IL-10 −1082 G>A: a risk for prostate cancer but may be protective against progression of prostate cancer in North Indian cohort

Abstract

Our results support the emerging hypothesis that genetically determined immune activity may play a role in the pathophysiology of PCa. Our findings of high producer of IL-10 -1082 variants suggest initiation of PCa. Future studies in large cohort of different ethnicity PCa groups are warranted to establish definite associations with other cytokine gene polymorphisms.

IL-10 polymorphisms and prostate cancer risk: a meta-analysis

“…Third, not all studies including controls were in Hardy-Weinberg equilibrium. 20,22,24 Fourth, the association in this meta-analysis was investigated in all types of cases (hereditary, familial or sporadic PCa). There may be PCa-specific genetic effects among these cases but we could not obtain enough information to further estimate these effects.…”

“…Although three studies 20,22,24 did not follow the HardyWeinberg equilibrium, the summary ORs were not effectively altered with or without including these three studies. Moreover, no other single study influenced the overall results qualitatively as indicated by sensitivity analyses.…”

“…As a result, there were 10 studies retrieved on the basis of the above search criteria for PCa susceptibility related to IL-10 À1082 A4G, À819 C4T and À592 C4A polymorphisms. 9,[16][17][18][19][20][21][22][23][24] The main study characteristics are summarized in Table 1. There were three studies of subjects of Asian descent 20,22,24 and seven studies of subjects of Caucasian descent.…”

“…9,[16][17][18][19][20][21][22][23][24] The main study characteristics are summarized in Table 1. There were three studies of subjects of Asian descent 20,22,24 and seven studies of subjects of Caucasian descent. 9,[16][17][18][19]21,23 Among these studies, three studies have investigated only one SNP (McCarron et al considered -1082 A4G; Eder et al considered -592 C4A; and Omrania et al considered À1082 A4G), whereas three studies included two SNPs (Michaud et al considered À1082 A4G and À819 C4T; Wang et al considered À1082 A4G and À592 C4A; and Kesarwani et al considered À1082 A4G and À819 C4T).…”

“…A classical PCRrestriction fragment length polymorphism assay was conducted in two studies, 16,24 a TaqMan assay was used in five studies, 9,18,19,21,23 and an amplification refractory IL-10 polymorphisms and prostate cancer risk N Shao et al mutation system-PCR technique assay was used in two studies. 17,22 The last study adopted allele-specific oligonucleotide-PCR method. 20 In addition, there were four studies that investigated the association of IL-10 polymorphisms with PCa aggressiveness.…”