IL-36 Cytokines: Their Roles in Asthma and Potential as a Therapeutic

Dong, Hongna; Hao, Yuqiu; Li, Wei; Yang, Wei; Gao, Peng

doi:10.3389/fimmu.2022.921275

Cited by 14 publications

(11 citation statements)

References 157 publications

(248 reference statements)

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“…NETs regulate inflammatory cytokines in response to alarmins. NETs stimulate macrophages to secret IL‐1β, recruit neutrophils, thereby further promoting their own progression 12 . Moreover, NETs can stimulate airway epithelial cells to secret IL‐1 family cytokines, such as IL‐36.…”

Section: Local Expression Of Il‐36 and Netsmentioning

confidence: 99%

Local neutrophil and eosinophil extracellular traps formation in pyodermatitis pyostomatitis vegetans

Yamamoto

2023

Experimental Dermatology

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Pyodermatitis pyostomatitis vegetans is a rare inflammatory condition, affecting the skin and/or mucous membrane. Some cases include both skin and mucous involvement, whereas others develop either skin or mucous lesions only. The typically affected areas are the scalp, face, trunk and extremities, including the flexural areas and umbilicus. Clinical features show erosive granulomatous plaques, keratotic plaques with overlying crusts and pustular lesions. Among mucous lesions, oral mucosa is most frequently involved, and gingival erythema, shallow erosions, cobblestone‐like papules on the buccal mucosa or upper hard palate of the oral cavity are also observed. Some of the lesions assume a ‘snail track’ appearance. Although there are several similarities between pyodermatitis pyostomatitis vegetans and other diseases, that is pyoderma gangrenosum, pemphigus vegetans and pemphigoid vegetans, the histopathological features of pyodermatitis pyostomatitis vegetans are unique in that epidermal hyperplasia, focal acantholysis and dense inflammatory infiltrates with intraepidermal and subepidermal eosinophilic microabscesses are observed. Direct immunofluorescence findings are principally negative. Activated neutrophils are supposed to play an important role in the pathogenesis of pyodermatitis pyostomatitis vegetans. The expression of IL‐36 and neutrophil extracellular traps (NETs) was observed in the lesional skin, and additionally, eosinophil extracellular traps (EETs) was detected in pyodermatitis pyostomatitis vegetans. A possible pathogenic role of NETs and EETs in the innate immunity and autoinflammatory aspects of pyodermatitis pyostomatitis vegetans was discussed.

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Section: Local Expression Of Il‐36 and Netsmentioning

confidence: 99%

Local neutrophil and eosinophil extracellular traps formation in pyodermatitis pyostomatitis vegetans

Yamamoto

2023

Experimental Dermatology

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“…NETs stimulate macrophages to secrete interleukin (IL)-1β and recruit neutrophils, thereby further promoting their own progression. 31 Moreover, NETs can stimulate airway epithelial cells to secrete IL-1 family cytokines such as IL-36. Neutrophil elastase cleaves IL-36 receptor antagonist into its highly active form.…”

Section: Ne Ts Formati On In Cutaneous Lu Pusmentioning

confidence: 99%

“…NETs regulate inflammatory cytokines in response to alarmins. NETs stimulate macrophages to secrete interleukin (IL)‐1β and recruit neutrophils, thereby further promoting their own progression 31 . Moreover, NETs can stimulate airway epithelial cells to secrete IL‐1 family cytokines such as IL‐36.…”

Section: Nets Formation In Cutaneous Lupusmentioning

confidence: 99%

Role of neutrophils in cutaneous lupus erythematosus

Yamamoto

2023

The Journal of Dermatology

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There are various types of cutaneous lupus erythematosus (CLE), either with or without the association of systemic lupus erythematosus (SLE). In some of the subtypes of cutaneous lupus, histopathology reveals neutrophil infiltration in the lesional skin; however, the significance of neutrophils in CLE is not yet fully elucidated. Recent studies have shown that neutrophil extracellular traps (NETs) formation by activated neutrophils is observed in several types of CLE, including lupus panniculitis, subacute lupus erythematosus, and acute lupus erythematosus, although the number of reports is small. Excessive NETosis, due to either increased NETs formation or defective clearance of NETs, may play a role in the induction of autoimmunity and autoantibody production in SLE, as well as endothelial damage, thrombus formation, and vascular damage in the lesional skin. CLE is an excessive interferon‐driven autoimmune disease. Plasmacytoid dendritic cells are located in lupus erythematosus skin and contribute to the etiology of skin lesions as a main producing cell of type I interferon. Neutrophils, monocytes, and keratinocytes also produce type I interferon via several triggers. Neutrophils play an important role in the innate immune response in SLE. In this review, several types of CLE with neutrophil infiltration, as well as the role of neutrophils are discussed.

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“…Increasing evidence suggests that IL-36 family cytokines are key mediators of a variety of in ammatory diseases and are closely related to the development of diseases [9,10]. They have become a hot spot and frontier in in ammation and immunity research.…”

Section: Introductionmentioning

confidence: 99%

Correlations between IL-36 family cytokines in peripheral blood and subjective and objective assessment results in patients with allergic rhinitis

Qin

Jiang

et al. 2023

Preprint

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Background As a newly described member of interleukin (IL)-1 superfamily, IL-36 has become a hot spot and frontier in inflammation and immunity research. However, whether IL-36 is correlated with the subjective and objective assessment results of allergic rhinitis (AR) and then affects the severity of AR remains unknown. So, this study aimed to investigate the correlations between their concentration levels and subjective and objective assessment results, and to further analyze their possible mechanisms in the development of AR. Methods An enzyme-linked immunosorbent assay (ELISA) was used to detect the concentration levels of the IL-36 family cytokines IL36α, IL-36β, IL-36γ, IL-36Ra, and IL-38 in the peripheral blood of patients with AR. The condition of patients with AR was assessed by 22-item sino-nasal outcome test (SNOT-22) score, visual analogue scale (VAS) scores for disease severity, and serum inhalant allergen immunoglobulin E (IgE) detection. Correlations between IL-36 family cytokines and subjective and objective assessment results in patients with AR were analyzed. Results The concentration level of IL-36α in the peripheral blood of patients with AR was the highest, and the concentration level of IL-36β was the lowest. The concentration level of IL-36α was higher in juvenile patients than in adult patients, and there was a difference in IL-36Ra level between the perennial allergen group and the seasonal allergen group. There was a positive correlation between IL-36α level and IL-36γ, IL-36γ level and IL-36Ra, IL-36Ra level and IL-38, and IL-36β level was positively correlated with IL-36Ra and IL-38. IL-36α level was positively correlated with VAS score for nasal congestion symptom, and IL-36β level was positively correlated with VAS scores for ocular itching and eye pain symptoms. However, there was no correlation between the concentration levels of all cytokines in the IL-36 family and SNOT-22 score, total VAS score for severity of illness, the number of positive inhalant allergens, or the highest positive intensity of allergen specific IgE (sIgE). Conclusion Peripheral blood IL-36 family cytokines play an important role in the disease of AR, and the concentration levels of IL-36α and IL-36β were related to the severity of symptoms in patients with AR.

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IL-36 Cytokines: Their Roles in Asthma and Potential as a Therapeutic

Cited by 14 publications

References 157 publications

Local neutrophil and eosinophil extracellular traps formation in pyodermatitis pyostomatitis vegetans

Local neutrophil and eosinophil extracellular traps formation in pyodermatitis pyostomatitis vegetans

Role of neutrophils in cutaneous lupus erythematosus

Correlations between IL-36 family cytokines in peripheral blood and subjective and objective assessment results in patients with allergic rhinitis

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