IL-10 Genotype Analysis in Patients with Behçet’s Disease

The impact of the IL-1β, IL-1Ra, IL-2, IL-6 and IL-10 gene polymorphisms on the development of Behcet's disease and their association with the phenotype

“…In a trial by Wallace et al in different ethnical groups, similar results were obtained. 4 While a study by Dilek et al reported that the IL-10 gene polymorphism could increase the host sensitivity for BD, another trial detected no difference between the patients and the controls, similar to our trial. 16,27 Another noticeable point in our trial was that among cases of BD, 21 of the 26 patients with IL-6 GG polymorphism that possessed a high proinflammatory activity also had IL-10 GG polymorphism, a type of polymorphism with a lower anti-inflammatory efficacy.…”

“…It usually has an onset between the age of 30 and 40 years. [3][4][5] The incidence of the disease among males and females is equal, considering the overall population, even if it varies between the countries. 13 The mean age was 37.8 ± 1.0 in our trial and the female to male ratio was 1.01.…”

“…2 The etiology is not clearly understood; however, the occurrence of the disease has been attributed to several causes, including infectious agents, vascular endothelial pathologies, immunologic and environmental factors, hormones and clotting factors. 3,4 Cytokine-producing cells were reported to be involved in the disease immunopathogenesis, and the cytokines were reported to be significantly involved in the occurrence and course of the disease. 5,6 The studies on etiopathogenesis reported results, establishing an association between the cytokine genes such as IL-l A and ␤, IL-8, IL-12, IL-10, the gene polymorphisms, which are significantly involved in the gene polymorphisms, and BD.…”

Insights into Behçet’s disease

“…The association of the IL-4 and IL-4Rα gene polymorphisms with the susceptibility in BD Turkish patients and healthy control subjects, display that the frequency of IL-4 (-1098 TG and -590 CT) genotypes was higher in the patients [18]. The study on promoter region of the IL-10 encoding gene polymorphisms in patients with BD from Middle East and UK populations showed that the IL-10 (-1082AA) genotype was weakly associated with BD [19].…”

Zytokine in der Diagnostik der Uveitis

“…Ein SNP in der Promotorregion des IL-10-Gens (Position -819) ist mit dem Morbus Behcet assoziiert[48]. Eine Kombination von spezifischen SNP's in zwei Zytokingenen (IFNg in der Position 874 und IL-10 in der Position -1082) führt zu einem ca.…”