IFNγ enhances cytotoxic efficiency of the cytotoxic T lymphocytes against human glioma cells

Shao, Shengwen; Risch, Eric; Burner, Danielle; Lu, Lingeng; Minev, Boris; Ma, Wenxue

doi:10.1016/j.intimp.2017.04.003

Cited by 22 publications

(18 citation statements)

References 27 publications

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“… 5 , 6 , 42 T-cell activation status was positively associated with breast cancer patients’ OS. 32 , 43 Besides, PD-L1+ tumor-infiltrating lymphocytes status showed an independent favorable prognostic value in patients with inflammatory breast cancer, suggesting that immune checkpoint immunotherapy should be explored and correlated with prognosis in these patients. 44 …”

Section: Discussionmentioning

confidence: 99%

Increased derived neutrophil-to-lymphocyte ratio and Breast Imaging-Reporting and Data System classification predict poor survival in patients with non-distant metastatic HER2+ breast cancer treated with neoadjuvant chemotherapy

Li¹,

Shao²,

Bai³

et al. 2018

CMAR

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IntroductionThe prognostic role of the derived neutrophil-to-lymphocyte ratio (dNLR) in human patients with HER2+ breast cancer is not well understood. Here, we aimed to investigate the prognostic significance of dNLR in patients with HER2+ breast cancer undergoing neoadjuvant chemotherapy.MethodsA total of 310 patients with non-distant metastatic HER2+ breast cancer who had received neoadjuvant chemotherapy in our hospital from May 2006 to November 2013 were retrospectively included in this study. Kaplan–Meier curves were used to assess overall survival (OS) and disease-free survival (DFS). The Cox regression model was used to evaluate the prognostic value of dNLR and Breast Imaging-Reporting and Data System (BI-RADS) classification, as well as other clinicopathological parameters in patients with HER2+ breast cancer treated with neoadjuvant chemotherapy.ResultsWe found that dNLR prior to treatment was positively correlated with tumor size, tumor stage, lymphovascular invasion, and histological grade (P<0.05). The median OS of patients with high dNLR and low dNLR were 44.2 and 69.9, respectively (P<0.001), and the median DFS of patients with high dNLR and low dNLR were 15.3 and 22.1 months, respectively (P<0.001). Multivariate analysis showed that dNLR was an independent risk factor for OS (HR =1.726; 95% CI: 1.072–2.662; P=0.009) and DFS (HR =1.658; 95% CI: 1.125–2.426; P=0.026). Moreover, increased BI-RADS classification independently predicted short OS (HR =1.609; 95% CI: 1.216–2.351; P=0.015) and DFS (HR =1.925; 95% CI: 1.526–2.635; P=0.021).ConclusiondNLR prior to treatment and BI-RADS classification are independent prognostic factors in patients with HER2+ breast cancer receiving neoadjuvant chemotherapy.

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Section: Discussionmentioning

confidence: 99%

Increased derived neutrophil-to-lymphocyte ratio and Breast Imaging-Reporting and Data System classification predict poor survival in patients with non-distant metastatic HER2+ breast cancer treated with neoadjuvant chemotherapy

Li¹,

Shao²,

Bai³

et al. 2018

CMAR

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show abstract

“… 6 , 7 , 31 Activation status of T cells was positively associated with the OS in patients with breast cancer. 32 , 33 Additionally, it has shown that status of tumor-infiltrating lymphocyte that expressing the pro grammed cell death 1-ligand 1 was an favorable independent predictor of prognosis for patients with inflammatory breast cancer, suggesting that immune checkpoint immunotherapy should be explored and correlated with prognosis in these patients. 34 …”

Section: Discussionmentioning

confidence: 99%

Prognostic role of derived neutrophil-to-lymphocyte ratio in surgical triple-negative breast cancer

