II. On the secretion of saliva, chiefly on the secretion of salts in it

Langley, J. N.; Fletcher, H. M.

doi:10.1098/rstb.1889.0002

Cited by 9 publications

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Radiation-induced xerostomia in cancer patients.Effect on salivary and serum electrolytes

Dreizen

Brown

Handler

et al. 1976

Cancer

210

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Saliva and serum electrolyte concentrations were monitored in 30 patients given a course of xerostomia-producing cancer radiotherapy. The mean flow r a t e of stimulated whole saliva decreased 83.3% during a 6-week treatment period. The striking reduction in saliva o u t p u t was accompanied by significant increases in saliva Na+, C1-, Cat+, Mg" and Prot.-concentrations and by a decrease i n saliva HCO; content. The xerostomic saliva was more concentrated and had a greater salinity t h a n t h e pretreatment saliva in each instance. In contrast, none of t h e serum electrolytes measured was significantly altered by t h e subtotal salivary shutdown.Cancer 38:273-278, 1976.

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Radiation-induced xerostomia in cancer patients.Effect on salivary and serum electrolytes

Dreizen

Brown

Handler

et al. 1976

Cancer

210

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The permeability of mammalian salivary glands for organic non‐electrolytes

Amberson

Höber

1932

J. Cell. Comp. Physiol.

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The phenomena of glandular activity fall into two categories. We have to do, first, with the formation of specific substances, not present in the blood, which are elaborated within the gland cells, and appear in the secretion. Secondly, we observe the performance of osmotic work, by which materials already present in the blood are either concentrated or diluted in the secretion. The glands thus appear to exercise a choice between various blood constituents, permitting only certain of them to penetrate, and often concentrating those which do. A full understanding of the secretion mechanism must include, therefore, a knowledge of the characteristics of gland tissue which determine its permeability. I n an attempt to study certain of these characteristics we have investigated the permeability of the mammalian salivary gland (cat) for various organic non-electrolytes.Previous studies on the permeability of this gland have established the following facts. As regards inorganic ions, a series of reports (Rosemann, '27 ; Babkin, '28 ; Gregersen and Ingalls, '31) have shown that K passes from the blood into the saliva more readily than Na. At the slower secretion rates more K than Na may be present in the saliva, and all workers agree that its concentration considerably exceeds that in the blood serum. Conversely, the Na content is always below that present in the serum. Gregersen and Ingalls have shown that the salivary Na content rises as the

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Drittes Kapitel

Babkin¹

1928

Die Äussere Sekretion Der Verdauungsdrüsen

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II. On the secretion of saliva, chiefly on the secretion of salts in it

Cited by 9 publications

References 0 publications

Radiation-induced xerostomia in cancer patients.Effect on salivary and serum electrolytes

Radiation-induced xerostomia in cancer patients.Effect on salivary and serum electrolytes

The permeability of mammalian salivary glands for organic non‐electrolytes

Drittes Kapitel

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