III. Prolactin and calcium metabolism in the rat

Mattheij, J.A.M.; Sterrenberg, Lydi; Swarts, Hans J. M.

doi:10.1016/0024-3205(80)90480-4

Cited by 5 publications

(1 citation statement)

References 17 publications

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“…However, the exact mechanism of prolactin action still remains speculative. Prolactin has been shown to have a diverse array of actions in vertebrates which includes an increase in in testinal fluid and an increase in ion, sugar and amino acid transport [Nicoll, 1981;Bern, 1975;Ensor, 1978;Mattheij et al, 1980;Bisbee, 1981;Pang, 1981;Mainoya, 1975], In mammals, prolactin has been pro posed to be a modulator rather than a pri mary controlling factor of fluid and electro lyte metabolism. As alterations in ion, sugar and amino acid transport and hydration of lens have been known to play an important role in galactose cataractogenesis [Kinoshita, 1974], prolactin could be facilitating the transport of these important elements into the lens and thus cause an acceleration of the development of lens opacity.…”

Section: Discussionmentioning

confidence: 99%

Effect of Prolactin on Galactose Cataractogenesis

Tsui

Merola

et al. 1987

Ophthalmic Res

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Prolactin has been known to affect the water and electrolyte balance. Because increased lens hydration has been shown to be a common phenomenon in most, if not all types of cataracts, we have been interested in investigating a possible role of prolactin in sugar cataract induction and progression. For this study, we have used morphological and biochemical approaches. The prolactin delivery method involved intraperitoneal implantation of one or more pellets in Sprague-Dawley female rats. Following implantation of the desired number of prolactin or control (nonprolactin) pellets, animals were either fed galactose and lab chow, or lab chow diet. Gross morphological observations of whole lenses, slit-lamp examination of lenses and light microscopic analysis of lens sections showed that in the galactose-fed prolactin group, galactose associated alteration progressed faster and total opacification (mature cataract development) was achieved earlier than in the nonprolactin group. The levels of galactose and dulcitol were higher in the lenses of galactose-fed prolactin treated rats as compared to lenses from nonprolactin (control) rats. No significant difference in lens Na⁺–K⁺ ATPase activity between the prolactin and nonprolactin group was observed. Our results indicate that prolactin accelerates galactose-induced cataractogenesis in rats.

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Section: Discussionmentioning

confidence: 99%

Effect of Prolactin on Galactose Cataractogenesis

Tsui

Merola

et al. 1987

Ophthalmic Res

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Calcitonin as an Anorectic Agent

Freed

Bing

Andersen

et al. 1984

Psychoneuroendocrine Dysfunction

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Reference values for urinary calcium excretion and screening for hypercalciuria in children and adolescents

1984

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Hypercalciuria is of continuing interest as one of the risk factors for stone disease in children, but the definition, incidence and pathogenesis are controversial. Therefore reference values for the urinary calcium/creatinine (Ca/Cr) ratios were established in 564 healthy children aged 6-17.9 years during the fasting state (09.00 h) and in 236 of them also in the post-absorptive state about 2 h after lunch (14.00-16.00 h). The Ca/Cr ratios in both urine specimens were independent of age and sex, rendering it possible to determine a common normal range and to calculate centiles for Ca excretion in a large sample of healthy children and adolescents. To provide information about the incidence of hypercalciuria the Ca/Cr ratios of 1013 other apparently healthy children aged 6-17.9 years were measured during the post-absorptive state on two consecutive days. In 39 (3.8%) of them, 21 girls, and 18 boys, the Ca excretion was elevated in both urine specimens. Thirty-six of these children, all presenting without renal complaints, underwent further investigations to elucidate the possible mechanisms of the hypercalciuria. On the basis of the Ca/Cr concentration during the fasting state and the calciuric response to a standardised oral Ca tolerance test the children were subclassified into three groups: (1) Absorptive hypercalciuria (AH, n = 12): Increased calciuric response to the Ca load, but normal fasting Ca/Cr; (2) Renal hypercalciuria (RH, n = 8): Increased Ca/Cr after Ca load and during the fasting state; (3) Normal Ca excretion during the fasting state and after the Ca tolerance test, but increased sodium excretion (dietary hypercalciuria, DH, n = 16).(ABSTRACT TRUNCATED AT 250 WORDS)

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III. Prolactin and calcium metabolism in the rat

Cited by 5 publications

References 17 publications

Effect of Prolactin on Galactose Cataractogenesis

Effect of Prolactin on Galactose Cataractogenesis

Calcitonin as an Anorectic Agent

Reference values for urinary calcium excretion and screening for hypercalciuria in children and adolescents

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