting activity of cognitive functions in humans. P300 combines cognition with electrophysiology [1][2][3].…”

Section: Introductionmentioning

confidence: 99%

Cognitive dysfunction in β‐thalassemia minor

et al. 2006

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Turkey b-thalassemia minor is a common, hereditary, and mostly symptomless disease. Previous studies have shown that lower hemoglobin values are associated with poorer cognitive functions. We aimed to evaluate the cognitive function in patients with b-thalassemia minor. Thirty-two male subjects with b-thalassemia minor and 32 sex-, age-, and education statusmatched healthy subjects were enrolled in the study. Blood tests and P300 potentials were carried out. P300 potential latency in all patients was significantly longer than those in the control group (337.63 ± 34.89 msec and 310.66 ± 14.30 msec, respectively; t 4.046, P < 0.001). The amplitudes of P300 in patient group were significantly lower than those in the control group (5.19 ± 3.59 lV and 9.81 ± 3.33 lV, respectively; t 5.349, P < 0.001). In this study, we have found that P300 potentials are adversely affected for cognitive functions in patients with b-thalassemia minor. Am. J. Hematol. 82:203-207, 2007. V V C 2006 Wiley-Liss, Inc.

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Section: Introductionmentioning

confidence: 99%

Cognitive dysfunction in β‐thalassemia minor

et al. 2006

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“…An average response was constructed for the standard and the target tones and the P300 wave was identified in the target response as a positive-(P2)-negative-(N2)-positive-(P3) complex at the range of 280 to 650 milliseconds, and maximal at the parietal site. 35 Latency was measured at Pz at the intersection of extrapolating lines from the ascending and descending portions of the P300 wave. If 2 P300 peaks were seen within the main peak, the whole peak was scored as a single peak.…”

Section: Methodsmentioning

confidence: 99%

“…If the peaks were distinct, the second peak was used to determine latency. 35 Peak amplitude was measured as the highest point of the P300 peak at the Pz electrode site and referred to the prestimulus baseline. The P300 recordings were performed by a trained technician blind to the hypotheses and the results of psychometric testing.…”

Section: Methodsmentioning

confidence: 99%

Prefrontal Dysfunction and Treatment Response in Geriatric Depression

Kalayam

Alexopoulos²

1999

Arch Gen Psychiatry

245

178

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“…Previous studies have demonstrated that the P300 amplitude is related to the updating of working memory content, and the P300 latency is related to the speed of stimulus evaluation (8,9). P300 is one of the most prominent positive peaks occurring around 300 ms after the infrequently presented target stimulus to which the subject is requested to respond by a certain task in the 'odd-ball paradigm' (10).…”

Section: Introductionmentioning

confidence: 99%

Utility of P300 auditory event related potential latency in detecting cognitive dysfunction in growth hormone (GH) deficient patients with Sheehan's syndrome and effects of GH replacement therapy

Gölgeli

Tanrıverdi

Süer

et al. 2004

European Journal of Endocrinology

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Objective: Impaired cognitive function has been demonstrated in adults with growth hormone (GH) deficiency (GHD) by using different neuropsychological tests. Despite several studies, present knowledge about the impact of GHD and GH replacement therapy (GHRT) on cognitive function is limited. P300 event-related potential (ERP) application is a well-established neurophysiological approach in the assessment of cognitive functions including the updating of working memory content and the speed of stimulus evaluation. GHD is a well-known feature of Sheehan's syndrome and cognitive changes due to GHD and the effects of GHRT remain to be clarified. The present study was designed to investigate the effects of GHD and 6 months of GHRT on cognitive function in patients with Sheehan's syndrome by using P300 latency. Design and methods: The study comprised 14 patients with Sheehan's syndrome (mean age, 49.5^7.8 years) and 10 age-, education-and sex-matched healthy controls. With hormone replacement therapy, basal hormone levels other than GH were stable before enrollment and throughout the GHRT. The diagnosis of GH deficiency was established by insulin-tolerance test (ITT), and mean peak level of GH in response to insulin hypoglycemia was 0.77^0.35 mIU/l. Treatment with GH was started at a dose of 0.45 IU (0.15 mg)/day in month 1, was increased to 0.9 IU (0.30 mg)/day in month 2 and was maintained at 2 IU (0.66 mg)/day. Initially baseline auditory ERPs in patients and controls were recorded at frontal (Fz), central (Cz), and parietal (P3 and P4) electrode sites. In the patient group, ERPs were re-evaluated after 6 months of GH replacement therapy. During each session P300 amplitude and latency were measured. Results: Mean serum insulin-like growth factor-I (IGF-I) concentration in the patient group before GHRT was 23^13 ng/ml. After 6 months of GH therapy mean IGF-I significantly increased to an acceptable level, 234^71 ng/ml (P , 0.05). The mean latencies (at all electrode sites) of the patients before GHRT were found to be significantly prolonged when compared with those of normal controls (P , 0.05). After 6 months of GHRT mean P300 latencies (at all electrode sites) were decreased significantly when compared with latencies before treatment (P , 0.05). Conclusions: The present study, using P300 ERP latencies, therefore suggests an impairment of cognitive abilities due to severe GHD in patients with Sheehan's syndrome and an improvement of cognitive function after 6 months of physiological GHRT. Moreover, this was a novel application of P300 ERP latencies in cognitive function detection in patients with GHD. Further studies with different patient groups need to be done to assess the clinical use of this electrophysiological method in the diagnosis of cognitive dysfunction due to GHD. European Journal of Endocrinology 150 153-159

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IFCN recommended standards for long-latency auditory event-related potentials. Report of an IFCN committee

Cited by 100 publications

References 0 publications

Cognitive dysfunction in β‐thalassemia minor

Cognitive dysfunction in β‐thalassemia minor

Prefrontal Dysfunction and Treatment Response in Geriatric Depression

Utility of P300 auditory event related potential latency in detecting cognitive dysfunction in growth hormone (GH) deficient patients with Sheehan's syndrome and effects of GH replacement therapy

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