IGF2BP2 Polymorphisms Are Associated with Clinical Characteristics and Development of Oral Cancer

Chou, Chia-Hsuan; Chang, Chien-Yuan; Lu, Hsueh‐Ju; Hsin, Min‐Chien; Chen, Mu‐Kuan; Huang, Hsuan Cheng; Yeh, Chia‐Ming; Lin, Chiao‐Wen; Yang, Shun‐Fa

doi:10.3390/ijms21165662

Cited by 24 publications

(23 citation statements)

References 30 publications

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“…Studies have shown that IGF2BP2 is associated with immune cell infiltration in esophageal cancer [ 18 ]. In addition, a recent study conducted in Taiwan reported that the genetic polymorphism of IGF2BP2 is associated with less favorable clinical features and prognosis of patients with OSCC [ 19 ]. However, there is limited evidence regarding the association between IGF2BP2 and OSCC, and the role of IGF2BP2 in OSCC tumorigenesis has not yet been elucidated.…”

Section: Introductionmentioning

confidence: 99%

IGF2BP2 maybe a novel prognostic biomarker in oral squamous cell carcinoma

Wang

Zhou

et al. 2022

Bioscience Reports

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Aim: The main of this study was to investigate the role of IGF2BP2 in oral squamous cell carcinoma (OSCC) with the overarching of providing new biomarkers or potential therapeutic targets for OSCC. Methods: We combined datasets downloaded from Gene Expression Omnibus (GEO), The Cancer Genome Atlas (TCGA), and samples collected from the clinic to evaluate the expression of IGF2BP2 in OSCC. IGF2BP2 survival analysis was respectively performed based on TCGA, GEO, and clinical samples. Correlations between IGF2BP2 expression and clinicopathological parameters were then analyzed, and signaling pathways associated with IGF2BP2 expression were identified using gene set enrichment analysis (GSEA 4.1.0). Moreover, an IGF2BP2 co-expressed gene network was constructed, followed by gene ontology (GO) functional enrichment analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis on IGF2BP2 co-expressed genes. Finally, TIMER and CIBERSORT were used to analyze the correlations among IGF2BP2, IGF2BP2-coexpressed genes, and tumor-infiltrating immune cells (TICs). Results: IGF2BP2 was highly expressed in OSCC and significantly correlated with overall survival of OSCC patients (p＜0.01). High IGF2BP2 expression correlated with poor overall survival. The GSEA results showed that cell apoptosis-, tumor-, and immune-related pathways were significantly enriched in samples with high IGF2BP2 expression. Furthermore, GO and KEGG enrichment analysis results of IGF2BP2 co-expressed genes indicated that these genes are mainly associated with immunity/inflammation and tumorigenesis. In addition, IGF2BP2 and its co-expressed genes are associated with tumor-infiltrating immune cells (p<0.01). Conclusion: IGF2BP2 may be a potential prognostic biomarker in OSCC and correlates with immune infiltrates.

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Section: Introductionmentioning

confidence: 99%

IGF2BP2 maybe a novel prognostic biomarker in oral squamous cell carcinoma

Wang

Zhou

et al. 2022

Bioscience Reports

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“…The expression of IGF2BP2 is significantly upregulated in head and neck squamous cell carcinoma (HNSC) tissue and predicts a poor prognosis ( 12 ). In addition, IGF2BP2 polymorphisms are associated with adverse clinical features and the development of oral cancers ( 13 ).…”

Section: Introductionmentioning

confidence: 99%

Upregulation of IGF2BP2 Promotes Oral Squamous Cell Carcinoma Progression That Is Related to Cell Proliferation, Metastasis and Tumor-Infiltrating Immune Cells

Zhou

Cai

et al. 2022

Front. Oncol.

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The strong invasive and metastatic abilities of oral squamous cell carcinoma (OSCC) cells in the early stage are the main reason for its poor prognosis. The early diagnosis and treatment of OSCC may reduce the metastasis rate and improve the survival rate. The aim of this study was to explore candidate biomarkers related to the prognosis and progression of OSCC. We performed weighted gene coexpression network analysis to identify key modules and genes associated with OSCC and intersected the differentially expressed genes (DEGs) in The Cancer Genome Atlas (TCGA)-OSCC and GSE30784 datasets. Next, we performed survival analysis and immunohistochemistry to screen and validate the hub gene insulin-like growth factor 2 (IGF2) mRNA binding protein 2 IGF2BP2. We also used TCGA pan-cancer data to verify that IGF2BP2 was expressed at high levels in a variety of cancers and was related to a poor prognosis in patients. Furthermore, we divided patients with OSCC into high and low expression groups based on the median expression level of IGF2BP2. Gene set enrichment analysis (GSEA) showed that IGF2BP2 led to a poor prognosis in OSCC by affecting cancer-related (epithelial-mesenchymal transition, glycolysis, cell cycle, etc.) and immune-related biological functions and pathways. Single-sample GSEA (ssGSEA), CIBERSORT, and xCell algorithms helped reveal that high IGF2BP2 expression was accompanied by a significant reduction in the immune score, stromal score, and microenvironment score and a decrease in the number of infiltrating CD8+ T cells in OSCC. In addition, silencing IGF2BP2 suppressed the proliferation, migration, and invasion of OSCC cells. In general, IGF2BP2 is a potential biomarker for the progression, immunotherapy response, and prognosis of OSCC.

