IL‐17 and its role in inflammatory, autoimmune, and oncological skin diseases: state of art

Abstract

Recent data support the theory of the involvement of IL‐17 in the pathogenesis of several chronic inflammatory skin diseases (psoriasis, atopic dermatitis, acne, hidradenitis suppurativa) and autoimmune skin diseases (alopecia areata, vitiligo, bullous diseases). Even if the role of IL‐17 in inflammatory and autoimmune diseases has been reported extensively, its role in tumor is still controversial. Some reports show that Th17 cells eradicate tumors, while others reveal that they promote the initiation and early growth of tumors. Herein, we review the role of IL‐17 in the involvement of some common dermatologic diseases: psoriasis, atopic dermatitis, hidradenitis suppurativa, acne, vitiligo, melanoma, and nonmelanoma skin cancers.

Treatment of chronic alopecia areata with tildrakizumab: an open‐label pilot study

“…The partial response to tildrakizumab seen in two of nine participants adds to the existing literature supporting the role of IL‐17 in the pathogenesis of AA . The response rate to tildrakizumab is similar to that seen with cyclosporin 4 mg/kg .…”

“…Tildrakizumab is a high‐affinity monoclonal antibody targeting interleukin (IL)‐23 p19 . IL‐23 induces T‐helper 17 (Th17) cell proliferation that produces IL‐17, a proinflammatory cytokine linked to the pathogenesis of several autoimmune conditions . Janus kinase (JAK) 2 has also been demonstrated to be an intracellular mediator of IL‐23 cell surface receptor binding .…”

“…Janus kinase (JAK) 2 has also been demonstrated to be an intracellular mediator of IL‐23 cell surface receptor binding . Recent evidence supports the role of IL‐17 in the pathogenesis of AA, highlighting the potential therapeutic role by targeting IL‐23 …”

Recognition of Candida albicans and Role of Innate Type 17 Immunity in Oral Candidiasis

“…Association of C. albicans with cancer progression is less established; however, analysis of nationwide medical registries in Denmark and Taiwan have reported increased cancer risks upon C. albicans infection [155][156][157][158]. Inflammation triggered by C. albicans, in particular IL-17-driven, indeed may contribute to the tumorigenesis, as it has been shown for autoimmune disorders [159][160][161][162]. However, the role for innate and adaptive arms of immunity in C. albicans-driven tumorigenesis remains widely obscured and further research could elucidate this important question.…”

Biologics as a therapeutic approach for a Th17‐mediated severe dermatitis in skin barrier disorders

“…Furthermore, a link with IL‐17 has been reported in the pathogenesis of other chronic inflammatory and autoimmune skin diseases such as acne, hidradenitis supurativa, alopecia areata, vitiligo, and bullous disease. This opens the possibility of targeting IL‐17A to treat a wide range of skin disorders 5 …”