IgE in unselected like-sexed monozygotic and dizygotic twins at birth and at 6 to 9 years of age: High but dissimilar genetic influence on IgE levels

IgE in childhood asthma: relevance of demographic characteristics and polysensitisation

“…However, there is a considerable overlap between sIgE value ranges in healthy and allergic participants 13. In addition, involvement of environmental and also of genetic variables may greatly affect not only allergic disease expression but also IgE synthesis and release 12 23. Indeed, while the development of allergen-specific IgE levels has an absolute requirement for environmental exposure,1 2 23 24 twin studies have shown that the heritability of total IgE levels can be estimated to be approximately 75–85%, with only a small portion of variance attributable to environmental factors 23.…”

Association of IL-5 cytokine production and in vivo IgE levels in infants and parents

“…3 Much effort has been put into unraveling the factors involved in regulating IgE antibody levels. There is clear evidence that total IgE is under a strong genetic influence, 4,5 and epidemiologic studies have demonstrated that IgE levels in human subjects show a strong tracking tendency, even from birth, [6][7][8] although birth levels are not strongly predictive of subsequent allergic disease. 9 It therefore seems that maintaining in vivo homeostasis of IgE levels represents a highly regulated process, the mechanisms of which still remain to be fully elucidated.…”

Primary Prevention of Allergic Diseases: Dreams or Reality?

“…Vitamin D has been shown to in vitro inhibit the rapid increase in the number of T cells and secretion of Th1: IL-2, IFNgamma, and IL-12 cytokines. At the same time, there is evidence that vitamin D supports the development of T-regulatory cells both in vitro and in natural conditions, and this may reduce the likelihood of the development of allergic inflammation [47][48][49].…”