IL-1R8: A molecular brake of anti-tumor and anti-viral activity of NK cells and ILC

Effect of bovine colostrum liposomes on the bioavailability of immunoglobulin G and their immunoregulatory function in immunosuppressed BALB/c mice

“…Toll-like receptors (TLRs) play a crucial role in immune and inflammatory responses, which may further trigger the activation of several transcription factors related to immune and inflammatory responses, such as nuclear transcription factor-κB (NF-κB), mitogen-activated protein kinase (MAPK), and extracellular signal-regulated kinase (ERK), to promote the amplification of the inflammation and immunity reactions of the body. 47 Several clinical studies have suggested that the mechanism by which bovine colostrum exerts an immune function might result from its anti-inflammatory effects on various intestinal inflammatory diseases. 22,48,49 Previously, Lu and colleagues investigated the effect of IgG on serum cytokines levels through different administration methods, and the results showed that oral administration with IgG exhibited a pro-inflammatory function in rabbits, as manifested by upregulation of the pro-inflammatory cytokines levels ( e.g.…”

“…46 Toll-like receptors (TLRs) play a crucial role in immune and inflammatory responses, which may further trigger the activation of several transcription factors related to immune and inflammatory responses, such as nuclear transcription factor-κB (NF-κB), mitogen-activated protein kinase (MAPK), and extracellular signal-regulated kinase (ERK), to promote the amplification of the inflammation and immunity reactions of the body. 47 Several clinical studies have suggested that the mechanism by which bovine colostrum exerts an immune…”

Research Progress on the Role and Mechanism of IL-37 in Liver Diseases

“…[28] In addition, the expression of IL-1R8 has been found in monocytes, B lymphocytes, Natural Killer (NK) cells. [29] IL-37 exerted antiinflammatory effects via IL-1R8 by inhibiting the p38, ERK, JNK NF-κB：Fyn：MAPK：TAK1 and mTOR activation, and activating anti-inflammation pathways including AMPK, PTEN, Mer, STAT3 and p62. In IL-37 transgenic mouse (IL-37tg mouse) models, IL-1R8 deficiency causes mice to be susceptible to endotoxemia, and the anti-inflammatory activity of IL-37 is impaired by silencing either IL-1R8 or IL-18Rα.…”

Possible correlated signaling pathways with chronic urate nephropathy: A review

“…Toll-like receptors (TLR) can mediate immune response by recognizing different related molecular patterns, participate in inflammatory response [75] and immune cell regulation, [76] and are closely related to innate immune response [77] and adaptive immune response. [78] When the TLR signaling pathway is stimulated by UA, [79] LPS, [80] and peptidoglycan, [81] the TLR can protect the host by recognizing pathogens and activating downstream pathways to mediate immune responses. TLR signaling pathway is associated with TRIF, [82] TRAF3 [83] class MyD88 nondependent pathway and MyD88 [84] induced activation of P38, [85] JNK, [86] Mitogen-activated protein kinase (MAPK), [87] TAK1/TBK1, [88] NF-kB, [89] and IRF5 [90] activation are closely related.…”