IFN-γ Attenuates Eosinophilic Inflammation but Is Not Essential for Protection against RSV-Enhanced Asthmatic Comorbidity in Adult Mice

Muralidharan, Abenaya; Uddin, Bashir; Bauer, Christopher; Wu, Wenzhe; Bao, Xiaoyong; Sun, Keer

doi:10.3390/v14010147

Cited by 4 publications

(5 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Our findings suggest that the degree of IFN-γ reduction depends on the severity of asthma. Our data are in line with the results of other researchers who have demonstrated reduced levels of IFN-γ in frequently ill children [24] and in mice with asthma [14,15,23]. In their work, they show how the levels of IFN-γ change under the influence of medicines, which leads to an improvement in the clinical and laboratory parameters of patients with asthma.…”

Section: педіатрія / Pediatricssupporting

confidence: 92%

See 1 more Smart Citation

IMBALANCE BETWEEN IL-2, IL-4 AND IFN-γ AS a MARKER OF SUSTAINABILITY OF PARTLY CONTROLLED ASTHMA IN CHILDREN

Makieieva,

Andrushchenko

2023

VPBM

View full text Add to dashboard Cite

Connection of the publication with planned research works.This article was carried out within the framework of the Department of Paediatrics № 2 of Kharkiv National Medical University «Medical and biological aspects of adaptation of children with somatic pathology in modern conditions. Prediction of asthma control in children taking into account inflammatory markers and the state of the airway barrier of the lungs». State registration number 0120U102471.Introduction.Asthma is one of the most common noncommunicable diseases that significantly affects the quality of life. Globally, asthma is the 16th leading cause of disability. Around 300 million people worldwide suffer from asthma, and it is likely that another 100 million people may be affected by it by 2025 [1, 2, 3]. The disease usually first appears before the age of 6 years [4,5] and has a significant impact on quality of life in adulthood [6,7,8].Asthma is one of the most common chronic inflammatory diseases of the respiratory tract. It is caused by a significant number of cellular elements and mediators of inflammation, which leads to bronchial hyperreactivity [9].The obligatory pathogenetic mechanism of asthma is a chronic inflammatory process caused by specific immunological (sensitisation and allergy) or nonspecific mechanisms. This process is not limited to the bronchial tree but is systemic in nature [10].The formation of inflammation is closely related to the action of cytokines. Proinflammatory interleukins

show abstract

Section: педіатрія / Pediatricssupporting

confidence: 92%

“…Researchers have also shown that elevated levels of IL-2 are associated with both acute and chronic respiratory tract pathologies [23].…”

Section: педіатрія / Pediatricsmentioning

confidence: 99%

IMBALANCE BETWEEN IL-2, IL-4 AND IFN-γ AS a MARKER OF SUSTAINABILITY OF PARTLY CONTROLLED ASTHMA IN CHILDREN

Makieieva,

Andrushchenko

2023

VPBM

View full text Add to dashboard Cite

show abstract

“…In one report, type 1 cytokines including IL-6, IL-1β, and interferon-gamma (IFN- γ ) levels were systemically elevated in SARS-CoV-2 infected patients ( 9 ). IFN- γ is also known to attenuate respiratory eosinophilic inflammation ( 17 ). These findings suggest that SARS-CoV-2 infection may have contributed to the relief of ECRS.…”

Section: Discussionmentioning

confidence: 99%

Improvement of eosinophilic chronic rhinosinusitis after infection with severe acute respiratory syndrome corona virus 2 during dupilumab therapy: A case report

Koike-Ieki

Kagoya²,

Toma-Hirano³

et al. 2023

Front. Allergy

View full text Add to dashboard Cite

Eosinophilic chronic rhinosinusitis (ECRS) is an intractable type 2 inflammatory disease of the paranasal sinuses that persists even after endoscopic sinus surgery (ESS) and systemic corticosteroid therapy. Dupilumab, a monoclonal antibody against the shared receptor components of interleukin (IL)-4 and IL-13, is a novel and effective treatment option for ECRS. Herein, an atypical case of ECRS that improved after infection with severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) during dupilumab therapy is reported. A 40-year-old man with a history of ESS for ECRS visited our hospital with complaints of nasal congestion and dysosmia. Nasal endoscopy revealed bilateral nasal polyps occupying the nasal cavity. Computed tomography (CT) revealed a soft tissue density lesion filling all sinuses on both sides. Based on these findings, ECRS recurrence was confirmed; however, 3 years of subsequent corticosteroid therapy did not improve disease activity. Accordingly, dupilumab therapy was initiated, although 6 months of therapy resulted in only slight improvement in ECRS. Eight months after the initiation of dupilumab therapy, the patient was infected with SARS-CoV-2; thereafter, he noticed an improvement in smell. Nasal endoscopy and sinus CT revealed a marked reduction in nasal polyps and soft tissue density lesions of the sinuses, respectively. With continued dupilumab therapy, no re-exacerbation of ECRS was confirmed at the 6-month follow-up from SARS-CoV-2 infection. Currently, there are no reports describing the impact of SARS-CoV-2 infection on ECRS. As such, careful follow-up and accumulation of cases are necessary.

