IL-36α suppresses proliferation of ovarian cancer cells

Chang, Lei; Guo, Ruixia; Zhang, Yuan

doi:10.1177/1010428317706918

Cited by 20 publications

(25 citation statements)

References 22 publications

(28 reference statements)

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“…Specifically, we validated melatonin action on two genes involved in the immune response and tumor progression. Il1f6 shows an important pro-inflammatory role in chronic immune disorders 58,59 and recently its role in cancer has been described 59,60 . This gene is a member of the IL-1 family of cytokines, also composed of two other agonists, IL-36-β (IL-1F8) and IL-36γ (IL-1F9) and one antagonist IL-36Ra (IL-1F5) 61,62 .…”

Section: Discussionmentioning

confidence: 99%

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RNA-Seq transcriptome analysis shows anti-tumor actions of melatonin in a breast cancer xenograft model

Jardim‐Perassi

Alexandre

Sonehara

et al. 2019

Sci Rep

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Melatonin is a pleiotropic anti-cancer molecule that controls cancer growth by multiple mechanisms. RNA-Seq can potentially evaluate therapeutic response and its use in xenograft tumor models can differentiate the changes that occur specifically in tumor cells or in the tumor microenvironment (TME). Melatonin actions were evaluated in a xenograft model of triple-negative breast cancer. Balb/c nude mice bearing MDA-MB-231 tumors were treated with melatonin or vehicle. RNA-Seq was performed on the Illumina HiSeq. 2500 and data were mapped against human and mouse genomes separately to differentiate species-specific expression. Differentially expressed (DE) genes were identified and Weighted Gene Co-expression Network Analysis (WGCNA) was used to detect clusters of highly co-expressed genes. Melatonin treatment reduced tumor growth (p < 0.01). 57 DE genes were identified in murine cells, which represented the TME, and were mainly involved in immune response. The WGCNA detected co-expressed genes in tumor cells and TME, which were related to the immune system among other biological processes. The upregulation of two genes (Tnfaip8l2 and Il1f6) by melatonin was validated in the TME, these genes play important roles in the immune system. Taken together, the transcriptomic data suggests that melatonin anti-tumor actions occur through modulation of TME in this xenograft tumor model.

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Section: Discussionmentioning

confidence: 99%

“…Chang et al . showed that IL-36 gene therapy can inhibit the growth in xenograft model of epithelial ovarian cancer 59 . Moreover, its upregulation was able to regress the tumor masses in fibrosarcoma mouse model and reduce the Ki-67 expression 60 .…”

Section: Discussionmentioning

confidence: 99%

RNA-Seq transcriptome analysis shows anti-tumor actions of melatonin in a breast cancer xenograft model

Jardim‐Perassi

Alexandre

Sonehara

et al. 2019

Sci Rep

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“…Of the remaining members of this family, IL-36α and IL-36β, to date, three studies in the literature have suggested that IL-36α may also have tumor-suppressive effects. IL-36α was shown to suppress the growth of ovarian cancer cells (120). Moreover, reduced expression of IL-36α has also been shown to be associated with poor prognosis in colon (121) and hepatocellular cancer (122).…”

Section: Interleukin-36mentioning

confidence: 99%

IL-1 Family Members in Cancer; Two Sides to Every Story

2019

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The IL-1 family of cytokines currently comprises of seven ligands with pro-inflammatory activity (IL-1α and IL-1β, IL-18, IL-33, IL-36α, IL-36β, IL-36γ) as well as two ligands with anti-inflammatory activity (IL-37, IL-38). These cytokines are known to play a key role in modulating both the innate and adaptive immunes response, with dysregulation linked to a variety of autoimmune and inflammatory diseases. Given the increasing appreciation of the link between inflammation and cancer, the role of several members of this family in the pathogenesis of cancer has been extensively investigated. In this review, we highlight both the pro- and anti-tumorigenic effects identified for almost all members of this family, and explore potential underlying mechanisms accounting for these divergent effects. Such dual functions need to be carefully assessed when developing therapeutic intervention strategies targeting these cytokines in cancer.

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“…IL-36γ is a recognized T-bet target in myeloid cells, and T-bet can instigate decreases in tumor growth by promoting dendritic cell (DC)-mediated ectopic lymphoid organogenesis in a manner that is dependent on IL-36γ (101, 102). There is the mounting evidence that suggests IL-36 cytokines can act as tumor suppressors, although it is yet to be deciphered whether this function has any connection to angiogenic regulation (103, 104).…”

Section: Il-36 Il-37 and Il-38—the Story Emerging So Farmentioning

confidence: 99%

IL-1 Family Cytokine Regulation of Vascular Permeability and Angiogenesis

2019

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The IL-1 family of cytokines are well-known for their primary role in initiating inflammatory responses both in response to and acting as danger signals. It has long been established that IL-1 is capable of simultaneously regulating inflammation and angiogenesis, indeed one of IL-1's earliest names was haemopoeitn-1 due to its pro-angiogenic effects. Other IL-1 family cytokines are also known to have roles in mediating angiogenesis, either directly or indirectly via induction of proangiogenic factors such as VEGF. Of note, some of these family members appear to have directly opposing effects in different tissues and pathologies. Here we will review what is known about how the various IL-1 family members regulate vascular permeability and angiogenic function in a range of different tissues, and describe some of the mechanisms employed to achieve these effects.

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IL-36α suppresses proliferation of ovarian cancer cells

Cited by 20 publications

References 22 publications

RNA-Seq transcriptome analysis shows anti-tumor actions of melatonin in a breast cancer xenograft model

RNA-Seq transcriptome analysis shows anti-tumor actions of melatonin in a breast cancer xenograft model

IL-1 Family Members in Cancer; Two Sides to Every Story

IL-1 Family Cytokine Regulation of Vascular Permeability and Angiogenesis

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