IL-5 Predominant in Bronchoalveolar Lavage Fluid and Peripheral Blood in a Patient with Acute Eosinophilic Pneumonia.

Yamaguchi, Shinjiro; Okubo, Yoshio; Hossain, Mahboob; Honda, Takayuki; Kubo, Keishi; Sekiguchi, Morie; Takatsu, Kiyoshi

doi:10.2169/internalmedicine.34.65

Cited by 21 publications

(20 citation statements)

References 1 publication

(1 reference statement)

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“…The number of reports describing AEP cases has recently increased and several of these have demonstrated the elevation of IL-5 levels in serum and BAL fluid [4][5][6]. Some reports have described the role of IL-5 in the pathogenesis or disease activity of AEP [4,17].…”

Section: Discussionmentioning

confidence: 99%

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Increased vascular endothelial growth factor in acute eosinophilic pneumonia

Nishigaki

Fujiuchi²,

Yamazaki³

et al. 2003

Eur Respir J

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Acute eosinophilic pneumonia (AEP) is associated with the presence of diffuse pulmonary infiltrates on the chest radiograph and an increased number of eosinophils and an elevation of interleukin (IL)-5 levels in bronchoalveolar lavage (BAL) fluid. Vascular endothelial growth factor (VEGF) is a constitutively expressed protein encoded by messenger ribonucleic acid in human eosinophils and is released following stimulation with IL-5. However, the roles of IL-5 and VEGF in the pathogenesis or activity of this disease have not been clarified.The authors investigated the cells and the levels of these two factors in BAL fluid in five AEP patients and five normal controls before and after corticosteroid treatment.The absolute number of eosinophils?mL -1 , IL-5 and VEGF levels in patients before treatment were higher than in controls (53.8 versus 0.3610 4 ?mL -1 , 490.1 versus 5.2 pg?mL -1 and 643.0 versus 133.9 pg?mL -1 , respectively). IL-5 and VEGF rapidly decreased to the control level in parallel with clinical improvement. The relationship between eosinophilia and IL-5 and VEGF levels was strongly significant.Elevated interleukin-5 in the lung may initiate the recruitment of eosinophils and enhance the release of mediators, such as vascular endothelial growth factor from eosinophils, which, in turn, increases the permeability of blood vessels. Eur Respir J 2003; 21: 774-778.

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Section: Discussionmentioning

confidence: 99%

“…The number of reports describing AEP cases has recently increased and several of these have demonstrated elevation of interleukin (IL)-5 levels in serum and BAL fluid [4][5][6].…”

mentioning

confidence: 99%

Increased vascular endothelial growth factor in acute eosinophilic pneumonia

Nishigaki

Fujiuchi²,

Yamazaki³

et al. 2003

Eur Respir J

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“…An adequate history with respect to cigarette smoking was available in 28 cases; 10 patients were nonsmokers and 18 were smokers. Of the 18 occurrences in smokers, 9 met our criteria for AEPfollowing cigarette smoking ( Table 1); 8 of these 9 reports originated from Japan (20)(21)(22)(23)(24)(25). The ninth case was reported by Godding and colleagues who described AEP in a 14-year-old girl who recently had begun smoking cigarettes, although the authors did not identify smoking as a precipitating cause of AEPin their report (26).…”

Section: Discussionmentioning

confidence: 99%

Acute Eosinophilic Pneumonia Following Cigarette Smoking.

et al. 2000

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Twocases of acute eosinophilic pneumoniafollowing cigarette smoking are analyzed for characteristic features. The first patient noted dyspnea 14 days after initiation of smoking. The second patient noted dyspnea 12 days after beginning to smoke. Both cases had characteristic features including occurrence at an age younger than 30 years; less than 1 month duration of cigarette smoking before onset of disease ; and no identifiable cause of acute eosinophilic pneumoniaapart from smoking. Webelieve that acute eosinophilic pneumonia following cigarette smoking, which has characteristic features as described above, should be considered as a distinct subtype of AEP. (Internal Medicine 39: 830-833, 2000)

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“…An array of both Th2 and Th1 cytokines are elevated in the BAL fluid in AEP, including IL-1ra, IL-2, IL-5, IL-10, IL-12, IL-13, and IL-18, perhaps reflecting the known pluripotent secretory potential of eosinophils (3,76,180). In particular, elevated BAL fluid levels of IL-5, the key cytokine promoting differentiation, migration, and survival of eosinophils, are associated with AEP (120,134,155,184,215). Cationic granule proteins and inflammatory lipid mediators are detectable in the urine of subjects with AEP (136).…”

Section: Aepmentioning

confidence: 99%

Eosinophilic Pneumonias

2012

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SUMMARY This review starts with discussions of several infectious causes of eosinophilic pneumonia, which are almost exclusively parasitic in nature. Pulmonary infections due specifically to Ascaris , hookworms, Strongyloides , Paragonimus , filariasis, and Toxocara are considered in detail. The discussion then moves to noninfectious causes of eosinophilic pulmonary infiltration, including allergic sensitization to Aspergillus , acute and chronic eosinophilic pneumonias, Churg-Strauss syndrome, hypereosinophilic syndromes, and pulmonary eosinophilia due to exposure to specific medications or toxins.

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IL-5 Predominant in Bronchoalveolar Lavage Fluid and Peripheral Blood in a Patient with Acute Eosinophilic Pneumonia.

Cited by 21 publications

References 1 publication

Increased vascular endothelial growth factor in acute eosinophilic pneumonia

Increased vascular endothelial growth factor in acute eosinophilic pneumonia

Acute Eosinophilic Pneumonia Following Cigarette Smoking.

Eosinophilic Pneumonias

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