IgG anti-toxoplasma antibodies among asymptomatic HIV-infected patients in Marrakesh-Morocco

Addebbous, Amal; Adarmouch, Latifa; Tali, Abdelali; Laboudi, Majda; Amine, Mohamed; Aajly, Lahcen; Roubal, M.; Chabaâ, L.; Zougaghi, L.

doi:10.1016/j.actatropica.2012.02.070

Cited by 19 publications

(12 citation statements)

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“…The high prevalence of T.gondii in HIV positive individuals suggests the risk of cerebral toxoplasmosis in patients that do not have access to HIV treatment. Cerebral toxoplasmosis is one of the sequels of T.gondii in HIV patients [ 69 – 71 ], and in the absence of chemo-prophylaxis against HIV, up to 40 % of patients co-infected with T. gondii may develop fatal Toxoplasma encephalitis [ 6 ]. Before the start of the highly active anti-reteroviral therapy (HAART) in Ethiopia, neural toxoplasmosis was one of the complications [ 72 ] with mortality in more than a third of the patients [ 72 , 73 ], and after the initiation of HAART, immune reconstitution inflammatory syndrome (IRIS) was one of the sequels of toxoplasmosis [ 74 – 76 ].…”

Section: Discussionmentioning

confidence: 99%

A meta-analysis of the prevalence of Toxoplasma gondii in animals and humans in Ethiopia

Gebremedhin

Tadesse

2015

Parasites Vectors

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BackgroundToxoplasmosis is a worldwide zoonosis. The objectives of this study were to estimate the prevalence and assess the potential risk factors of Toxoplasma gondii infections in animals and humans in Ethiopia by using meta-analytical methods.MethodsPublished studies on T. gondii in animals and humans in Ethiopia were searched in Medline, Google Scholar and the lists of references of articles. Eligible studies were selected by using inclusion and exclusion criteria. The risks of within and across study biases, and the variations in prevalence estimates attributable to heterogeneities were assessed. Pooled prevalence was estimated by the DerSimonian and Laird random effects model.ResultsThirty two studies were eligible and data from 5689 animals and 5718 humans were used for quantitative syntheses. The pooled IgG seroprevalence in cats, small ruminants and humans were estimated at 87.72 % (95 % CI = 78.63, 93.28), 34.59 % (95 % CI = 21.08, 51.12) and 74.73 % (95 % CI = 61.85, 84.36), respectively. The odds of infections were higher in pregnant than in non pregnant women (OR = 3.96), in individuals that had contact with cats than those with no contact (OR = 2.53), and in urban than in rural inhabitants (OR = 2.06).ConclusionsToxoplasmosis is highly prevalent and could be a cause of considerable reproductive wastage in small ruminants and multiple diseases in humans in Ethiopia. Public education on preventive measures could help reduce the transmission of the parasite to humans.Electronic supplementary materialThe online version of this article (doi:10.1186/s13071-015-0901-7) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

A meta-analysis of the prevalence of Toxoplasma gondii in animals and humans in Ethiopia

Gebremedhin

Tadesse

2015

Parasites Vectors

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“…In one study conducted in Rabat and concerning pregnant women, school level and knowledge of toxoplasmosis modes transmission were found to be risk factors (p < 0.01), while the consumption of raw meat, contact with cats, and level of hygiene were not significant. Toxoplasmosis was also studied in HIV-infected patients in the city of Marrakech and its surroundings [1]. The authors studied the seroprevalence of T. gondii in 95 HIV-infected adults of different ages.…”

Section: Toxoplasma Gondii Infection In Moroccomentioning

confidence: 99%

Toxoplasma gondii infection and toxoplasmosis in North Africa: a review

Rouatbi¹,

Amairia²,

Amdouni³

et al. 2019

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Toxoplasmosis is an important zoonosis caused by an obligate intracellular parasitic protozoan, Toxoplasma gondii. The disease is distributed worldwide and can affect all warm-blooded vertebrates, including humans. The present review aimed to collect, compile and summarize the data on the prevalence of T. gondii infection in humans and animals in the five North African countries (Morocco, Algeria, Tunisia, Libya and Egypt). Published data from national and international databases were used. Distribution patterns and risk factors for T. gondii infection are discussed, focusing on biotic and abiotic factors. This review is a comprehensive epidemiological analysis of T. gondii infection in North Africa and will therefore be a useful tool for researchers. It can also be used to propose or enhance appropriate national toxoplasmosis control programs.

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“…The seroprevalence of toxoplasmosis is high in immunocompromised patients, such as those infected with human immunodeficiency virus (HIV), and transplant or cancer patients treated with immunosuppressive agents [5], [97], [98].…”

Section: Introductionmentioning

confidence: 99%

“…A newborn exposed to T. gondii in utero may develop congenital toxoplasmosis with major ocular and neurological consequences. In immunosuppressed (HIV, organ transplant or cancer) patients, the infection can lead to life-threatening cerebral toxoplasmosis [97], [98], [152].…”

Section: Introductionmentioning

confidence: 99%

Toxoplasmosis – A Global Threat. Correlation of Latent Toxoplasmosis with Specific Disease Burden in a Set of 88 Countries

et al. 2014

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BackgroundToxoplasmosis is becoming a global health hazard as it infects 30–50% of the world human population. Clinically, the life-long presence of the parasite in tissues of a majority of infected individuals is usually considered asymptomatic. However, a number of studies show that this ‘asymptomatic infection’ may also lead to development of other human pathologies.Aims of the StudyThe purpose of the study was to collect available geoepidemiological data on seroprevalence of toxoplasmosis and search for its relationship with mortality and disability rates in different countries.Methods and FindingsPrevalence data published between 1995–2008 for women in child-bearing age were collected for 88 countries (29 European). The association between prevalence of toxoplasmosis and specific disease burden estimated with age-standardized Disability Adjusted Life Year (DALY) or with mortality, was calculated using General Linear Method with Gross Domestic Product per capita (GDP), geolatitude and humidity as covariates, and also using nonparametric partial Kendall correlation test with GDP as a covariate. The prevalence of toxoplasmosis correlated with specific disease burden in particular countries explaining 23% of variability in disease burden in Europe. The analyses revealed that for example, DALY of 23 of 128 analyzed diseases and disease categories on the WHO list showed correlations (18 positive, 5 negative) with prevalence of toxoplasmosis and another 12 diseases showed positive trends (p<0.1). For several obtained significant correlations between the seroprevalence of toxoplasmosis and specific diseases/clinical entities, possible pathophysiological, biochemical and molecular explanations are presented.ConclusionsThe seroprevalence of toxoplasmosis correlated with various disease burden. Statistical associations does not necessarily mean causality. The precautionary principle suggests however that possible role of toxoplasmosis as a triggering factor responsible for development of several clinical entities deserves much more attention and financial support both in everyday medical practice and future clinical research.

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IgG anti-toxoplasma antibodies among asymptomatic HIV-infected patients in Marrakesh-Morocco

Cited by 19 publications

References 14 publications

A meta-analysis of the prevalence of Toxoplasma gondii in animals and humans in Ethiopia

A meta-analysis of the prevalence of Toxoplasma gondii in animals and humans in Ethiopia

Toxoplasma gondii infection and toxoplasmosis in North Africa: a review

Toxoplasmosis – A Global Threat. Correlation of Latent Toxoplasmosis with Specific Disease Burden in a Set of 88 Countries

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