show abstract

“…Існують наукові роботи, які показують зниження рівнів γ-інтерферону у дітей, що часто хворіють [33]. Доведено, що зниження рівнів γ-інтерферону відповідало еозінофільному типу запалення у дорослих мишей з астмою [34]. Виявлені в нашій роботі знижені рівні γ-інтерферону в пацієнтів з wheezing, не пов'язаного з вірусними тригерами.…”

Section: показникиunclassified

“…При цьому статистично достовірними були виявлені зв'язки у пацієнтів з лікар-діагностованою астмою. Подібні зв'язки були продемонстровані в сучасних наукових роботах при вивченні хронічного запалення при астмі у мишей [27,34]. Дане дослідження підтверджує вірогідний зворотній зв'язок у дітей з хронічним алергійним запаленням.…”

Section: показникиunclassified

Levels of Il-4 and Γ- Interferon in Children’s Blood Serum as Predictors of Asthma Formation

Makieieva,

Andrushchenko,

Malakhova

et al. 2023

Neonatol. hìr. perinat. med.

View full text Add to dashboard Cite

Introduction. The prevalence of asthma continues to increase every year. Asthma is the leading chronic disease. Infl ammation,both acute and chronic, is closely related to the action of cytokines (pro- and anti-infl ammatory). T-helper 2 lymphocytesrelease IL-4, which triggers the production of immunoglobulin E (IgE) antibodies, which set the stage for allergy and activateinfl ammatory cells. The regulators of this process are T helper-1 lymphocytes, which produce cytokines (IFN-gamma) thatsuppress Th-2 activity. Disturbances in the ratio of Th-1/Th-2 lymphocyte clones are a subject of debate in the early detectionof asthma and the prediction of the development of this disease.The aim of the study was to evaluate the levels of IL-4 and γ-interferon in the blood serum of children with transient wheezeand asthma..Material and methods. 121 children were included in the study. The patients were divided into groups: group 1 – childrenwith transient wheezing (TW) (n = 81), group 2 – children with doctor- diagnosed asthma (DDA) (n = 15), group 3 – healthychildren (n = 25).IL-4 and γ-interferon in blood serum were analyzed by ELISA using commercial kits (human IL-4 and human γ-interferon“Vector Best- Ukraine”). Data were analyzed using Statsoft Statistica version 8 (Tulsa, OK) and the MedCalc version 17.2statistical program.The planned clinical trials were conducted after obtaining the approval of the local ethics committee (date: February 1, 2015;number: 2015/01) and were conducted in accordance with the principles of the Declaration of Helsinki, as amended in October 2013.This article was conducted within the framework of the Department of Pediatrics No. 2 of Kharkiv National MedicalUniversity «Medical and biological aspects of adaptation of children with somatic pathology to modern conditions. Predictionof asthma control in children taking into account infl ammatory markers and the state of the airway barrier of the lungs» (stateregistration number 0120U102471).Results. It was found that in children of the fi rst and second groups, in the midst of clinical manifestations of wheezing, IL-4levels signifi cantly increased and serum γ-interferon levels decreased. The highest levels of IL-4 and the lowest levels of serumγ-interferon were found in patients with DDA.Serum levels of IL-4 above 15.33 pg/mL and γ-interferon below 98.62 pg/mL in children with wheezing episodes may beconsidered as a possible indicator of asthma development.Conclusions. Serum IL-4 and γ-interferon are involved in the regulation of allergic infl ammatory processes in the body.A statistically signifi cant increase in IL-4 levels and a decrease in γ-interferon levels in the blood serum of patients with asthmais likely to indicate the development of a chronic form of infl ammation.

show abstract

IFN-γ Attenuates Eosinophilic Inflammation but Is Not Essential for Protection against RSV-Enhanced Asthmatic Comorbidity in Adult Mice

Cited by 4 publications

References 34 publications

IMBALANCE BETWEEN IL-2, IL-4 AND IFN-γ AS a MARKER OF SUSTAINABILITY OF PARTLY CONTROLLED ASTHMA IN CHILDREN

IMBALANCE BETWEEN IL-2, IL-4 AND IFN-γ AS a MARKER OF SUSTAINABILITY OF PARTLY CONTROLLED ASTHMA IN CHILDREN

Improvement of eosinophilic chronic rhinosinusitis after infection with severe acute respiratory syndrome corona virus 2 during dupilumab therapy: A case report

Levels of Il-4 and Γ- Interferon in Children’s Blood Serum as Predictors of Asthma Formation

Contact Info

Product

Resources

About