IgA nephropathy presenting clinicopathological features of acute post-streptococcal glomerulonephritis

Okada, Kaname; Saitoh, Shinichi; Sakaguchi, Zenichi; Zhang, Rui Jin; Kuhara, Takashi; Yasutomo, Koji; Kuroda, Yasuhiro

doi:10.1007/bf02002722

Cited by 9 publications

(8 citation statements)

References 6 publications

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“…Several reports have concerned IgA nephropathy superimposed by PSGN or PIGN [3][4][5][6][7][8][9]. The incidences of IgA nephropathy and PSGN/PIGN are relatively high, but no relationship between their pathogenesis is known.…”

Section: Discussionmentioning

confidence: 96%

Pattern of double glomerulopathy in children

et al. 2007

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Occasional case reports have been issued on children with double glomerulopathy, involving either the coexistence of two different glomerulopathies or superimposition of a second glomerulopathy onto a first. A retrospective clinicopathological review of 294 children who had received renal biopsies resulted in 9 (3.1%) being confirmed to have double glomerulopathy. Superimposed glomerulopathy was diagnosed by a second renal biopsy in two cases, and coexistence of two glomerulopathies was confirmed by single biopsy in seven. Original glomerulopathies were those with a chronic course, such as Alport syndrome, IgA nephropathy, relapsing minimal-change nephrotic syndrome, Frasier syndrome, and thin basement membrane nephropathy. The superimposing glomerulopathies were common types in children, such as postinfectious glomerulonephritis, IgA nephropathy, and Henoch-Schönlein nephritis. Thus, the pattern of double glomerulopathy was considered to be due to the chance occurrence of two different glomerulopathies without a common pathogenesis. Acute nephritic symptoms of superimposed glomerulopathies resolved almost completely during follow-up in most cases. Double glomerulopathies are not rare in children and may occur by chance alone in most cases. The possibility of superimposed glomerulopathy should be suspected if the clinical course of a glomerulopathy changes atypically. However, the long-term influence of a superimposed glomerulopathy on renal functional deterioration remains unclear.

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Section: Discussionmentioning

confidence: 96%

Pattern of double glomerulopathy in children

et al. 2007

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“…The presence of a fibrous crescent in the biopsy specimen suggested that the disease antedated the PSAGN, and the latter could have activated cellular immunity and augmented renal tissue injury [5]. Patients with similar presentation, although rare, have been reported earlier [6,7].…”

Section: Discussionmentioning

confidence: 96%

IgA nephropathy presenting clinical features of poststreptococcal glomerulonephritis

Al-Ruqeishi

Venugopalan

Nour

et al. 2003

Pediatric Nephrology

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IgA nephropathy and poststreptococcal glomerulonephritis are common forms of primary glomerulonephritis in children. This paper reports a 5-year-old Omani boy who had a chance occurrence of these two different glomerular diseases. Our patient presented with clinical features of poststreptococcal glomerulonephritis and then developed recurrent macroscopic hematuria, polyarthritis, bloody diarrhea, and erythematous swelling of the penis. Renal biopsy revealed diffuse mesangial hypercellularity, with focal glomerular sclerosis, fibrous crescents, and mesangial IgA and C3 deposits, consistent with IgA nephropathy. The clinical features and differential diagnosis are outlined.

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“…The presence of S. pyogenes in the biopsy of the control patient with IgA nephropathy may be coincidental. A connection between IgA nephropathy and post-streptococcal glomerulonephritis in some cases is suggested in the literature [34,35 ]. This may also be the case in Hennoch-Schönlein´s purpura, a disease related to IgA nephropathy [36].…”

Section: Discussionmentioning

confidence: 97%

Acute Glomerulonephritis Associated with Streptococcus Pyogenes with Concomitant Spread of Streptococcus Constellatus in Four Rural Families

Almroth¹,

Lindell²,

Åselius³

et al. 2005

Upsala Journal of Medical Sciences

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We studied history, renal histopathology and microbiology of an epidemic of acute glomerulonephritis associated with throat infections and uncommon culture results in four neighbour families.A 40-year-old man (index patient) was referred to a university hospital for dialysis and kidney biopsy due to a suspected acute glomerulonephritis. An acute tonsillitis had preceded the condition. Penicillin treatment had been started four days before the discovery of renal failure. Throat swabs were positive for -hemolytic streptococci, group C (GCS). GCS were also found in throat cultures from his wife and two of their children. The bacteria were typed as Streptococcus constellatus. A third child had S. constellatus expressing Lancefield antigen group G. A neighbour and two of his children fell ill the following week with renal involvement. Throat swabs from both these children were positive for S. constellatus. His third child had erythema multiforme and S. constellatus in the throat while a fourth child hadhemolytic streptococci group A; Streptococcus pyogenes. Kidney biopsies on the index patient and his neighbour showed an acute diffuse prolipherative glomerulonephritis compatible with acute post-streptococcal nephritis and microbiological analysis of renal tissue revealed in both cases S. pyogenes and S. constellatus. The

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IgA nephropathy presenting clinicopathological features of acute post-streptococcal glomerulonephritis

Abstract: These results suggest that in some patients, IgA nephropathy may be triggered by streptococcal infection and misdiagnosed as acute post-streptococcal glomerulonephritis if renal histological examinations are not done.

Cited by 9 publications

References 6 publications

Pattern of double glomerulopathy in children

Pattern of double glomerulopathy in children

IgA nephropathy presenting clinical features of poststreptococcal glomerulonephritis

Acute Glomerulonephritis Associated with Streptococcus Pyogenes with Concomitant Spread of Streptococcus Constellatus in Four Rural Families

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