IL-1B −31T>C promoter polymorphism is associated with gastric stump cancer but not with early onset or conventional gastric cancers

Abstract

It has been reported that interleukin-1beta (IL-1B) genes play a crucial role in the genetic predisposition to gastric cancer although there is no information about their role in different subtypes of gastric cancer. We performed single nucleotide polymorphism analysis of IL-1B in 241 gastric cancers including early onset gastric cancers (EOGC), conventional gastric cancers, and gastric stump cancers (GSCs) as well as 100 control patients, using real-time polymerase chain reaction and sequence analysis. The C allele was present in 60% of EOGCs, 59% of conventional gastric cancers, and 90% of GSCs, compared to 62% in the control group. Interestingly, there was no difference between early onset and conventional gastric cancer with respect to the IL-1B −31T>C polymorphism distribution. A statistically significant difference in the presence of the C allele compared to the control group was found in patients with gastric stump cancer ( p= 0.008) with the T allele conferring protection against gastric stump cancer. In summary, we have shown that the IL-1B −31C allele promoter polymorphism is significantly associated with gastric stump cancer compared to the control group. Although several molecular differences have been identified between conventional gastric cancer and early onset gastric cancer, the IL-1B −31 allele distribution is similar between these two groups.

Interleukin‐1B 31 C>T polymorphism combined with Helicobacter pylori‐modified gastric cancer susceptibility: evidence from 37 studies

“…Of the remaining 38 publications, three were eliminated, due to reporting duplicate data 17, 18, 19. Ultimately, 37 studies from 35 publications 6, 10, 14, 15, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50 including 6108 cases and 8980 controls were included in the meta‐analysis (Fig. 1).…”

Does remnant gastric cancer really differ from primary gastric cancer? A systematic review of the literature by the Task Force of Japanese Gastric Cancer Association

“…Moreover, high-level microsatellite instability was significantly more frequent in RGC after Billroth II anastomosis than after Billroth I anastomosis. Sitarz et al reported that the IL-1B-31T [ C promoter polymorphism is associated with RGC but not with early-onset or primary gastric cancer [48]. A statistically significant difference in the presence of the C allele compared with the control group was found in patients with RGC, with the T allele conferring protection against gastric stump cancer.…”

Molecular Pathology of Gastric Carcinoma

“…The genetic polymorphism of interleukin-1 ␤ , a proinflammatory cytokine gene, was studied in GC patients. While some studies demonstrated that the most proinflammatory genotypes of interleukin-1 ␤ are positively associated with GC [21] ; other reports do not support these results, which might be explained by the population-specific cancer risks [22] . A polymorphism of interleukin 1 receptor antagonist (IL1RN), IL10 and TNF genes was also identified to be associated with increased risk for GC, which makes it possible to define a specific genetic profile associated with the highest risk for GC [23] .…”