IgA Antigliadin Antibodies in Celiac and Inflammatory Bowel Disease

Köninckx, Carmen Ribes; Giliams, J. P.; Polanco, Isabel; Peña, A. S.

doi:10.1097/00005176-198411000-00006

Cited by 58 publications

(36 citation statements)

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“…This study confirms that anti-GL IgA are found in serum from most patients with active CD, but also in serum from some patients with unrelated diseases [3][4][5][6]. However, the molecular size of these serum IgA Abs is different in the two groups, 57% being plgA in active CD compared to only 17% in other patients.…”

Section: Discussionsupporting

confidence: 82%

“…Patients usually have ele vated levels of serum antibodies (Abs) to gliadin (GL), which is the ethanol-soluble fraction of gluten [2]. IgA Abs are relatively specific for active CD, but they are occasionally detected in serum from patients with a variety of other intestinal disorders including Crohn's disease, cow's milk-sensitive enteropathy and intestinal infections with parasites [3][4][5][6]. When CD patients are treated with a gluten-free diet (GFD), IgA Abs titers fall rapidly, providing a criterion of ad herence to the GFD [7,8],…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

IgA Immune Response Patterns to Gliadin in Serum

Mascart‐Lemone¹,

Cadranel²,

Broeck³

et al. 1988

Int Arch Allergy Immunol

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The incidence, titer and molecular size of anti-gliadin (GL) IgA were analyzed in sera from children with celiac disease (CD, n = 66), hospitalized control children (n = 64) and children with other malabsorption disorders (n = 103). Anti-GL IgA was assessed by solid-phase radioimmunoassay, and its molecular size was analyzed by sucrose density gradient ultracentrifugation. The median anti-GL IgA titer was significantly higher in untreated CD than in the other groups, with some overlap. Whereas 57% of anti-GL IgA were polymeric IgA (pIgA) in acute CD, only 17% were pIgA in children with other malabsorption disorders. These anti-GL pIgA consisted mainly of dimers with in some children, a low proportion of anti-GL secretory IgA (SIgA). A large proportion of anti-GL pIgA was associated with high total serum IgA. After the onset of a gluten-free diet (GFD), anti-GL pIgA disappeared more quickly from serum than mlgA. During the gluten challenge test, anti-GL IgA comprised 20% pIgA when they reappeared in serum, but 59% pIgA at the end of the test. The presence of anti-GL pIgA in serum seems related to chronic exposure to gluten of CD patients with a flat intestinal mucosa. These serum pIgA antibodies could result from a spillover from the intestinal mucosal synthesis into the circulation.

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Section: Discussionsupporting

confidence: 82%

Section: Introductionmentioning

confidence: 99%

IgA Immune Response Patterns to Gliadin in Serum

Mascart‐Lemone¹,

Cadranel²,

Broeck³

et al. 1988

Int Arch Allergy Immunol

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“…These antibodies may be present in inflammatory bowel disease [97], collagen vascular disease [98] and in many healthy people [99]. However, combining AGAs, with other serologic tests increases the sensitivity of the serologic tests [100], thus increasing the overall detection rate of CD.…”

Section: Diagnosis Of CDmentioning

confidence: 99%

Mechanisms underlying celiac disease and its neurologic manifestations

Green

Alaedini

Sander

et al. 2005

CMLS, Cell. Mol. Life Sci.

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The extra-intestinal manifestations of celiac disease (CD), including ataxia and peripheral neuropathy, are increasingly being recognized as the presenting symptoms of this autoimmune disease. Although there is a greater understanding of the pathogenesis of the intestinal lesions in CD the mechanisms behind the neurologic manifestations of CD have not been elucidated. In this article, the authors review the cellular and molecular mechanisms behind the histopathologic changes in the intestine, discuss the presentation and characteristics of neurologic manifestations of CD, review the data on the mechanisms behind these manifestations, and discuss the diagnosis and treatment of CD. Molecular mimicry and intermolecular help may play a role in the development of neurologic complications.

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“…In the last few years several articles on gliadin antibody determination as a screening test for CD have appeared. Most authors agree that IgG antibody (IgG AB) determinations are sensitive but not pathognomonic and IgA AB are more specific but are less sensitive [4,12,13,15,18,23,25,27,30,31,33,34]. IgE AB determinations have rarely been performed and have given contradictory results [1,3,13,22,28].…”

Section: Offprint Requests To: a Bttrgin-wolffmentioning

confidence: 99%

IgG, IgA and IgE gliadin antibody determinations as screening test for untreated coeliac disease in children, a multicentre study

et al. 1989

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The diagnostic value of gliadin IgG, IgA and IgE antibody (AB) determinations using the fluorescent immunosorbent test was examined in 586 children with malabsorptive disorders and/or failure to thrive. All patients underwent jejunal biopsy and were on a gluten-containing diet. IgG AB were found in all patients (331/331) with untreated coeliac disease (CD) in our study, but IgA AB in only 295/331 (89%). Therefore a screening test based only on IgA AB determinations is not recommended. By contrast, 203 (80%) of 255 children with other malabsorptive disorders had no gliadin AB, 43 (16.5%) had only IgG AB and only 9 (3.5%) had IgG and IgA AB. IgE AB proved to be of no additional value as a diagnostic tool because they were found in a quarter of the children without CD. Statistical evaluation of combined IgG and IgA AB determination showed at least 96% sensitivity and a specificity of 97%. The subjective ("Bayesian") probability that an actual patient with a given AB test result has CD, is considered: a patient very probably has CD in the case of positive IgG and IgA AB, and no CD in the case of a negative AB result. In the case of negative IgA AB but positive IgG AB the physician's judgement ("prior probability") influences the ("posterior") probability of CD for an actual patient. In contrast to IgG AB, IgA AB decline rapidly after the introduction of a gluten-free diet and may be used for diet control after diagnosis.(ABSTRACT TRUNCATED AT 250 WORDS)

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IgA Antigliadin Antibodies in Celiac and Inflammatory Bowel Disease

Cited by 58 publications

References 0 publications

IgA Immune Response Patterns to Gliadin in Serum

IgA Immune Response Patterns to Gliadin in Serum

Mechanisms underlying celiac disease and its neurologic manifestations

IgG, IgA and IgE gliadin antibody determinations as screening test for untreated coeliac disease in children, a multicentre study

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