IFN-tau: A novel subtype I IFN1. Structural characteristics, non-ubiquitous expression, structure-function relationships, a pregnancy hormonal embryonic signal and cross-species therapeutic potentialities

Martal, J.; Chêne, N.; Huynh, L.; L'Haridon, R.; Reinaud, Pierrette; Guillomot, Michel; Charlier, Madia; Charpigny, S.Y.

doi:10.1016/s0300-9084(99)80029-7

Cited by 92 publications

(65 citation statements)

References 170 publications

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“…The striking correlation between the temporal changes in SOCS1 and SOCS2 genes expression (present study) and the known secretion profile of IFN (Roberts et al 1992, Martal et al 1998) led us to investigate if this locally acting signal could actually modulate the expression of the SOCS genes. The expression of the SOCSs 1, 2 and 3 mRNA was stimulated by a single intrauterine injection of roIFN in cyclic ewes after 2 h. This stimulation is rapid and transient as expected from what was reported in other biological systems where SOCS are known as cytokineinducible immediate early genes (Yoshimura et al 1995, Endo et al 1997, Krebs & Hilton 2000.…”

Section: Discussionmentioning

confidence: 70%

“…Pregnancy as well as conceptus-induced SOCS2 and SOCS1 display a similar regulation, thereby suggesting that SOCS2 can also take part to the negative regulation of IFN signal transduction. Given the various biological properties of IFN (Roberts et al 1992, Martal et al 1998, further studies about SOCS 1, 2 and 3 are definitely required to establish their respective contribution in the negative regulation of the IFN signalling pathway.…”

Section: Discussionmentioning

confidence: 99%

“…For these SOCS genes, the regulation beyond day 20 of pregnancy cannot result from IFN , whose secretion ends at days 20-21 of pregnancy (Roberts et al 1992, Martal et al 1998. In addition to the persisting endometrial production of cytokines such as LIF, CSF or interleukins 2, 4 or 6 beyond the implantation stage (Martal et al 1997, Rahman et al 2004, ligands and receptors of the ovine placental lactogen (PL)/growth factor (GH) and insulin-like growth factor (IGF) systems are also expressed when the placentation starts.…”

Section: Discussionmentioning

confidence: 99%

“…IFN is secreted exclusively by the ovine trophectoderm from days 10 to 22 after mating. It is not detected in the maternal serum and acts in a paracrine fashion on the endometrium to prevent the increase of oxytocin and oestrogen receptors, thereby abrogating the luteolytic mechanism (Martal et al 1998). IFN is a member of the type I IFN family, binds to type I IFN receptors (IFNARs), signals through the Janus kinase/ signal transduction and activators of transcription (JAK/ STAT) pathway and regulates a set of IFN-responsive genes including STATs 1 and 2, 2-macroglobulin, IFN regulatory factors (IRFs) 1 and 9, ISG17 Mx protein and 2 ,5 -oligoadenylate synthetase (Spencer & Bazer 2002).…”

Section: Introductionmentioning

confidence: 99%

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Suppressor of cytokine signalling (SOCS) genes are expressed in the endometrium and regulated by conceptus signals during early pregnancy in the ewe

Sandra

Bataillon²,

Roux³

et al. 2005

Journal of Molecular Endocrinology

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It is established that the conceptus-endometrium dialogue involves cytokines, growth factors and hormones. Given the crucial functions of the suppressor of cytokine signaling (SOCS) family proteins in cytokine signalling, we analyzed the expression and the regulation of CIS and SOCSs 1-3 transcripts during early pregnancy in the ovine endometrium. An overall stimulation of the SOCS transcripts was described in the pregnant ewes with two specific patterns. Unilaterally pregnant ewes confirmed the conceptus-produced factors as regulators of the SOCSs 1-3 expression at day 16 of pregnancy. Intrauterine injection of recombinant ovine interferon (IFN ) in cyclic ewes stimulated the expression of the SOCS mRNA with various potencies, therefore suggesting that the SOCS could take part in the negative regulation of the IFN signalling pathway.

