IgE class immune complexes in Felty's syndrome: characterisation of antibody activities in isolated complexes.

Merétey, K; Falus, András; Bohm, U.; Permin, Henrik; Wiik, Allan

doi:10.1136/ard.43.2.246

Cited by 16 publications

(6 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Histamine release from HuSMC induced by cross-linking of IgE or of IgE receptors. Serum and synovial fluid IgE levels tend to be high in patients with RA (32), and antibodies to IgE and IgE rheumatoid factors have been detected in serum and synovial fluid of RA patients (10,(33)(34)(35)(36). Exposure of isolated HuSMC to anti-IgE (0.1-3 pg/ml)-cross-linking IgE molecules resulted in mast cell activation.…”

Section: Resultsmentioning

confidence: 99%

“…Our results suggest that HuSMC have FcsRI and IgE bound to their surface. Increased IgE levels (32) and IgE-and IgE rheumatoid factor-containing immune complexes have been detected in the serum or synovial fluid of patients with RA (33)(34)(35)(36)58). Anti-IgE autoantibodies have been described in RA, systemic lupus erythematosus, and several other autoimmune diseases (10).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Human synovial mast cells. I. Ultrastructural in situ and in vitro immunologic characterization

Paulis

Marinò

Ciccarelli

et al. 1996

Arthritis & Rheumatism

View full text Add to dashboard Cite

Objective. To examine the ultrastructure of human synovial mast cells in situ, to identify immunologic and nonimmunologic stimuli that activate these cells in vitro, and to quantify a number of preformed and de novo-synthesized mediators.Methods. We conducted an ultrastructural study of synovial mast cells in situ and performed immunoelectron microscopy localization of tryptase and chymase. Isolated synovial mast cells were analyzed biochemically, immunologically, and functionally in vitro and compared with cells from human lung, heart, and skin.Results. Ultrastructural study of synovial tissue revealed mast cells with homogeneously dense, scrolled, crystal, and mixed granules, and lipid bodies in the cytoplasm. A small percentage of mast cells showed evidence of degranulation. Immunoelectron microscopy demonstrated the subcellular localization of tryptase and chymase over granules of >90% of the mast cells, which were of the MC,, subtype. Isolated synovial mast cells released histamine in response to immunologic (anti-IgE and anti-Fcs receptor I [anti-FcsRI]) and nonimmunologic (substance P, recombinant human stem cell factor, and 48/80) stimuli, but did not respond to recombinant human C5a in vitro. Synovial mast cells differed from those isolated from other human tissues, in a variety of immunologic and biochemical features. There was a linear correlation between the percentage of histamine secretion and tryptase release (r = 0.79, P <

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Human synovial mast cells. I. Ultrastructural in situ and in vitro immunologic characterization

Paulis

Marinò

Ciccarelli

et al. 1996

Arthritis & Rheumatism

View full text Add to dashboard Cite

show abstract

“…Results initially reported by Williams et al [1] and data obtained in various laboratories [2][3][4][5][6][7][8][9] have demonstrated that anti-IgE autoantibodies are present in a variety of atopic and inflammatory disorders and occasionally in normal donors [10][11][12][13]. The existence of anti-IgE autoanti bodies in these conditions is starting to be documented, but the real incidence of biologically active anti-IgE au toantibodies in these diseases remains unclear.…”

Section: Introductionmentioning

confidence: 89%

Detection of IgG Subclasses with Anti-lgE Activity in Patients with Atopic Diseases

Carini

Fratazzi²

1992

Int Arch Allergy Immunol

View full text Add to dashboard Cite

Significantly increased levels of IgG anti-IgE were seen in atopic patients as compared with controls. A correlation was observed between the levels of anti-IgE autoantibodies and serum IgE in the groups of atopic patients studied. No significant correlation was found between IgG anti-IgE levels and severity of the disease or between IgG subclasses with anti-IgE activity and clinical status. Analysis of IgG subclasses with anti-IgE activity showed that IgG1 and IgG4 were clearly factors in differentiating the atopies from the controls. IgG2 and IgG3 anti-IgE levels were not statistically significantly elevated. The lack of these autoantibodies may be explained by the presence of immune complexes or the lack of specificity of the monoclonal antibodies used in this study. These observations have not yet determined whether these autoantibodies and the isotypic selection and restriction observed play a role in the dysregulation of the immune response and in the evolution towards atopy.

show abstract

“…[ 51] first reported IgM anti‐IgE in approximately 10% of patients with rheumatoid arthritis in their first description of anti‐IgE autoantibodies. Several studies have confirmed the presence of IgE antiglobulins in the sera or synovial fluid of a significant number of patients with rheumatoid arthritis and rheumatoid vasculitis [ 97–101]. The presence of IgE‐containing immune complexes might interfere with the quantitative determination of IgE levels in patients with rheumatoid arthritis [ 72].…”

Section: Anti‐ige Antibodies In Autoimmune Diseasesmentioning

confidence: 99%

The anti‐IgE/anti‐FcεRIα autoantibody network in allergic and autoimmune diseases

Marone

Spadaro

Palumbo

et al. 1999

Clin Experimental Allergy

View full text Add to dashboard Cite

Basophil granulocytes and tissue mast cells and their mediators play a role in the pathogenesis of several immune and inflammatory disorders. Human basophils and mast cells (FcepsilonRI+ cells) can be activated through immunological interaction with the IgE-FcepsilonRI network. FcepsilonRI+ cells can be triggered by cross-linking between the Fab portions of IgE and multivalent antigens (direct anaphylaxis). 'Reverse type' anaphylaxis can occur through three distinct mechanisms: antibodies against the Fcepsilon portion of IgE (anti-IgE), antibodies against epitopes of the alpha chain of FcepsilonRI (anti-FcepsilonRIalpha) and anti-IgG acting on IgG-IgE complexes bound to FcepsilonRI. Anti-IgE autoantibodies are occasionally present even in normal donors and more frequently in a variety of allergic (chronic urticaria, atopic dermatitis and bronchial asthma) and autoimmune disorders (rheumatoid arthritis, lupus erythematosus and systemic sclerosis). IgG anti-IgE from a small percentage of patients induces the release of mediators from human FcepsilonRI+ cells. Some of the anti-IgE autoantibodies present in allergic patients are non-anaphylactogenic, thus representing a possible protective mechanism preventing the association of IgE with FcepsilonRI. Anti-FcepsilonRIalpha autoantibodies also occur in a significant percentage of patients of chronic urticaria and probably non-allergic asthma and some autoimmune diseases. Although anti-IgE and anti-FcepsilonRIalpha autoantibodies, present in a percentage of patients with immune disorders, are relevant to the pathogenesis of these conditions, much remains to be learnt about their immunochemistry, their prevalence and precise role in various inflammatory diseases.

show abstract

IgE class immune complexes in Felty's syndrome: characterisation of antibody activities in isolated complexes.

Cited by 16 publications

References 18 publications

Human synovial mast cells. I. Ultrastructural in situ and in vitro immunologic characterization

Human synovial mast cells. I. Ultrastructural in situ and in vitro immunologic characterization

Detection of IgG Subclasses with Anti-lgE Activity in Patients with Atopic Diseases

The anti‐IgE/anti‐FcεRIα autoantibody network in allergic and autoimmune diseases

Contact Info

Product

Resources

About