2023
DOI: 10.1371/journal.ppat.1011847
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IL-17RA promotes pathologic epithelial inflammation in a mouse model of upper respiratory influenza infection

Zahrasadat Navaeiseddighi,
Jitendra Kumar Tripathi,
Kai Guo
et al.

Abstract: The upper respiratory tract (nasopharynx or NP) is the first site of influenza replication, allowing the virus to disseminate to the lower respiratory tract or promoting community transmission. The host response in the NP regulates an intricate balance between viral control and tissue pathology. The hyper-inflammatory responses promote epithelial injury, allowing for increased viral dissemination and susceptibility to secondary bacterial infections. However, the pathologic contributors to influenza upper respi… Show more

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Cited by 4 publications
(1 citation statement)
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“…Protection mediated by IAV vaccine-primed Th17 cells has also been demonstrated in mice [59]. A separate set of observations directly correlated IL-17 production during IAV infection with increased lung immunopathology in mice [60], a relationship that has been observed in many subsequent studies [59,[61][62][63][64]. On the other hand, IL-17 has been shown to be an important component promoting optimal B cell responses in the lung during IAV infection in mice [65,66].…”
Section: Th17 Responsesmentioning
confidence: 76%
“…Protection mediated by IAV vaccine-primed Th17 cells has also been demonstrated in mice [59]. A separate set of observations directly correlated IL-17 production during IAV infection with increased lung immunopathology in mice [60], a relationship that has been observed in many subsequent studies [59,[61][62][63][64]. On the other hand, IL-17 has been shown to be an important component promoting optimal B cell responses in the lung during IAV infection in mice [65,66].…”
Section: Th17 Responsesmentioning
confidence: 76%