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Section: Discussionmentioning

confidence: 70%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Suppressor of cytokine signalling (SOCS) genes are expressed in the endometrium and regulated by conceptus signals during early pregnancy in the ewe

Sandra

Bataillon²,

Roux³

et al. 2005

Journal of Molecular Endocrinology

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show abstract

“…It plays an essential role for maternal recognition of pregnancy, particularly allowing the maintenance of the corpus luteum and its progesterone secretion (Spencer et al 2004). Indeed, intrauterine injections of recombinant IFN- extend the progesterone secretion by inhibiting pulsatile uterine secretion of luteolytic prostaglandin F-2 (Martal et al , 1998Ott et al 1993;Meyer et al 1995). IFN- downregulates the expression of endometrial oxytocin receptors concentrations (Spencer and Bazer 1996;Mann et al 1999).…”

Section: Introductionmentioning

confidence: 99%

Relationship Between IFN-t Production by Bovines Embryos Derived Ex Vivo and Completely Produced In Vitro

Neira¹,

Tainturier²,

Martal³

2011

Artificial Insemination in Farm Animals

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Fetal–Maternal Immunological Relationships

Chaouat

2012

Encyclopedia of Life Sciences

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Despite inheriting half of its genetic material from its father, the fetoplacental unit is not rejected by the maternal immune system because of a unique immunological relationship with the mother. Despite maternal immune recognition of the conceptus as evidenced by alloantibodies, unlike for conventional allografts, the immune response is spared, cytotoxic effectors being downregulated or suppressed, whereas several cytokinic responses, including inflammatory ones, are used or even provoked for their preimplantation or later on ‘immunotrophic’ effects. This unique relationship is partly due to the peculiar antigen expression in the placenta, culminating in humans with the sole expression of human leucocyte antigen C (HLA‐C) and monomorphic HLA‐G on invading cytotrophoblasts and also many immunoregulatory pathways, with special emphasis presently put on regulatory T cells. Moreover, uterine natural killer (uNK) cells are a distinct, specialised NK subset, endowed with immunoregulatory and angiogenic properties, necessary for local (spiral) arteries development. Consequences for abortion eclampsia are discussed, as well as antibody‐induced fetal haemolytic disease. Key Concepts: The fetus is usually seen as an allograft in mother's womb, which should be rejected by the maternal immune system. Pregnancy induces systemic modifications in the maternal immune system but these do not really account for fetal survival. Recognition of the ‘foreign’ nature of the fetus is good and even sometimes required for successful pregnancy. Placenta acts as a barrier between the fetus and maternal cells. Uterine natural killer cells are not endowed with the same properties as the ones found in peripheral blood. One of the keys to fetal survival is the peculiar expression of MHC antigens in the placenta, including in human the expression of a nonpolymorphic antigen, HLA‐G, in membrane bound and soluble forms both endowed with immunoregulatory properties. Uterine natural killer cells control local uterine angiogenesis. The placenta bathes in/secretes immunotregulatory materials. Regulatory T cells mitigate the effects of allorecognition by maternal immune system in placental mammals. Allopregnancy is a Th2 phenomenon. In variance with MHC antigens, red blood cells antigens can induce maternal antibodies which can cross the placenta, and destroy in utero fetal red blood cells.

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IFN-tau: A novel subtype I IFN1. Structural characteristics, non-ubiquitous expression, structure-function relationships, a pregnancy hormonal embryonic signal and cross-species therapeutic potentialities

Cited by 92 publications

References 170 publications

Suppressor of cytokine signalling (SOCS) genes are expressed in the endometrium and regulated by conceptus signals during early pregnancy in the ewe

Suppressor of cytokine signalling (SOCS) genes are expressed in the endometrium and regulated by conceptus signals during early pregnancy in the ewe

Relationship Between IFN-t Production by Bovines Embryos Derived Ex Vivo and Completely Produced In Vitro

Fetal–Maternal Immunological Relationships

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