IL-4 induces the intracellular expression of the α chain of the high-affinity receptor for IgE in in vitro–generated dendritic cells

Evidence for a differential expression of the FcεRIγ chain in dendritic cells of atopic and nonatopic donors

“…The impressive formation of an intracellular FcεRIα pool in immature DCs supports our previous observations, showing constitutive intracellular FcεRIα expression in freshly isolated LCs and a modest induction in DCs generated from CD34 + progenitors, but no surface expression (23,36). Thus, we propose that preformed intracellular FcεRIα, in contrast to monocytes, is characteristic for immature DCs.…”

Human Airway Smooth Muscle Cells Express the High Affinity Receptor for IgE (FcεRI): A Critical Role of FcεRI in Human Airway Smooth Muscle Cell Function

“…Indeed, preliminary data from our laboratory revealed that incubation of ASM cells with various IgE concentrations results in Fc⑀RI ␣-chain mRNA up-regulation (data not shown). Furthermore, Th2 cytokines, particularly IL-4, have been shown to play a positive role on the transcription of Fc⑀RI ␣-chain in human mast cells (29,30), human eosinophils obtained from atopic dermatitis subjects (31), and in dendritic cells (32). Whether a similar effect occurs in ASM cells is unknown.…”

The high-affinity IgE receptor (FcεRI): a critical regulator of airway smooth muscle cells?

“…Mast cells from IgE-deficient mice express low levels of Fc⑀RI, which suggests that the basal levels are under the control of other mechanisms (111). Cytokines, particularly IL-4, have been shown to play a positive role in the transcription of Fc⑀RI ␣-chain in human mast cells (106), human eosinophils from atopic dermatitis subjects (104), and human dendritic cells (30). In mice, however, IL-4 and also IL-10 decrease Fc⑀RI expression specifically affecting FcR ␤-, but not FcR ␣-or FcR ␥-, subunits (32,93).…”