IL-5 secretion by allergen-stimulated CD4+ T cells in primary culture: Relationship to expression of allergic disease

Till, Stephen J.; Dickason, R; Huston, David P.; Humbert, Marc; Robinson, David S.; Larché, Mark; Durham, Stephen R.; Kay, A. B.; Corrigan, Christopher

doi:10.1016/s0091-6749(97)70085-x

Cited by 115 publications

(123 citation statements)

References 23 publications

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“…We previously showed that IL-5 secretion in this model is dependent on CD4+ T cells and elevated in subjects with allergic rhinitis relative to control subjects. 17 These data confirmed that fluticasone is a potent inhibitor of allergen-driven IL-5 secretion by T cells in vitro (inhibitory concentration of 50% of between 10 -9 and 10 -10 mol/L), either through an effect on T cells themselves, an indirect effect on antigen-presenting cells, or both.…”

Section: Discussionsupporting

confidence: 72%

Nasal eosinophilia and IL-5 mRNA expression in seasonal allergic rhinitis induced by natural allergen exposure: Effect of topical corticosteroids☆☆☆★★★

Masuyama

Till

Jacobson

et al. 1998

Journal of Allergy and Clinical Immunology

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Section: Discussionsupporting

confidence: 72%

Nasal eosinophilia and IL-5 mRNA expression in seasonal allergic rhinitis induced by natural allergen exposure: Effect of topical corticosteroids☆☆☆★★★

Masuyama

Till

Jacobson

et al. 1998

Journal of Allergy and Clinical Immunology

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“…IgE synthesis has been shown to be enhanced by IL-4 secreted by Th2 cells, and suppressed by IFN-γ produced by Th1 cells [2, 3, 4]. Consistent with this, the IL-4 production is increased in allergic patients, whereas IFN-γ production is diminished or unchanged [5, 6, 7, 8, 9, 10]. However, the profile of cytokine production is considerably altered with age.…”

Section: Introductionmentioning

confidence: 89%

Development of the Capacity of Peripheral Blood Mononuclear Cells to Produce IL-4, IL-5 and IFN-γ upon Stimulation with House Dust Mite in Children with Atopic Dermatitis

Kimura¹,

Yamaide²,

Tsuruta³

et al. 2002

Int Arch Allergy Immunol

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Background: Imbalances of IL-4 and IFN-γ production are widely known to increase IgE synthesis in allergic individuals, and IL-5 is known to play a critical role in the pathogenesis of various allergic diseases. However, little is known about how Th cells specific to house dust mite (HDM) develop the capacity to produce these cytokines in children with atopic dermatitis (AD). Objective: This study aims to clarify when HDM-specific Th cells develop the capacity to produce IL-4, IL-5 and IFN-γ in children with AD. Methods: The production of IL-4, IL-5 and IFN-γ by peripheral blood mononuclear cells (PBMCs) upon stimulation with HDM was measured in 91 children with AD and 37 control subjects. The changes in the cytokine production with age were analyzed transectionally and longitudinally. Results: IL-4 production by HDM-stimulated PBMCs in children with AD was already increased before age 1. Thereafter, it continuously rose until reaching a near-maximum level at age 2. Growth-related changes in the production of IL-5 resembled those in the production of IL-4 and peaked at age 1. The production of these cytokines was very low in control subjects up to age 2 and then gradually increased, albeit never above the levels measured in AD children. The production of IFN-γ in children with AD reached a near-maximum level during the first year of life and diminished after age 3. Although IFN-γ production in controls was lower than that in AD children during infancy, it continuously rose even after age 3 and surpassed the levels measured in AD children. The level of serum HDM-specific IgE antibody began to increase after age 1 following the rise of IL-4 production. Essentially the same relationship among IL-4, IFN-γ and IgE synthesis was seen in a longitudinal study of 6 AD infants, in whom HDM-specific IgE was initially negative but later turned positive. Conclusions: These findings suggest that the capacity of HDM-specific Th cells to produce IL-4, IL-5 and IFN-γ develops and effectively matures during the first 3 years of life in children with AD.

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“…C D4-positive T lymphocytes have been suggested to play an integral role in the pathophysiology of bronchial asthma (1,2). Immunopathologic studies demonstrate an accumulation of CD4-positive T lymphocytes, especially Th2, in airway mucosa (3).…”

Section: Intervention Of Thymus and Activation-regulated Chemokinementioning

confidence: 99%

Intervention of Thymus and Activation-Regulated Chemokine Attenuates the Development of Allergic Airway Inflammation and Hyperresponsiveness in Mice

Kawasaki

Takizawa²,

Yoneyama

et al. 2001

The Journal of Immunology

245

168

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Thymus- and activation-regulated chemokine (TARC; CCL17) is a lymphocyte-directed CC chemokine that specifically chemoattracts CC chemokine receptor 4-positive (CCR4+) Th2 cells. To establish the pathophysiological roles of TARC in vivo, we investigated here whether an mAb against TARC could inhibit the induction of asthmatic reaction in mice elicited by OVA. TARC was constitutively expressed in the lung and was up-regulated in allergic inflammation. The specific Ab against TARC attenuated OVA-induced airway eosinophilia and diminished the degree of airway hyperresponsiveness with a concomitant decrease in Th2 cytokine levels. Our results for the first time indicate that TARC is a pivotal chemokine for the development of Th2-dominated experimental allergen-induced asthma with eosinophilia and AHR. This study also represents the first success in controlling Th2 cytokine production in vivo by targeting a chemokine.

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IL-5 secretion by allergen-stimulated CD4+ T cells in primary culture: Relationship to expression of allergic disease

Cited by 115 publications

References 23 publications

Nasal eosinophilia and IL-5 mRNA expression in seasonal allergic rhinitis induced by natural allergen exposure: Effect of topical corticosteroids☆☆☆★★★

Nasal eosinophilia and IL-5 mRNA expression in seasonal allergic rhinitis induced by natural allergen exposure: Effect of topical corticosteroids☆☆☆★★★

Development of the Capacity of Peripheral Blood Mononuclear Cells to Produce IL-4, IL-5 and IFN-γ upon Stimulation with House Dust Mite in Children with Atopic Dermatitis

Intervention of Thymus and Activation-Regulated Chemokine Attenuates the Development of Allergic Airway Inflammation and Hyperresponsiveness in Mice

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