IgG1 deficiency and high IgA level with juvenile idiopathic arthritis

Yıldız, Bilal; Kural, Nurdan

doi:10.1007/s00431-006-0360-4

Cited by 5 publications

(6 citation statements)

References 2 publications

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“…High IgA levels have been reported in a patient with JIA. 56 Gilliam et al 57 have shown that JIA patients with joint erosions and joint-space narrowing had significantly elevated levels of IgA. The etiology of JIA is unclear, but because of similarity in genetic influences on IgA and JIA, it is possible that these traits share a common pathophysiological pathway and our findings support further investigation of the involvement of IgA in JIA etiology.…”

Section: Clusters Of Phenotypes Defined By Pleiotropic Linkssupporting

confidence: 78%

Abundant Pleiotropy in Human Complex Diseases and Traits

Sivakumaran

Agakov

Τheodoratou

et al. 2011

The American Journal of Human Genetics

505

418

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We present a systematic review of pleiotropy among SNPs and genes reported to show genome-wide association with common complex diseases and traits. We find abundant evidence of pleiotropy; 233 (16.9%) genes and 77 (4.6%) SNPs show pleiotropic effects. SNP pleiotropic status was associated with gene location (p = 0.024; pleiotropic SNPs more often exonic [14.5% versus 4.9% for nonpleiotropic, trait-associated SNPs] and less often intergenic [15.8% versus 23.6%]), "predicted transcript consequence" (p = 0.001; pleiotropic SNPs more often predicted to be structurally deleterious [5% versus 0.4%] but not more often in regulatory sequences), and certain disease classes. We develop a method to calculate the likelihood that pleiotropic links between traits occurred more often than expected and demonstrate that this approach can identify etiological links that are already known (such as between fetal hemoglobin and malaria risk) and those that are not yet established (e.g., between plasma campesterol levels and gallstones risk; and between immunoglobulin A and juvenile idiopathic arthritis). Examples of pleiotropy will accumulate over time, but it is already clear that pleiotropy is a common property of genes and SNPs associated with disease traits, and this will have implications for identification of molecular targets for drug development, future genetic risk-profiling, and classification of diseases.

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Section: Clusters Of Phenotypes Defined By Pleiotropic Linkssupporting

confidence: 78%

Abundant Pleiotropy in Human Complex Diseases and Traits

Sivakumaran

Agakov

Τheodoratou

et al. 2011

The American Journal of Human Genetics

505

418

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“…We have previously shown a dichotomous association between IgA and IgG1 responses directed against adult worm antigens in a different Zimbabwean population (13), and the spot identification in Figure 3a shows that there are some antigens recognized either by IgG1 or by IgA but not by both antibodies. An inverse relationship has also been reported in a case of idiopathic arthritis where patients deficient in IgG1 had high titres of IgA (37), suggesting that the expression of these two subclasses is differentially regulated. IgG1 recognized the largest number of antigenic spots: 45 including 8 of the 10 of the WHO’s schistosome vaccine candidates.…”

Section: Discussionmentioning

confidence: 77%

Differential recognition patterns of Schistosoma haematobium adult worm antigens by the human antibodies IgA, IgE, IgG1 and IgG4

Mutapi

Bourke

Harcus

et al. 2011

Parasite Immunology

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Schistosoma haematobium antigen recognition profiles of the human isotypes IgA, IgE, IgG1 and IgG4 were compared by image analysis of western blots. Adult worm antigens separated by two-dimensional gel electrophoresis were probed with pooled sera from Zimbabweans resident in a S. haematobium endemic area, followed by the identification of individual antigenic parasite proteins using mass spectrometry. Overall, IgG1 reacted with the largest number of antigens, followed by IgE and IgA which detected the same number, while IgG4 detected the fewest antigens. IgE recognized all antigens reactive with IgG4 as well as an additional four antigens, an isoform of 28-kDa GST, phosphoglycerate kinase, actin 1 and calreticulin. IgG1 additionally recognized fatty acid–binding protein, triose-phosphate isomerase and heat shock protein 70, which were not recognized by IgA. Recognition patterns varied between some isoforms, e.g. the two fructose 1-6-bis-phosphate aldolase isoforms were differentially recognized by IgA and IgG1. Although the majority of S. haematobium adult worm antigens are recognized by all of the four isotypes, there are clear restrictions in antibody recognition for some antigens. This may partly explain differences observed in isotype dynamics at a population level. Differential recognition patterns for some isoforms indicated in the study have potential importance for vaccine development.

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“…Serum immunoglobulin A was elevated in our patient at double the normal level and normalized in the follow-up. Another case was reported in Yildiz B & Kural N et al where the elevation of immunoglobulin A remained the same (12) . Therefore our finding is much more significant and is probably linked to the controlling of diet and possible allergens since symptomatic or anti-inflammatory medication, as we know, can only be withdrawn when the disease has been controlled.…”

Section: Discussionmentioning

confidence: 81%

“…Immunological markers are also affected in JIA cases such as the increase in serum immunoglobulin A (12) . These changes are also part of the non-IgE mediated manifestations in relation to food hypersensitivity (10,13,14) .…”

Section: Discussionmentioning

confidence: 99%

Juvenile “idiopathic” arthritis (JIA) as a manifestation of food allergy. Case Study

Muñoz-Urribarri

Godos

Durand

et al. 2020

Rev Gastroenterol Peru

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Studies linking type of diet and juvenile idiopathic arthritis (JIA) have variable results and are inconsistent. This case shows an evolution which fulfilled the criteria of JIA, but was diagnosed as food allergy. Case: A seven-year old boy had fever, arthralgia, general malaise, headaches, abdominal pain and rashes. These symptoms were diagnosed as fever of unknown origin (FUO) and probable JIA. There was a stabbing pain in the right iliac fossa. An upper and lower endoscopy were performed and nodular ileocolitis was detected. A hypoallergenic diet was prescribed, in addition to mesalazine and oral corticosteroids. The patient was asymptomatic for 2.5 months and then relapsed with all symptoms after consuming dairy. This JIA case shows the diagnostic phases of food allergy: improvement and recurrence of symptoms with the reintroduction of the allergen (oral challenge=gold standard of food allergy). There is evidence that supports the existence of a gut-joint axis, where the luminal content triggers a series of immunologically mediated reactions that can cause systemic diseases such as J other connective tissue diseases. This case report adds reasonable evidence in support of food allergy as a cause of JIA.

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IgG1 deficiency and high IgA level with juvenile idiopathic arthritis

Cited by 5 publications

References 2 publications

Abundant Pleiotropy in Human Complex Diseases and Traits

Abundant Pleiotropy in Human Complex Diseases and Traits

Differential recognition patterns of Schistosoma haematobium adult worm antigens by the human antibodies IgA, IgE, IgG1 and IgG4

Juvenile “idiopathic” arthritis (JIA) as a manifestation of food allergy. Case Study

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