IgG4‐positive extranodal marginal zone lymphoma arising in Hashimoto's thyroiditis: clinicopathological and cytogenetic features of a hitherto undescribed condition

Tan, Char Loo; Ong, Yew Kwang; Tan, Soo Yong; Ng, Siok Bian

doi:10.1111/his.12854

Cited by 13 publications

(6 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…100 Hashimoto thyroiditis is now classified into IgG4 and non-IgG4 types, 101 and an IgG4+ thyroid MALT lymphoma was reported recently. 102,103 In thyroid MALT lymphoma, tumour cells tend to invade and expand thyroid follicles, forming lymphoepithelial lesions or occupying their lumina. Some cases may transform to DLBCL.…”

Section: Thyroid Glandmentioning

confidence: 99%

Marginal zone B-cell lymphoma: lessons from Western and Eastern diagnostic approaches

Nakamura

Ponzoni

2020

Pathology

View full text Add to dashboard Cite

Section: Thyroid Glandmentioning

confidence: 99%

Marginal zone B-cell lymphoma: lessons from Western and Eastern diagnostic approaches

Nakamura

Ponzoni

2020

Pathology

View full text Add to dashboard Cite

“…In an in situ hybridization study, the lesion was finally diagnosed as MALToma. Similarly, two other cases were reported of thyroid lymphoma with IgG4-positive plasma cell infiltration combined with HT ( 21 , 22 ). Therefore, discrimination of IgG4 HT and PTL is important due to the different treatment strategies and prognoses for these two diseases.…”

Section: Discussionmentioning

confidence: 64%

Clinical differences between IgG4 Hashimoto’s thyroiditis and primary thyroid lymphoma

Liu

Chen

et al. 2022

European Thyroid Journal

View full text Add to dashboard Cite

Background: Hashimoto’s thyroiditis (HT) can be divided into IgG4 HT and non-IgG4 HT based on IgG4 and IgG immunohistochemical staining. In clinical practice, it is often necessary to identify diseases such as primary thyroid lymphoma (PTL) and IgG4 HT when a patient presents with a rapidly enlarged thyroid. The aim of our study was to uncover the differential points between the two diseases. Methods: Clinical information from 19 IgG4 HT and 10 PTL patients was obtained from the patients’ medical records, including age, sex, main clinical manifestation, thyroid functional status, the presence of serum anti-thyroid peroxidase antibodies, anti-thyroglobulin antibodies and thyroid ultrasonography results. Thyroid sections from all patients were collected to detect IgG4 and IgG expression by immunohistochemical staining. Results: The IgG4 HT patients were significantly younger than those in PTL group (39.68±10.95 vs. 66.20±10.23 years, P < 0.001). There were no significant differences in the sex distribution or TgAb- or TPOAb-positive rates. The PTL group had a higher prevalence of clinical hypothyroidism than that of the IgG4 HT group (P=0.016). In PTL group, thyroid lesions were more likely to exhibit hypoechogenicity (6/6 vs. 1/19, P<0.001) on ultrasound images. In PTL group, 2 patients met the immunohistochemical cut-off value of the criteria for IgG4 HT. Conclusions: Simply relying on immunohistochemistry for IgG4 cannot diagnose IgG4 HT correctly when a patient presents with rapid thyroid enlargement. A combination of clinical, pathological analyses helps distinguish IgG4 HT from PTL which may be with abundant IgG4-positive plasma cells.

show abstract

“…Table 2 presents the baseline demographics, clinical findings, and outcomes of IgG4‐positive MZL from the individual cases ( n = 24) 12,13,23–36 . Table 3 shows detailed data of each case.…”

Section: Resultsmentioning

confidence: 99%

“…Table 2 presents the baseline demographics, clinical findings, and outcomes of IgG4-positive MZL from the individual cases (n = 24). 12,13,[23][24][25][26][27][28][29][30][31][32][33][34][35][36] Table 3 shows detailed data of each case. Existing cases of IgG4-positive MZLs were predominantly male (83.3%).…”

Section: Description Of Included Studiesmentioning

confidence: 99%

Clinical characteristics and outcomes of IgG4‐positive marginal zone lymphoma: Systematic scoping review

Nishimura

Wien

Nishimura

et al. 2022

Pathology International

View full text Add to dashboard Cite

Immunoglobulin G4 (IgG4)‐positive marginal zone lymphoma (MZL) is rare and undefined. It is unclear whether IgG4‐positive MZLs have as favorable an outcome as MZLs in general. Also, correlation with IgG4‐related disease (IgG4‐RD) and IgG4‐positive MZLs is unknown. Following the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses extension for scoping reviews, we searched MEDLINE and EMBASE for all peer‐reviewed articles using keywords including“IgG4” and “marginal zone lymphoma” from their inception to February 20, 2022. Twenty‐two articles, including six observational studies and 24 cases from 16 case reports and case series, were included. Only one study had a comparative group, and the other five were exploratory observational studies. IgG4‐positive MZLs commonly occurred in males (83.3%). It primarily involved ocular adnexa (41.7%) and skin (29.2%). Only 29.2% had concurrent IgG4‐RD, and no expiration was noted. While most cases were treated with excision, resection, or clinical observation, 21.7% received rituximab‐cyclophosphamide, doxorubicin, vincristine, and prednisone as a first‐line treatment. This systematic review summarizes the current understanding of the characteristics of IgG4‐positive MZLs. While there seems to be IgG4‐RD‐related and de novo IgG4‐positive MZLs, future research needs to clearly define MZL with polyclonal IgG4‐positive cells and IgG4‐producing lymphoma. Further studies are critical to clarifying long‐term prognosis and optimal surveillance planning.

show abstract

IgG4‐positive extranodal marginal zone lymphoma arising in Hashimoto's thyroiditis: clinicopathological and cytogenetic features of a hitherto undescribed condition

Cited by 13 publications

References 22 publications

Marginal zone B-cell lymphoma: lessons from Western and Eastern diagnostic approaches

Marginal zone B-cell lymphoma: lessons from Western and Eastern diagnostic approaches

Clinical differences between IgG4 Hashimoto’s thyroiditis and primary thyroid lymphoma

Clinical characteristics and outcomes of IgG4‐positive marginal zone lymphoma: Systematic scoping review

Contact Info

Product

Resources

About