IL‑1α, IL‑6 and IL‑8 serum values in patients with chronic suppurative otitis media

Şerban, Roxana; Filip, Cristina; Rădulescu, Luminiţa; Bădescu, Magda; Diaconescu, Bogdan Mihail; Cobzeanu, Mihail Dan; Cobzeanu, Bogdan Mihail

doi:10.3892/etm.2021.10660

Cited by 4 publications

(3 citation statements)

References 20 publications

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“…In a study by Serban et al, the authors recorded high serum levels of IL-1α, IL-6, and IL-8 in all otitis media groups compared to the healthy group. In the same study, IL-1α had the highest value in patients with cholesteatoma recidivism (Serban et al, 2021). IL-6 is a cytokine produced by various cells and triggers cell proliferation and differentiation.…”

Section: Introductionmentioning

confidence: 79%

Investigation of EGF, IL1-α and IL-6 levels and selected hematological parameters (NLR, MPV) in patients with the chronic cholesteatomatous otitis media

et al. 2022

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In this study we aimed to investigate epidermal growth factor (EGF), interleukin (IL1)-α and IL-6 levels, and hematological parameters in the serum samples of patients with chronic cholesteatomatous otitis media (CCOM). This prospective included 40 patients who underwent surgery due to CCOM between June 2020 and May 2021. The stage of middle ear cholesteatoma was determined on each chart using the EAONO/JOS system. The control group comprised of 30 adults who were scheduled for septoplasty over the same period in our hospital, had no otological complaints, and had normal otological findings. The demographic, clinical, and laboratory data of the patients were obtained from the electronic medical record system of our hospital. The serum EGF, IL1-α and IL-6 levels, and hematological parameters (neutrophil-lymphocyte ratio (NLR) and mean platelet volume (MPV)) were compared between the CCOM and control groups. Seven patients had Stage 1 and 33 patients had Stage 2 middle ear cholestatoma. There was no statistically significant difference between the CCOM and control groups in terms of age and gender (p=0.092 and p=0.616, respectively). The serum EGF and IL1-α levels of the CCOM group were statistically significantly higher than those of the control group (p=0.047 and p=0.013, respectively). No statistically significant difference was observed in the serum IL-6 levels of the CCOM and control groups (p=0.675). There was also no significant difference between the CCOM and control groups in terms of the mean NLR and MPV values (p=0.887 and p=0.164, respectively). There was no significant difference between the Stage 1 and Stage 2 cholesteatoma subgroups in terms of the mean EGF, IL1-α, IL-6 levels (p=0.204, p=0.557 and p=0.613, respectively), and the mean NLR and MPV values (p=0.487, p=0.439, respectively). Increased serum EGF and IL1-α levels in patients with CCOM suggest that these cytokines may play a role in cholesteatomatous epithelial hyperproliferation.

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Section: Introductionmentioning

confidence: 79%

Investigation of EGF, IL1-α and IL-6 levels and selected hematological parameters (NLR, MPV) in patients with the chronic cholesteatomatous otitis media

et al. 2022

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“…Papers with different topics, and 1 paper for which data related to chronic otitis media could not be extracted. Finally, eight papers were included in our meta-analysis [20][21][22][23][24][25][26][27][28][29]. The literature screening process is shown in Figure 1.…”

Section: The Results and General Characteristics Of The Included Lite...mentioning

confidence: 99%

A meta-analysis on genetic susceptibility to chronic otitis media

Cao,

Yang,

et al. 2023

Preprint

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Chronic otitis media (COM) is known for its high prevalence (approximately 80% in children) and is thought to share common genetic risk factors, which means that there is a need to systematically study susceptibility genes associated with COM. We screened studies associated with COM genes between January 2019 and February 2023. Ten papers with 932 patients meeting the criteria were finally included, and a case-control analysis of the relationship between gene polymorphisms and COM susceptibility was performed using RevMan 5.3 software. The literature on the relationship between polymorphisms in genes related to susceptibility to chronic otitis media and chronic otitis media was tested for consistency and data merged according to different genes, and some genes were found to be polymorphic. Attitude, VEGF and Nrf2 were correlated with chronic otitis media (P < 0.05). Gene polymorphism and chronic otitis media may be related to the nationality of patients; TNF- α, IL-10, VEGF and Nrf2 may promote the formation of granulation tissue during the inflammatory phase and participate in the repair process of chronic inflammation; high expression of Nrf2 in the middle ear tissue of chronic otitis media is related to the pathogenesis of chronic otitis media.

