IL-18 and Cutaneous Inflammatory Diseases

Lee, Ji Hyun; Cho, Dae Ho; Park, Hyun Jeong

doi:10.3390/ijms161226172

Cited by 83 publications

(81 citation statements)

References 105 publications

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“…However, improper regulation of IL-18 can potentially lead to inflammation and destruction of self. This cytokine is synthetized as an inactive form that requires to be processed by caspase-1 into its active form [37] .…”

Section: The Il-18 Axismentioning

confidence: 99%

See 1 more Smart Citation

Obesity, Type 1 Diabetes, and Psoriasis: An Autoimmune Triple Flip

Granata

Skarmoutsou²,

Trovato³

et al. 2016

Pathobiology

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Obesity, type 1 diabetes, and psoriasis are wide-ranging health problems. Genetics, epigenetics, and environmental factors together with immune disturbances are involved in these diseases. The white adipose tissue is an active endocrine organ, secreting a wide variety of soluble mediators called adipokines that have a central role in the relationship between adipose tissue and immune system. Inflammatory cytokines, including the IL-23/IL-17 and IL-18 axes, and microRNAs are involved in many processes, including immunity and inflammation, thus having a major role in the onset of these three diseases. In this review, we present an overview of the roles of adipokines, cytokines, and microRNAs in the pathogenesis and the progression of these three diseases.

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Section: The Il-18 Axismentioning

confidence: 99%

“…A growing number of studies support an involvement of the IL-18 axis in the pathogenesis of psoriasis [37] . For reasons not fully understood, patients with an organ-specific autoimmune disease have increased risks of develop-ing autoimmune responses against other organs or tissues.…”

mentioning

confidence: 99%

Obesity, Type 1 Diabetes, and Psoriasis: An Autoimmune Triple Flip

Granata

Skarmoutsou²,

Trovato³

et al. 2016

Pathobiology

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“…These results suggest that IL-18 is involved in the secretion of TSLP. A previous study reported that secreted IL-18 activated IL-18 receptors to increase the expression of nuclear factor κβ, 47 which induced TSLP production. 48 In addition, skin damage in humans has been reported to induce an increase in TSLP.…”

Section: Discussionmentioning

confidence: 95%

Ultraviolet B eye irradiation aggravates atopic dermatitis via adrenocorticotropic hormone and NLRP3 inflammasome in NC/Nga mice

Hiramoto

Yamate

Yokoyama

2017

Photoderm Photoimm Photomed

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Summary Background Ultraviolet (UV) B irradiation has been shown to improve atopic dermatitis (AD). However, the relationship between UVB eye irradiation and AD is not known. This issue was addressed using a mouse model of AD. Methods The eyes of NC/Nga mice were irradiated with UVB at a dose of 1.0 kJ/m2 using a 20SE sunlamp for the duration of the experimental period. Results AD symptoms deteriorated upon UVB eye irradiation. The levels of adrenocorticotropic hormone (ACTH) in the plasma and nucleotide‐binding domain and leucine‐rich‐containing family, pyrin domain‐containing (NLRP)3 and neutrophil markers in the skin were increased in UVB‐irradiated mice. Treatment with inhibitors of ACTH, caspase‐1, interleukin‐18, and thymic stromal lymphopoietin (TSLP) partly reversed the effects of irradiation, with the greatest improvement observed upon ACTH inhibition. The NLRP3 inflammasome was implicated in the effects of UVB irradiation. Conclusions UVB eye irradiation causes AD symptom deterioration, which is likely mediated by ACTH and the activity of the inflammasome.

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“…The purpose of inflammation is to eliminate the initial causes or damaged cells and begin tissue repair. However, long-term inflammation caused by genetic or environmental factors can lead to chronic cutaneous diseases such as psoriasis, rosacea, atopic dermatitis, and alopecia areata, which are associated with uncontrolled immune activity [19]. A variety of cytokines play an important role in the inflammatory pathogenesis of skin.…”

Section: Roles Of Erythroid Differentiation Regulator 1 (Erdr1) Onmentioning

confidence: 99%

“…In fact, increased expression of IL-18 and its receptor were observed on lesional skin tissues from patients diagnosed with inflammatory cutaneous diseases such as psoriasis, rosacea, atopic dermatitis, or alopecia areata [19]. Moreover, plasma IL-18 concentration has been linked to the severity of these diseases.…”

Section: Roles Of Erythroid Differentiation Regulator 1 (Erdr1) Onmentioning

confidence: 99%

Roles of Erythroid Differentiation Regulator 1 (Erdr1) on Inflammatory Skin Diseases

Houh

Kim

Park

et al. 2016

IJMS

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Erythroid Differentiation Regulator 1 (Erdr1) is known as a hemoglobin synthesis factor which also regulates cell survival under conditions of stress. In addition, previous studies have revealed the effects of Erdr1 on cancer progression and its negative correlation with interleukin (IL)-18, a pro-inflammatory cytokine. Based on this evidence, the therapeutic effects of Erdr1 have been demonstrated in several inflammatory skin diseases such as malignant skin cancer, psoriasis, and rosacea. This article reviews the roles of Erdr1 in skin inflammation, suggesting that Erdr1 is a potential therapeutic molecule on inflammatory disorders.

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IL-18 and Cutaneous Inflammatory Diseases

Cited by 83 publications

References 105 publications

Obesity, Type 1 Diabetes, and Psoriasis: An Autoimmune Triple Flip

Obesity, Type 1 Diabetes, and Psoriasis: An Autoimmune Triple Flip

Ultraviolet B eye irradiation aggravates atopic dermatitis via adrenocorticotropic hormone and NLRP3 inflammasome in NC/Nga mice

Roles of Erythroid Differentiation Regulator 1 (Erdr1) on Inflammatory Skin Diseases

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