2015
DOI: 10.4155/fso.15.81
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IKVAV-linked cell membrane-spanning peptide treatment induces neuronal reactivation following spinal cord injury

Abstract: Spinal cord regeneration following treatment with a novel membrane-spanning peptide (MSP) expressing the isoleucine-lysine-valine-alanine-valine (IKVAV) epitope was assessed in Balb-c mice. After hemilaminectomy and compression injury, mice were treated with IKVAV, IKVAV-MSP, peptide or vehicle control. Functional improvement was assessed using modified Basso, Beattie, and Bresnahan Scale (mBBB) and spinal cord segments were studied histologically 28 days after injury. IKVAV-MSP group scores increased signific… Show more

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Cited by 7 publications
(5 citation statements)
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“…q.d.) was administered once daily for the first 2 days, and additional doses were administered whenever mice showed signs of discomfort such as decreased activity and movement, self-chewing, excessive grooming, or anorexia ( Jellish et al, 2008 ; Kazemi et al, 2015 ). Gentamycin (20 mg/kg s.c., q.d.…”
Section: Methodsmentioning
confidence: 99%
“…q.d.) was administered once daily for the first 2 days, and additional doses were administered whenever mice showed signs of discomfort such as decreased activity and movement, self-chewing, excessive grooming, or anorexia ( Jellish et al, 2008 ; Kazemi et al, 2015 ). Gentamycin (20 mg/kg s.c., q.d.…”
Section: Methodsmentioning
confidence: 99%
“…Controlled application of fusogens initiates axon growth approximately one week after treatment; such growth becomes more stable over time and is long-term [ 32 ]. Various molecular reagents, such as chitosan nanospheres [ 33 ], PEG-biopolymer matrix [ 29 , 34 , 35 ], IKVAV transmembrane-spanning peptide [ 36 ], and olfactory mucosa autografts [ 37 ] have been utilised as scaffolds in chronic SCI models to facilitate neuronal regrowth across gaps in the transected spinal cords. In contrast, PEG serves as a genuine fusogen by stabilising the membranes of transected neurones at the site of spinal cord transection, leading to the fusion of these transected axons with neighbouring axons across the transection site.…”
Section: Spinal Cord Fusion (Scf): a New Technique For Sci Repair And...mentioning
confidence: 99%
“…Numerous molecular agents have been tested in different models of acute and chronic spinal cord injury. They include Chitosan nanospheres,[ 8 ] PEG-polyethylene glycol biopolymer matrix,[ 3 5 9 12 15 16 20 ] IKVAV membrane spanning peptide,[ 12 ] and olfactory mucosa autograft. [ 11 ] All were used in different chronic cord injury models, and neuronal growth occurred with all.…”
Section: How To Get Neurons To Grow Across the Severed Cord Endsmentioning
confidence: 99%