IgM-FTA test in syphilis in adults. Its relation to clinical findings.

Wilkinson, A. E.; Rodin, P.

doi:10.1136/sti.52.4.219

Cited by 23 publications

(18 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The non-reactive FTA-ABS IgM results may possibly be explained by competitive inhibition of IgM by immunoglobulin G (IgG). The persistence of reactivity in a comparable percentage has been observed by other investigators (Grin et al, 1974;Wilkinson and Rodin, 1976). The current results therefore suggest that FTA-ABS IgM titres are less reliable for assessing the effect of treatment than the course of the VDRL titres.…”

supporting

confidence: 83%

Quantitative evaluation of the FTA-ABS-IgM and VDRL test in treated and untreated syphilis.

Luger¹,

Schmidt²,

I³

1977

Sexually Transmitted Infections

View full text Add to dashboard Cite

supporting

confidence: 83%

Quantitative evaluation of the FTA-ABS-IgM and VDRL test in treated and untreated syphilis.

Luger¹,

Schmidt²,

I³

1977

Sexually Transmitted Infections

View full text Add to dashboard Cite

“…During the first several weeks of leutic infection, the immune response is suppressed (29,30), and the antibody response is restricted to a few polypeptides (31,32). In tertiary syphilis, as in Lyme disease, specific IgM has been detected after the development of specific IgG, although the responsible antigens have not been identified in syphilis (33,34). Similarly, in certain chronic parasitic infections, immunosuppression occurs in the illness (35), and specific IgM responses have been detected in the presence ofspecific IgG (35).…”

Section: Methodsmentioning

confidence: 93%

Antigens of Borrelia burgdorferi recognized during Lyme disease. Appearance of a new immunoglobulin M response and expansion of the immunoglobulin G response late in the illness.

Craft¹,

Fischer²,

Shimamoto³

et al. 1986

J. Clin. Invest.

356

174

View full text Add to dashboard Cite

Using immunoblots, we identified proteins ofBorrelia burgdorferi bound by IgM and IgG antibodies during Lyme disease. In 12 patients with early disease alone, both the IgM and IgG responses were restricted primarily to a 41-kD antigen. This limited response disappeared within several months. In contrast, among six patients with prolonged illness, the IgM response to the 41-kD protein sometimes persisted for months to years, and late in the illness during arthritis, a new IgM response sometimes developed to a 34-kD component of the organism. The IgG response in these patients appeared in a characteristic sequential pattern over months to years to as many as 11 spirochetal antigens. The appearance of a new IgM response and the expansion of the IgG response late in the illness, and the lack of such responses in patients with early disease alone, suggest that B. burgdorferi remains alive throughout the illness.

show abstract

“…[3][4][5][6][7][8][9] In contrast, Duncan and Kuhn,'°in a similar study using chimpanzees, found that production of specific antitreponemal IgM ceased spontaneously in 10 out of 24 animals who had received no treatment, and treponemal IgM reactivity in sera from patients with late syphilis.…”

Section: Introductionmentioning

confidence: 99%