IGF2BP3-EGFR-AKT axis promotes breast cancer MDA-MB-231 cell growth

Jing, Xinli; Han, Cong; Li, Qian; Li, Fang; Zhang, Jinyuan; Jiang, Qingwei; Zhao, Fang; Guo, Chen; Chen, Jinfeng; Jiang, Ting; Wang, Xiaofei; Chen, Yanke; Huang, Chen

doi:10.1016/j.bbamcr.2023.119542

Cited by 1 publication

(1 citation statement)

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“…In this review, we present recent progress in the exploration of natural products as potent anticancer agents, focusing on the effect of a well-known polyphenol, Rosmarinic Acid, on MDA-MB-231 and MDA-MB-468 cells. These cells constitute TNBC, an aggressive and metastatic subtype unaffected by hormone therapy [ 33 ]. We present a range of integrated chemical biology techniques aimed at using relevant mechanisms of action that might lead to major therapeutic advancements in the treatment of BC [ 3 , 4 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 ].…”

Section: Introductionmentioning

confidence: 99%

Molecular Pathways of Rosmarinic Acid Anticancer Activity in Triple-Negative Breast Cancer Cells: A Literature Review

Konstantinou,

Panagiotopoulos,

Argyri

et al. 2023

Nutrients

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Breast cancer is the most frequent type of cancer in women. Oncogenic transcription factors promote the overproduction of cellular adhesion molecules and inflammatory cytokines during cancer development. Cancer cells exhibit significant upregulation of antiapoptotic proteins, resulting in increased cell survival, tumor growth, and metastasis. Research on the cell cycle-mediated apoptosis pathway for drug discovery and therapy has shown promising results. In fact, dietary phytoconstituents have been extensively researched for anticancer activity, providing indirect protection by activating endogenous defense systems. The role of polyphenols in key cancer signaling pathways could shed light on the underlying mechanisms of action. For instance, Rosmarinic Acid, a polyphenol constituent of many culinary herbs, has shown potent chemoprotective properties. In this review, we present recent progress in the investigation of natural products as potent anticancer agents, with a focus on the effect of Rosmarinic Acid on triple-negative BC cell lines resistant to hormone therapy. We highlight a variety of integrated chemical biology approaches aimed at utilizing relevant mechanisms of action that could lead to significant clinical advances in BC treatment.

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