IgE, Reed-Sternberg Cells, and Eosinophilia in Hodgkin's Disease

Samoszuk, Michael; Ramzi, Eiman

doi:10.3109/10428199309148528

Cited by 13 publications

(7 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…despite observations of elevated IgE levels in serum and detectable IgE in HRS cells 49 implies either that there is no association and the excess IgE is produced as a result of the lymphoma, or that the association is modest or relevant only for a subgroup of cases.…”

Section: Discussionmentioning

confidence: 99%

Infectious, autoimmune and allergic diseases and risk of Hodgkin lymphoma in children and adolescents: A Children's Oncology Group study

Linabery

Erhardt

Fonstad

et al. 2014

Intl Journal of Cancer

View full text Add to dashboard Cite

An infectious origin for pediatric Hodgkin lymphoma (HL) has long been suspected and Epstein-Barr virus (EBV) has been implicated in a subset of cases. Increased HL incidence in children with congenital and acquired immunodeficiencies, consistent associations between autoimmune diseases and adult HL, and genome-wide association and other genetic studies together suggest immune dysregulation is involved in lymphomagenesis. Here, healthy control children identified by random digit dialing were matched on sex, race/ethnicity, and age to HL cases diagnosed in 1989-2003 at 0-14 years at Children’s Oncology Group institutions. Parents of 517 cases and 784 controls completed telephone interviews, including items regarding medical histories. Tumor EBV status was determined for 355 cases. Using conditional logistic regression, we calculated odds ratios (ORs) and 95% confidence intervals (CIs) for risk of HL. Cases were more likely to have had an infection >1 year prior to HL diagnosis (OR=1.69, 95% CI:0.98-2.91); case siblings were also more likely to have had a prior infection (OR=2.04, 95% CI:1.01-4.14). Parental history of autoimmunity associated with increased EBV+ HL risk (OR=2.97, 95% CI:1.34-6.58), while having a parent (OR=1.47, 95% CI:1.01-2.14) or sibling (OR=1.62, 95% CI:1.11-2.36) with an allergy was associated with EBV− HL. These results may indicate true increased risk for infections and increased risk with family history of autoimmune and allergic conditions that varies by tumor EBV status, or they may be attributable to inaccurate recall. In addition to employing biomarkers to confirm the role of immune-modulating conditions in pediatric HL, future studies should focus on family-based designs.

show abstract

Section: Discussionmentioning

confidence: 99%

Infectious, autoimmune and allergic diseases and risk of Hodgkin lymphoma in children and adolescents: A Children's Oncology Group study

Linabery

Erhardt

Fonstad

et al. 2014

Intl Journal of Cancer

View full text Add to dashboard Cite

show abstract

“…Eosinophils are also found in many types of human cancers, including both hematological cancers, such as Hodgkin's lymphoma [77], as well as solid tumors [78-83]. Deposition of eosinophilic granular proteins has been found in breast [84], ovarian and uterine tumors [85].…”

Section: Eosinophils and Tumorsmentioning

confidence: 99%

Requirement of macrophages and eosinophils and their cytokines/chemokines for mammary gland development

2002

View full text Add to dashboard Cite

155CSF-1 = colony-stimulating factor 1 or macrophage-colony-stimulating factor; CSF-1R = colony-stimulating-factor-1 receptor; IL = interleukin; MEC = mammary enriched chemokine; MMTV = mouse mammary tumor virus; RANK(-L) = receptor activator of nuclear factor κB (ligand); TEB = terminal end bud; TNF = tumor necrosis factor. Available online http://breast-cancer-research.com/content/4/4/155 IntroductionIt is well established that epithelial/mesenchymal interactions are important for postnatal development of the mammary ductal tree and its differentiation during pregnancy into a milk-producing structure [1]. The mesenchyme contains a heterogeneous group of cells [2] and several of these, such as fat cells and fibroblasts, are capable of producing factors that can promote the growth of epithelial cells [3][4][5][6]. This review focuses on the role of two types of migrant hematopoietic cells, macrophages and eosinophils, that have been recently found to accumulate extensively around terminal end buds (TEBs) during the pubertal burst of ductal growth [7]. Their chemoattractant factors and their roles in mammary cancer are also discussed. Leukocyte homing to the mammary gland AbstractEpithelial/mesenchymal cell interactions are necessary for proper ductal morphogenesis throughout all stages of mammary gland development. Besides the well-established stromal components, such as adipocytes and fibroblasts, the mammary stroma is also infiltrated with migrating blood cells, mostly macrophages and eosinophils. The focus of this review is on the role of macrophages and their growth factor colony-stimulating factor 1 (CSF-1) in promoting branching morphogenesis during postnatal mammary gland development through to lactation. The more restricted role of eosinophils and their chemoattractant eotaxin during pubertal ductal morphogenesis is also discussed. A possible interaction between macrophages and eosinophils in ductal morphogenesis is considered, along with the roles of other chemokines. This role of macrophages in normal development also appears to be subverted by tumors of the mammary gland to promote the escape of the tumor cells from the local environment and enhance their rate of metastasis. These data emphasize the dual role of macrophages in the promotion of epithelial growth in normal and cancer states.

show abstract

“…3,[13][14][15][16][17][18] In this context, eosinophilia has been related to the predominant secretion of T helper cell type 2 (T H 2) eosinophilopoietic or eosinophilotactic cytokines (interleukin [IL] 3, IL-5, and sargramostim) by neoplastic cells. [19][20][21][22][23][24][25][26] Since T H 1 cells are likely to play a key role in the initiation and the persistence of an antitumoral response, while a predominant T H 2 differentiation has been associated with a relative defect of the antitumoral and anti-infectious response, 27 the hypothesis that eosinophilia might be an indicator of poor prognosis was raised.…”

Section: -14mentioning

confidence: 99%