2018
DOI: 10.1007/s10549-018-4941-5
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IgA Fc-folate conjugate activates and recruits neutrophils to directly target triple-negative breast cancer cells

Abstract: These findings support the hypothesis that an IgA Fc-folate conjugate can destroy TNBC cells by eliciting PMN-mediated ADCC.

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Cited by 7 publications
(6 citation statements)
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“…Evidence exists that serum IgA contributes to autoimmune diseases, such as inflammatory bowel disease 6,7 , autoimmune skin blistering diseases 8,9 , or rheumatoid arthritis (RA) [10][11][12] as well as to transplant rejection 13 . In addition, IgA has gained interest as a therapeutic antibody against cancer cells, as it activates neutrophilmediated antibody-dependent cellular cytotoxicity better than IgG 14,15 .…”
mentioning
confidence: 99%
“…Evidence exists that serum IgA contributes to autoimmune diseases, such as inflammatory bowel disease 6,7 , autoimmune skin blistering diseases 8,9 , or rheumatoid arthritis (RA) [10][11][12] as well as to transplant rejection 13 . In addition, IgA has gained interest as a therapeutic antibody against cancer cells, as it activates neutrophilmediated antibody-dependent cellular cytotoxicity better than IgG 14,15 .…”
mentioning
confidence: 99%
“…However, in this study, it is unclear if the suppression can be attributed to IgA + plasmocytes or IgA alone (Shalapour et al, 2015). By contrast, IgA shows a therapeutic potential against cancer cells, since it activates neutrophil-mediated antibodydependent cellular cytotoxicity better than IgG (Frontera et al, 2018;Steffen et al, 2020). It should be highlighted though that confirmation that immunoglobulins produced by nonlymphoid cells are functional is still pending, since studies on whether affinity-matured antibodies from these cells are capable of binding to antigens are not yet available.…”
Section: Immunoglobulin Genesmentioning
confidence: 71%
“…Anti-FRA IgG antibodies such as MORAB-003 (Farletuzumab) have also been used to target ovarian cancer in patients, although with limited success (107). In a recent study, Frontera et al (108) demonstrated that an IgA Fc-folate conjugate can bind strongly to FRA receptors on TNBC stimulating neutrophils (PMN)-mediated cell killing. PMNs are heavily present in breast tumors and exert cytotoxic action against tumor cells, representing a possible tool against TNBC (109).…”
Section: Folatementioning
confidence: 99%
“…In a recent study, Frontera et al ( 108 ) demonstrated that an IgA Fc-folate conjugate can bind strongly to FRA receptors on TNBC stimulating neutrophils (PMN)-mediated cell killing. PMNs are heavily present in breast tumors and exert cytotoxic action against tumor cells, representing a possible tool against TNBC ( 109 ).…”
Section: Bioactive Food Componentsmentioning
confidence: 99%