IgG subclass distribution of antibodies to bacterial and viral antigens

Fèrrante, Antonio; Beard, Lorraine J.; Feldman, Robert G.

doi:10.1097/00006454-199008001-00004

Cited by 155 publications

(143 citation statements)

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“…and children the IgG anti-polysaccharide antibodies predominantly reside in the IgGl subclass (4,5). The mechanisms that determine the localization of anti-polysaccharide antibodies in the IgG2 subclass are poorly understood.…”

mentioning

confidence: 99%

Immunoglobulin Isotype-Specific Antibody Responses to Pneumococcal Polysaccharide Vaccine in Patients with Recurrent Bacterial Respiratory Tract Infections

et al. 1995

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mentioning

confidence: 99%

Immunoglobulin Isotype-Specific Antibody Responses to Pneumococcal Polysaccharide Vaccine in Patients with Recurrent Bacterial Respiratory Tract Infections

et al. 1995

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“…The use of NPcarrier Ag to mimic a coinfection response during malaria has the advantages of a lack of competition for resources between the infecting agents, greater reproducibility between experiments, and the ability to use widely available reagents to monitor the immune response to the NP-hapten. The prototypical response to soluble protein or carbohydrate Ags are of the IgG1 or IgG3 subclasses in mouse models (25). The predominant Ab isotype made during immune responses to the model Ag NP-OVA is of the IgG1 subclass (26).…”

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confidence: 99%

Acute Plasmodium chabaudi Infection Dampens Humoral Responses to a Secondary T-Dependent Antigen but Enhances Responses to a Secondary T-Independent Antigen

Wilmore

Maue

Lefebvre

et al. 2013

The Journal of Immunology

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High rates of coinfection occur in malaria endemic regions, leading to more severe disease outcomes. Understanding how coinfecting pathogens influence the immune system is important in the development of treatment strategies that reduce morbidity and mortality. Using the Plasmodium chabaudi mouse model of malaria and immunization with model Ags that are either T-dependent (4-hydroxy-3-nitrophenyl [NP]-OVA) or T-independent (NP-Ficoll), we analyzed the effects of acute malaria on the development of humoral immunity to secondary Ags. Total Ig and IgG1 NP–specific Ab responses to NP-OVA were significantly decreased in the P. chabaudi–infected group compared with the uninfected group, whereas NP-specific IgG2c Ab was significantly increased in the P. chabaudi–infected group. In contrast, following injection with T-independent NP-Ficoll, the P. chabaudi–infected group had significantly increased NP-specific total Ig, IgM, and IgG2c Ab titers compared with controls. Treatment with anti–IFN-γ led to an abrogation of the NP-specific IgG2c Ab induced by P. chabaudi infection but did not affect other NP-specific Ab isotypes or titers. IFN-γ depletion also increased the percentage of plasma cells in both P. chabaudi–infected and uninfected groups but decreased the percentage of B cells with a germinal center (GC) phenotype. Using immunofluorescent microscopy, we were able to detect NP+ GCs in the spleens of noninfected mice, but there were no detectible NP+ GCs in mice infected with P. chabaudi. These data suggest that during P. chabaudi infection, there is a shift toward an extrafollicular Ab response that could be responsible for decreased Ab responses to secondary T-dependent Ags.

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“…As subclasses de IgG estão envolvidas na opsonização, fixação de complemento e fixação à macrófagos (BUCKLEY, 1998;SAELAND et al, 2003 (BUCKLEY, 1998;FERRANTE et al, 1990;PASTORINO;JACOB;GRUMACH, 1994;SAELAND et al, 2003 Durante o processo infeccioso ou após a imunização, a persistência e o pico das concentrações de IgG variam, ou seja, o estímulo antigênico acarreta uma resposta imunológica com a produção de todas as subclasses de IgG, porém ocorrem aumentos significativos em apenas uma ou duas subclasses. As conseqüências desta restrição na produção das subclasses de IgG e a diferença funcional entre elas apresentam um papel importante na defesa do hospedeiro, assim como no processo imunopatogênico da doença (FERRANTE et al, 1990;PASTORINO;JACOB;GRUMACH, 1994).…”

Section: Isotipagem De Anticorpos Anti-ps14 E Anti-rpspa3unclassified

“…As conseqüências desta restrição na produção das subclasses de IgG e a diferença funcional entre elas apresentam um papel importante na defesa do hospedeiro, assim como no processo imunopatogênico da doença (FERRANTE et al, 1990;PASTORINO;JACOB;GRUMACH, 1994).…”

Section: Isotipagem De Anticorpos Anti-ps14 E Anti-rpspa3unclassified

“…As subclasses IgG1 e IgG3 humanas são as predominantes na resposta determinada por antígenos protéicos, enquanto a subclasse IgG2 humana predomina na resposta contra antígenos polissacarídicos (ver Tabelas 3 e 4) (ALONSO DE VELASCO et al, 1995b;BUCKLEY, 1998;FERRANTE et al, 1990;PASTORINO;JACOB;GRUMACH, 1994;GONZÁLEZ-FERNÁNDEZ;FARO;FERNÁNDEZ, 2008 …”

Section: Isotipagem De Anticorpos Anti-ps14 E Anti-rpspa3unclassified

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Desenvolvimento e avaliação da resposta imune humoral de uma vacina anti-pneumocócica conjugada: polissacarídeo capsular sorotipo 14 - proteína de superfície pneumocócica A.

Santamaria¹

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IgG subclass distribution of antibodies to bacterial and viral antigens

Cited by 155 publications

References 0 publications

Immunoglobulin Isotype-Specific Antibody Responses to Pneumococcal Polysaccharide Vaccine in Patients with Recurrent Bacterial Respiratory Tract Infections

Immunoglobulin Isotype-Specific Antibody Responses to Pneumococcal Polysaccharide Vaccine in Patients with Recurrent Bacterial Respiratory Tract Infections

Acute Plasmodium chabaudi Infection Dampens Humoral Responses to a Secondary T-Dependent Antigen but Enhances Responses to a Secondary T-Independent Antigen

Desenvolvimento e avaliação da resposta imune humoral de uma vacina anti-pneumocócica conjugada: polissacarídeo capsular sorotipo 14 - proteína de superfície pneumocócica A.

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