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“…У всех пациентов выполнено количественное определение содержания в сыворотке крови интерлейкина-6, С-реактивного белка, общего холестерина, холестерина липопротеинов высокой плотности, холестерина липопротеинов низкой плотности, триацилглицеринов, апобелка-А, апобелка-В, липопротеина (а). Установлено, что показатели концентрации интерлейкина-6, липопротеина (а), апобелка-В и липопротеинов низкой плотности достоверно увеличены у пациентов с хроническим эпитимпано-антральным гнойным средним отитом с холестеатомой по сравнению с аналогичными значениями представителей контрольной группы пациентов (p<0,05 Медиаторы воспаления, в том числе интерлейкин-6 (ИЛ-6), играют центральную роль в патогенезе хронического эпитимпано-антрального гнойного среднего отита и холестеатомы, поддерживая системный и местный воспалительный ответ [3]. Наряду с этим ИЛ-6 является одним из наиболее значимых цитокинов в развитии нарушений липидного обмена [4, c. 467; 5, с.…”

Section: резюме _____________________________________________________...unclassified

Clinical and Pathogenetic Information Value of a Combined Study of Laboratory Indicators of Inflammatory and the State of Lipid Metabolism in Patients with Chronic Suppurative Otitis Media Involving Epitympanum

Юревич¹,

Шестакова²,

Муравейник³

2022

Лабораторная Диагностика. Восточная Европа

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Цель. Установить характер сочетанных изменений показателей биомаркеров воспаления и липидного (липопротеинового) спектра сыворотки крови как одного из потенциально возможных механизмов формирования хронического эпитимпаноантрального гнойного среднего отита (H66.2, МКБ-10).Материалы и методы. Для установления показателей лабораторных тестов, отражающих синдром воспаления и состояние липидного (липопротеинового) спектра сыворотки крови, проведено одномоментное когортное исследование контингента пациентов из 56 человек, включающего в себя 42 пациентов с диагнозом «хронический эпитимпано-антральный гнойный средний отит» (с холестеатомой и без) и 14 практически здоровых человек, составивших контрольную группу, которая по возрастно-половому составу соответствовала группе пациентов, страдающих гнойным отитом.Результаты. У всех пациентов выполнено количественное определение содержания в сыворотке крови интерлейкина-6, С-реактивного белка, общего холестерина, холестерина липопротеинов высокой плотности, холестерина липопротеинов низкой плотности, триацилглицеринов, апобелка-А, апобелка-В, липопротеина (а). Установлено, что показатели концентрации интерлейкина-6, липопротеина (а), апобелка-В и липопротеинов низкой плотности достоверно увеличены у пациентов с хроническим эпитимпано-антральным гнойным средним отитом с холестеатомой по сравнению с аналогичными значениями представителей контрольной группы пациентов (p<0,05).Выводы. Сочетанное исследование факторов воспаления и липидного спектра сыворотки крови показало увеличение ее атерогенного потенциала на фоне усугубления выраженности метаболических проявлений воспалительного процесса, что может являться важным патогенетическим звеном формирования холестеатомы и ее рецидивирования. Полученные данные являются основанием к проведению дальнейших исследований на предмет установления лабораторно-диагностической и прогностической значимости выявленных метаболических нарушений. Purpose. Determine the concentration levels of inflammation indicators (interleukin-6, C-reactive protein) and lipid spectrum of blood serum in patients with chronic suppurative otitis media involving epitympanum, both with and without cholesteatoma, who underwent surgical treatment at the Republican Scientific and Practical Center of Otorhinolaryngology from August to December 2021.Materials and methods. To establish the indicators of laboratory tests reflecting the inflammation syndrome and the state of the lipid (lipoprotein) spectrum of the blood serum, a one-stage cohort study of a contingent of patients of 56 people, including 42 patients with a diagnosis of "Chronic suppurative otitis media involving epitympanum" (with and without cholesteatoma) was carried out and 14 practically healthy people who made up the control group, which in terms of age and sex composition corresponded to the group of patients suffering from suppurative otitis media.Results. All patients underwent quantitative determination of serum levels of interleukin-6, C-reactive protein, total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, triacylglycerols, apoprotein-A, apoprotein-B, lipoprotein (a). It was established that the concentrations of interleukin-6, lipoprotein (a), apoprotein-B and low-density lipoproteins were significantly increased in patients with chronic suppurative otitis media involving epitympanum with cholesteatoma compared with similar values in the control group of patients (p<0.05).Conclusions. It remains relevant to conduct further studies to establish the levels of interleukins and lipid spectrum indicators in order to identify markers-predictors of cholesteatoma recurrence in patients with chronic suppurative otitis media involving epitympanum.

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IL‑1α, IL‑6 and IL‑8 serum values in patients with chronic suppurative otitis media

Cited by 4 publications

References 20 publications

Investigation of EGF, IL1-α and IL-6 levels and selected hematological parameters (NLR, MPV) in patients with the chronic cholesteatomatous otitis media

Investigation of EGF, IL1-α and IL-6 levels and selected hematological parameters (NLR, MPV) in patients with the chronic cholesteatomatous otitis media

A meta-analysis on genetic susceptibility to chronic otitis media

Clinical and Pathogenetic Information Value of a Combined Study of Laboratory Indicators of Inflammatory and the State of Lipid Metabolism in Patients with Chronic Suppurative Otitis Media Involving Epitympanum

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