IL-17A (-197G/A) and IL-17F (7488T/C) gene polymorphisms and cancer risk in Asian population: a meta-analysis

Dai, Wei; Zhou, Quan; Tan, Xiaoheng; Sun, Changfu

doi:10.2147/ott.s62781

Cited by 11 publications

(5 citation statements)

References 30 publications

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“…Taken together, despite some limitations, the present meta-analysis provided a more precise estimation of the relationship between the IL-17 gene SNPs and gastric cancer risk compared with the individual studies, which also supports the previous findings (Dai et al, 2014). Furthermore, other possible causative variants in the IL-17 gene should be explored.…”

Section: Discussionsupporting

confidence: 88%

Meta-analysis of Associations between Interleukin-17 Gene Polymorphisms and Risk of Gastric Cancer

Sun

Liu³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Background: Previous studies have indicated that single nucleotide polymorphisms (SNPs) of the interleukin-17 (IL-17) gene are associated with an increased risk of gastric cancer. However, the findings were inconsistent. Materials and Methods: To provide a more reliable estimation of the association between SNPs in the IL-17 gene and the susceptibility to gastric cancer, we searched PubMed, CNKI, and Wan Fang databases and selected finally six studies covering 2,366 cases and 3,205 controls to perform a meta-analysis. Results: Statistical analyses showed that an rs2275913 polymorphism within the IL-17A gene was significantly associated with an increased risk of gastric cancer using a generalized odds ratio (ORG, a model-free approach). Moreover, we also found that the 'A' allele carriers of IL-17A rs2275913 had a significant link with clinicopathological features. However, no significant positive signals were observed in the association analysis of the rs3748067 and rs763780 polymorphisms with the risk of gastric cancer in IL-17A and IL-17F, respectively. Conclusions: Despite some limitations, the present meta-analysis provided a more precise estimation of the relationship between the IL-17 gene SNPs and gastric cancer risk compared with individual studies.

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Section: Discussionsupporting

confidence: 88%

Meta-analysis of Associations between Interleukin-17 Gene Polymorphisms and Risk of Gastric Cancer

Sun

Liu³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…IL-17A and IL-17F are the most important members; they all located at 6q12 and comprise three exons and two introns (Iwakura et al, 2011). Previous studies have shown that over-expression of IL-17A and IL-17F contributes to the development of various cancers, such as pancreatic, gastric, and lung cancers (Cully, 2014;Dai et al, 2014;Zarogoulidis et al, 2014;Kaabachi et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

IL-17A and IL-17F polymorphisms and gastric cancer risk: a meta-analysis

Li¹,

Liu²,

Cao³

et al. 2015

Genet. Mol. Res.

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ABSTRACT. We conducted a meta-analysis of eligible studies to estimate the association between gastric cancer risk and rs2275913G>A IL-17A and rs763780T>C IL-17F polymorphisms. We searched the relevant studies in both Chinese and English through PubMed, the Web of Science, the Cochrane Library, and EMBASE up to January 1, 2014, including 3939 cases and 5407 controls. Seven eligible case-control studies were selected, including seven studies on rs2275913G>A IL-17A and four studies on rs763780T>C IL-17F. The rs2275913 AG [odds ratio (OR) = 1.50, 95% confidence interval (95%CI) = 1.04-2.15] and GG (OR = 1.40, 95%CI = 1.00-1.96) genotypes were significantly associated with increased risk of gastric cancer compared with the AA genotype. The rs763780 TC (OR = 1.47, 95%CI = 1.32-1.64) and TT (OR = 1.49, 95%CI = 1.11-1.99) genotypes can influence gastric cancer risk. Subgroup analysis showed that rs2275913 GG (OR = 1.35, 95%CI = 1.05-1.73) and rs763780 TC (OR= 1.44, 95%CI = 1.20-1.75) genotypes were not significantly associated with increased risk of gastric cancer in Japanese populations. Our meta-analysis is the first to indicate that the rs2275913G>A and rs763780T>C polymorphisms are risk factors for gastric cancer development.

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“… 4 In addition, several previous meta-analyses have evaluated a specific gene polymorphism and risk for all cancer types, respectively. 5 – 7 …”

Section: Introductionmentioning

confidence: 99%

−148 C/T polymorphism of Axin2 contributes to a decreased risk of cancer: evidence from a meta-analysis

Zhong

Pan

Shi

et al. 2015

OTT

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Several studies have reported an association between −148 C/T polymorphism of Axis inhibition protein 2 (Axin2) and cancer risk; however, the results are inconsistent. In this study, a meta-analysis was performed to assess the association between −148 C/T polymorphism of Axin2 and susceptibility to cancer. Published case–control and cohort-based studies from PubMed, Embase, Wanfang, and CNKI were retrieved, and data were manually extracted. The odds ratios (ORs) and 95% confidence intervals (CIs) of the included studies were pooled. Begg’s and Egger’s tests were used to evaluate publication bias. Cumulative and recursive cumulative meta-analyses (CMA) were performed as evidence accumulated to investigate the trends and stability of the effect size. Nine articles with 1,664 cases and 1,796 controls were included. The pooled effect size showed an association between −148 C/T polymorphism and the risk of cancer (dominant model, OR: 0.72, 95% CI: 0.63–0.83; allele model, OR: 0.81, 95% CI: 0.73–0.90). CMA showed an association trend, and the recursive CMA indicated that more evidence is needed to make conclusions about significance. In a subgroup analysis, a significant association between −148 C/T polymorphism and low cancer susceptibility was detected for lung cancer (dominant model, 0.69, 95% CI: 0.56–0.85; recessive model, OR: 0.75, 95% CI: 0.56–0.99; allele model, 0.76, 95% CI: 0.66–0.86). The −148 C/T polymorphism was also associated with low cancer susceptibility among Asians (dominant model, OR: 0.68, 95% CI: 0.57–0.81; recessive model, OR: 0.75, 95% CI: 0.56–0.99; allele model, OR: 0.76, 95% CI: 0.66–0.86). The Axin2 −148 C/T polymorphism was found to be significantly associated with a decreased risk of cancer, particularly lung cancer, in Asians and population-based controls. Thus, Axin2 should be considered as a potential therapeutic target for preventing tumor growth.

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IL-17A (-197G/A) and IL-17F (7488T/C) gene polymorphisms and cancer risk in Asian population: a meta-analysis

Cited by 11 publications

References 30 publications

Meta-analysis of Associations between Interleukin-17 Gene Polymorphisms and Risk of Gastric Cancer

Meta-analysis of Associations between Interleukin-17 Gene Polymorphisms and Risk of Gastric Cancer

IL-17A and IL-17F polymorphisms and gastric cancer risk: a meta-analysis

−148 C/T polymorphism of Axin2 contributes to a decreased risk of cancer: evidence from a meta-analysis

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IL-17A (-197G/A) and IL-17F (7488T/C) gene polymorphisms and cancer risk in Asian population: a meta-analysis

Cited by 11 publications

References 30 publications

Meta-analysis of Associations between Interleukin-17 Gene Polymorphisms and Risk of Gastric Cancer

Meta-analysis of Associations between Interleukin-17 Gene Polymorphisms and Risk of Gastric Cancer

IL-17A and IL-17F polymorphisms and gastric cancer risk: a meta-analysis

&minus;148 C/T polymorphism of Axin2 contributes to a decreased risk of cancer: evidence from a meta-analysis

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−148 C/T polymorphism of Axin2 contributes to a decreased risk of cancer: evidence from a meta-analysis