IGF‐1 and BDNF promote chick bulbospinal neurite outgrowth in vitro

Salie, Rishard; Steeves, John D.

doi:10.1016/j.ijdevneu.2005.07.003

Cited by 32 publications

(27 citation statements)

References 60 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It indicated strongly that the increased endogenous IGF-I expressions in the spared L 6 DRG and the associated spinal dorsal horns were responsible for the sprouting phenomenon. This was supported by previous work which showed that the administration of IGF-I specifically enhanced the extent and rate of axonal outgrowth of the murine corticospinal motor neurons [25], and the axonal outgrowth of injured neurons in the CNS [26]. Also, Ang LC found that IGF-I have neurotrophic activity for motoneurons, an effect possibly mediated by living astrocytes [27].…”

Section: Effects Of Partial Ganglionectomies On Igf-i Expressionssupporting

confidence: 71%

Effects of Electro-Acupuncture on IGF-I Expression in Spared Dorsal Root Ganglia and Associated Spinal Dorsal Horn in Cats Subjected to Adjacent Dorsal Root Ganglionectomies

Dai¹,

Wang

Sun

et al. 2009

Neurochem Res

View full text Add to dashboard Cite

The effects of electro-acupuncture (EA) on insulin-like growth factor-I (IGF-I) expression in the spared dorsal root ganglia (DRG) and associated spinal dorsal horns were explored in cats subjected to unilateral removal of L(1)-L(5) and L(7)-S(2) DRG, sparing the L(6) DRG. Immunohistochemistry revealed the presence of IGF-I immunoreactive products in the L(6) DRG neurons and some neurons and glial cells in the spinal cord. Western blot demonstrated that the level of IGF-I was significantly up-regulated both in the spared DRG and the dorsal horns of L(3) and L(6) cord segments at both 7 and 14 days post operation following EA. The present findings demonstrated the association between neuroplasticity and IGF-I expression, suggesting the possible role of IGF-I in EA promoted spinal cord plasticity.

show abstract

Section: Effects Of Partial Ganglionectomies On Igf-i Expressionssupporting

confidence: 71%

Effects of Electro-Acupuncture on IGF-I Expression in Spared Dorsal Root Ganglia and Associated Spinal Dorsal Horn in Cats Subjected to Adjacent Dorsal Root Ganglionectomies

Dai¹,

Wang

Sun

et al. 2009

Neurochem Res

View full text Add to dashboard Cite

show abstract

“…For example, brain-derived neurotrophic factor (BDNF) and insulin-like growth factor (IGF-1) were shown to be involved in nerve regeneration. 26 Future experiments will examine this issue in the case of hair follicle stem cells.…”

Section: Resultsmentioning

confidence: 99%

Multipotent hair follicle stem cells promote repair of spinal cord injury and recovery of walking function

Amoh

Li²,

Katsuoka³

et al. 2008

Cell Cycle

140

118

View full text Add to dashboard Cite

The mouse hair follicle is an easily accessible source of actively growing, pluripotent adult stem cells. C57BL transgenic mice, labeled with the fluorescent protein GFP, afforded follicle stem cells whose fate could be followed when transferred to recipient animals. These cells appear to be relatively undifferentiated since they are positive for the stem cell markers nestin and CD34 but negative for the keratinocyte marker keratin 15. These hair follicle stem

show abstract

“…BDNF is now also known as a modulator of neurotransmission and synaptic plasticity in the central and peripheral nervous systems (CNS and PNS, respectively) and for its role in neurite growth (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11). In addition to these classical functions, evidence is emerging that BDNF has a broader role in nervous system functionality.…”

mentioning

confidence: 99%

In Vivo Induction of Glial Cell Proliferation and Axonal Outgrowth and Myelination by Brain-Derived Neurotrophic Factor

Groot

Coenen

Verhofstad

et al. 2006

Molecular Endocrinology

View full text Add to dashboard Cite

Brain-derived neurotrophic factor (BDNF) belongs to the neurotrophin family of neuronal cell survival and differentiation factors but is thought to be involved in neuronal cell proliferation and myelination as well. To explore the role of BDNF in vivo, we employed the intermediate pituitary melanotrope cells of the amphibian Xenopus laevis as a model system. These cells mediate background adaptation of the animal by producing high levels of the prohormone proopiomelanocortin (POMC) when the animal is black adapted. We used stable X. transgenesis in combination with the POMC gene promoter to generate transgenic frogs overexpressing BDNF specifically and physiologically inducible in the melanotrope cells. Intriguingly, an approximately 25-fold overexpression of BDNF resulted in hyperplastic glial cells and myelinated axons infiltrating the pituitary, whereby the transgenic melanotrope cells became located dispersed among the induced tissue. The infiltrating glial cells and axons originated from both peripheral and central nervous system sources. The formation of the phenotype started around tadpole stage 50 and was induced by placing white-adapted transgenics on a black background, i.e. after activation of transgene expression. The severity of the phenotype depended on the level of transgene expression, because the intermediate pituitaries from transgenic animals raised on a white background or from transgenics with only an approximately 5-fold BDNF overexpression were essentially not affected. In conclusion, we show in a physiological context that, besides its classical role as neuronal cell survival and differentiation factor, in vivo BDNF can also induce glial cell proliferation as well as axonal outgrowth and myelination.

show abstract

IGF‐1 and BDNF promote chick bulbospinal neurite outgrowth in vitro

Cited by 32 publications

References 60 publications

Effects of Electro-Acupuncture on IGF-I Expression in Spared Dorsal Root Ganglia and Associated Spinal Dorsal Horn in Cats Subjected to Adjacent Dorsal Root Ganglionectomies

Effects of Electro-Acupuncture on IGF-I Expression in Spared Dorsal Root Ganglia and Associated Spinal Dorsal Horn in Cats Subjected to Adjacent Dorsal Root Ganglionectomies

Multipotent hair follicle stem cells promote repair of spinal cord injury and recovery of walking function

In Vivo Induction of Glial Cell Proliferation and Axonal Outgrowth and Myelination by Brain-Derived Neurotrophic Factor

Contact Info

Product

Resources

About