Immunological responses in late syphilis.

Shannon, Richard P.; Copley, C G; Morrison, G. D.

doi:10.1136/sti.56.6.372

Cited by 4 publications

(4 citation statements)

References 13 publications

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“…Another explanation for this lack of sensitivity might be the fact that a surplus of IgG can inhibit IgM production in vivo (12). Our study confirms that testing for antitreponemal IgM is useful for detecting active disease early but also that the absence of IgM antibodies to treponemes does not imply that syphilis is absent (8,16,22).…”

Section: Discussionsupporting

confidence: 79%

Evaluation of the Captia enzyme immunoassays for detection of immunoglobulins G and M to Treponema pallidum in syphilis

1990

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Two new enzyme-linked immunosorbent assays (ELISA), one for the measurement of immunoglobulin G (IgG) (Captia Syphilis-G) and one for the measurement of IgM (Captia Syphilis-M), were evaluated for detecting antibodies to Treponema pallidum. Serum samples from 169 patients, 96 with various stages of untreated syphilis, 63 with treated syphilis, and 10 who were noninfected, were investigated. Ail sera were also examined by traditional treponemal and cardiolipin tests and by the fluorescent treponemal antibody absorption (FTA-ABS) test for 19S(IgM). The overall sensitivity of Captia Syphilis-G was 98.3%. The IgG ELISA was very sensitive (100%) in all stages of untreated syphilis, except in primary syphilis (82%). In ail diagnostic groups of syphilis, the reactivity of Captia Syphilis-M was similar to that of the 19S(IgM) FTA-ABS test, except in reinfections, in which the IgM capture ELISA was less sensitive. False-positive IgM capture ELISA results were not found in the 10 neonates born to mothers adequately treated for syphilis. However, of six serum samples containing rheumatoid factor, two were reactive in the Captia Syphilis-M test but not in the

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Section: Discussionsupporting

confidence: 79%

Evaluation of the Captia enzyme immunoassays for detection of immunoglobulins G and M to Treponema pallidum in syphilis

1990

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“…There are few reports (Joffe et al, 1968;Dewhurst, 1969;Shannon et al, 1980) of elderly patients with neurosyphilis being treated, and little reference is made to outcome in this group (Giles, 1980). In this report the treponemal serology status of 800 patients assessed at a psychogeriatric assessment unit is reviewed, and the findings discussed.…”

Section: Jean Antoine Boodhoomentioning

confidence: 92%

Syphilis Serology Screening in a Psychogeriatric Population

Boodhoo

1989

Br J Psychiatry

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The treponemal serological status of 800 patients above the age of 65 was reviewed. Twenty-one were found to be positive and the venereologists advised against treatment in all referred cases. The question is posed whether syphilis serology screening in the elderly mentally ill should be confined to those patients with obvious clinical manifestation of syphilis or with obscure psychiatric presentations.

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“…konnten Shannon und Kollegen bei keinem von 18 Patienten mit später Syphilis Treponemen spezifische IgM-Ak nachweisen[25]. Unsere Daten zeigen, dass der 19S-IgM-FTA-ABS Test auch bei TPPA Titern von < 1 : 20,000 negativ ausfallen kann und trotzdem eine noch aktive Infektion ± nachgewiesen durch das Auftreten einer konnatalen Syphilis ± der Mutter vorliegt.…”

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“…Niedrige VDRL-Titer schlieûen daher das Vorliegen einer behandlungsbedürftigen Infektion in der Schwangerschaft nicht aus. Es kann sich aber auch um persistierende Restbefunde nach adäquat behandelter Infektion oder um biologisch falschpositive Befunde handeln[27]. Immer wieder diskutiert wird die Bedeutung der Titerhöhe treponemenspezifischer Antikörper als möglicher Hinweis auf eine aktive Infektion.…”

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