2014
DOI: 10.1002/ijc.28785
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Infectious, autoimmune and allergic diseases and risk of Hodgkin lymphoma in children and adolescents: A Children's Oncology Group study

Abstract: An infectious origin for pediatric Hodgkin lymphoma (HL) has long been suspected and Epstein-Barr virus (EBV) has been implicated in a subset of cases. Increased HL incidence in children with congenital and acquired immunodeficiencies, consistent associations between autoimmune diseases and adult HL, and genome-wide association and other genetic studies together suggest immune dysregulation is involved in lymphomagenesis. Here, healthy control children identified by random digit dialing were matched on sex, ra… Show more

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Cited by 31 publications
(44 citation statements)
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“…Data and specimens were collected in Children's Cancer Group (CCG; now Children's Oncology Group (COG)) Protocol E13: “Case–control study of Hodgkin's Disease in children.”…”
Section: Methodsmentioning
confidence: 99%
See 1 more Smart Citation
“…Data and specimens were collected in Children's Cancer Group (CCG; now Children's Oncology Group (COG)) Protocol E13: “Case–control study of Hodgkin's Disease in children.”…”
Section: Methodsmentioning
confidence: 99%
“…In the United States, HL represents the eighth most common malignancy among children and adolescents <15 years of age and is diagnosed at a rate of 5.6 cases per 1,000,000 person‐years . HL arising in this age group is thought to be an etiologically discrete entity compared with HL in older adolescents and young adults (15–39 years) and older adults (50+ years) because of its distinctive demographic, clinical and pathological characteristics . The few established HL risk factors identified to date include Epstein–Barr virus (EBV) infection, – congenital and acquired immunodeficiency, and family history of HL and other lymphoid neoplasms (LNs; e.g., HL, non‐Hodgkin lymphoma/chronic lymphocytic leukemia, acute lymphoblastic leukemia and multiple myeloma) …”
mentioning
confidence: 99%
“…The presence of aggregated or clustered cases of LH is a known risk factor for this type of tumour. Some authors have proposed infectious aetiologies, such as EBV and herpesvirus (Cader et al, 2010; Linabery et al, 2014). …”
Section: Discussionmentioning
confidence: 99%
“…More suggestive is the higher risk among those who had become parents but not after marriage alone, possibly because the latter does not greatly alter the microbial environment. Others have found prediagnosis infections (other than infectious mononucleosis) to be more prominent among cases (94), and it is tempting to interpret parentage as a measure of exposure to an ubiquitous but unrecognized virus of childhood.…”
Section: Discussionmentioning
confidence: 99%