Ren¹,

Yin²,

He³

et al. 2018

CMAR

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IntroductionThe role of derived neutrophil-to-lymphocyte ratio (dNLR) in predicting the prognosis of patients with triple-negative breast cancer (TNBC) has not been well studied. Here, we attempted to investigate the significance of dNLR in predicting the prognosis of patients with surgical (nonmetastatic) TNBC.MethodsA total of 281 patients diagnosed with surgical TNBC in The First Affiliated Hospital of University of Science and Technology of China from February 2005 to March 2015 were retrospectively included in this study. Kaplan–Meier curve analysis was used to assess the disease-free survival (DFS) and overall survival (OS). We used Cox regression model to assess the prognostic significance of pretreatment dNLR and other clinicopathological parameters in TNBC patients.ResultsThe median DFS in TNBC patients who had low dNLR and high dNLR was 28.9 and 15.1 months (P<0.001), respectively, whereas the median OS in patients who had low dNLR and high dNLR was 71.2 and 42.3 months (P<0.001), respectively. In patients aged ≤50 years and with invasive ductal carcinoma, a low dNLR predicted better DFS and OS compared with a high dNLR. Multivariate analysis demonstrated that the increased dNLR was a risk factor of poor DFS (HR=1.90, 95% CI: 1.52–2.46, P=0.007) and OS (HR=2.56, 95% CI: 1.69–3.58, P=0.001).ConclusionPretreatment dNLR is an independent factor of prognosis for TNBC patients, which potentially allows clinical doctors to improve outcomes of patients with high dNLR by treating with aggressive therapy, such as high-dose adjuvant chemotherapy and radiotherapy.

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“…Crosspresentation of tumor antigen to naïve CD8 + T cells is carried out by the dendritic cells. In addition, radiation-induced interferon-γ upregulates the class I major-histocompatibility-complex (MHC) expression, allowing T cells to recognize tumor cell targets and in ltrate into tumors [10,11]. Interferon-γ is also secreted from these recruited T cells to inhibit the tumor cell cycle.…”

mentioning

confidence: 99%

Time-Sequential Change in Immune-Related Gene Expression After Irradiation in Glioblastoma: Next-Generation Sequencing Analysis

Kim

Seo

et al. 2020

Preprint

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The time-sequential change in immune-related gene expression of the glioblastoma cell line after irradiation was evaluated to speculate the effect of combined immunotherapy with radiotherapy. The U373 MG glioblastoma cell line was irradiated with 6 Gy single dose. Next-generation sequencing (NGS) transcriptome data was generated before irradiation (control), and at 6, 24, and 48 hours post-irradiation. Immune-related pathways were analyzed at each time period. The same analyses were also performed for A549 lung cancer and U87 MG glioblastoma cell lines. Western blotting confirmed the programmed death-ligand 1 (PD-L1) expression levels over time. In the U373 MG cell line, neutrophil-mediated immunity, type I interferon signaling, antigen cross-presentation to T cell, and interferon-γ signals began to increase significantly at 24 hours and were upregulated until 48 hours after irradiation. The results were similar to those of the A549 and U87 MG cell lines. Without T cell infiltration, PD-L1 did not increase even with upregulated interferon-γ signaling in cancer cells. In conclusions, In the glioblastoma cell line, immune-related signals were significantly upregulated at 24 hours after irradiation. Therefore, the time interval between daily radiotherapy might not be enough to expect full immune responses by combined immune checkpoint inhibitors and newly infiltrating immune cells after irradiation.

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IFNγ enhances cytotoxic efficiency of the cytotoxic T lymphocytes against human glioma cells

Cited by 22 publications

References 27 publications

Increased derived neutrophil-to-lymphocyte ratio and Breast Imaging-Reporting and Data System classification predict poor survival in patients with non-distant metastatic HER2+ breast cancer treated with neoadjuvant chemotherapy

Increased derived neutrophil-to-lymphocyte ratio and Breast Imaging-Reporting and Data System classification predict poor survival in patients with non-distant metastatic HER2+ breast cancer treated with neoadjuvant chemotherapy

Prognostic role of derived neutrophil-to-lymphocyte ratio in surgical triple-negative breast cancer

Time-Sequential Change in Immune-Related Gene Expression After Irradiation in Glioblastoma: Next-Generation Sequencing Analysis

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