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“…The pro-inflammatory cytokine interleukin 8 and related SNP is associated with the susceptibility of oral squamous cell carcinoma [ 36 ]. In addition, the higher Insulin-like growth factor 2 mRNA-binding protein 2 was found in head and neck squamous cell carcinoma and correlated with higher cancer stage and larger tumor size [ 17 ], while the presence of ADAMTS14 SNP rs12774070 was significantly associated with the degree of oral tumor cell differentiation [ 37 ]. In addition, gene-environment interactions exist in oral cancer; CD44 polymorphisms and betel quid chewing or tobacco smoking enhance the susceptibility to oral cancer occurrence [ 38 ].…”

Section: Discussionmentioning

confidence: 99%

“…Similar to other types of cancers, the environment as well as genetic factors will influence the clinical presentation and disease severity of oral cancer [ 12 , 13 , 14 , 15 , 16 ]. For instance, the insulin-like growth factor 2 mRNA-binding protein 2, a protein that contributes to insulin resistance and lipid metabolism, was related to less favorable clinical characters for oral cancer [ 17 ]. Additionally, the genetic polymorphism of chemokine receptor-2 gene enhances the susceptibility of oral cancer development [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

Genetic Variants of lncRNA GAS5 Are Associated with the Clinicopathologic Development of Oral Cancer

Hsieh

Lin

et al. 2021

JPM

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The long noncoding RNA, Growth arrest-specific 5 (GAS5) plays a crucial role in the development of oral cancer. However, potential genetic variants in GAS5 that affect the susceptibility and progression of oral cancer have rarely been explored. In this study, two loci of GAS5 single nucleotide polymorphisms (SNPs) (rs145204276 and rs55829688) were genotyped by using the TaqMan allelic discrimination in 1125 oral cancer patients and 1195 non-oral-cancer individuals. After statistical analyses, the distribution of both the GAS5 SNP rs145204276 and GAS5 SNP rs55829688 frequencies were similar between the study and control groups. However, the patients with GAS5 SNP rs145204276 variants (Ins/Del or Del/Del) showed a higher tendency of moderate to poor cell differentiation of oral cancer (OR: 1.454, 95% CI: 1.041–2.031, p = 0.028). Moreover, the GAS5 SNP rs145204276 variants (Ins/Del or Del/Del) in the non-alcohol-drinking population were associated with significantly advanced tumor stage (OR: 1.500, 95% CI: 1.081–2.081, p = 0.015) and larger tumor size (OR: 1.494, 95% CI: 1.076–2.074, p = 0.016). Furthermore, individuals with the GAS5 SNP rs145204276 variant were associated with a higher expression of GAS5 in the GTEx database (p = 0.002), and the higher GAS5 level was associated with poor cell differentiation, advanced tumor stage and larger tumor size in head and neck squamous cell carcinoma from the TCGA database (all p < 0.05). In conclusion, the GAS5 SNP rs145204276 variant is related to poor-differentiation cell status in oral cancer. Besides, the presence of the GAS5 SNP rs145204276 variant is associated with a worse tumor stage and tumor size in oral cancer patients without alcohol drinking.

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IGF2BP2 Polymorphisms Are Associated with Clinical Characteristics and Development of Oral Cancer

Cited by 24 publications

References 30 publications

IGF2BP2 maybe a novel prognostic biomarker in oral squamous cell carcinoma

IGF2BP2 maybe a novel prognostic biomarker in oral squamous cell carcinoma

Upregulation of IGF2BP2 Promotes Oral Squamous Cell Carcinoma Progression That Is Related to Cell Proliferation, Metastasis and Tumor-Infiltrating Immune Cells

Genetic Variants of lncRNA GAS5 Are Associated with the Clinicopathologic Development of Oral Cancer

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