IL-6 secretion of CD4+ T cells stimulated by LC3-positive extracellular vesicles in human epithelial ovarian cancer

Zhu, Xiulin; Wang, Hao-Jue; Wang, Xuru; Wu, Di; Ji, Xuan; Xu, Li; Yang, Qi; Guo, Jie-Ying; Yan, Rong; Pan, Ning; Cai, Yefeng

doi:10.1007/s12094-022-02883-y

Cited by 4 publications

(4 citation statements)

References 32 publications

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“…Only articles published in English were included. After the exclusion of duplicate, irrelevant journal articles and non-journal articles, 39 articles on exosome and EOC were selected for bibliometric analysis; 36 of which were original articles ( Zhang et al, 2016a ; Meng et al, 2016b ; Zhang et al, 2016b ; Labani-Motlagh et al, 2016 ; Ying et al, 2016 ; Chen et al, 2017 ; Hu et al, 2017 ; Li et al, 2017 ; Wu et al, 2017 ; Chen et al, 2018 ; Qiu et al, 2018 ; Zhang et al, 2018 ; Zhou et al, 2018 ; Zhang et al, 2019a ; Keserű et al, 2019 ; Tang et al, 2019 ; Zhu et al, 2019 ; Cheng et al, 2020 ; Li et al, 2020 ; Lu et al, 2020 ; Luo and Gui, 2020 ; Maeda et al, 2020 ; Masoumi-Dehghi et al, 2020 ; Alharbi et al, 2021 ; Xiong et al, 2021a ; Cai et al, 2021 ; Gao et al, 2021 ; Li et al, 2021 ; Liu et al, 2021 ; Ma et al, 2021 ; Zhu et al, 2022a ; Chen et al, 2022 ; Jeon et al, 2022 ; Lai et al, 2022 ; Yang et al, 2022 ), and the rest of them were review articles ( Li and Wang, 2017 ; Lucidi et al, 2020 ; Shiao et al, 2021 ). The first English article is “Characterization of exosomes derived from ovarian cancer cells and normal ovarian epithelial cells by nanoparticle tracking analysis” in 2015 ( Zhang et al, 2016a ).…”

Section: Resultsmentioning

confidence: 99%

The current trend of exosome in epithelial ovarian cancer studies: A bibliometric review

Baghban

Ullah²,

Nabipour³

2023

Front. Pharmacol.

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Background: Epithelial ovarian cancer (EOC) is the most common type of ovarian cancer. About 90% of ovary tumors are epithelial. The current treatment for EOC involves surgical debulking of the tumors followed by a combination of chemotherapy. While most patients achieve complete remission, many EOCs will recur and develop chemoresistance. The cancer cells can adapt to several stress stimuli, becoming resistant. Therefore, new ways to fight resistant cells during the disease are being studied. Recently, exosomes, which reflect cell behavior in normal and pathological conditions such as epithelial ovarian cancer, are of academic interest as new biomarkers for diagnosis and therapy. Consequently, the current study aimed to investigate the research output of exosomes in EOC.Method: A bibliometric method was used for analyzing publications on exosome and epithelial ovarian cancer from the beginning to 15 October 2022 by searching keywords in Scopus, PubMed and Google scholar. Annual scientific publications, authors, citations, journals, co-authorships, and keywords co-occurrence were analyzed and plotted using Microsoft Office Excel and VOS viewer. 39 original journal articles and 3 reviews have been published since 2015 up to 15 October 2022.Results: The findings showed that China is the top country in research output, international collaborations, organization, author, and sponsorship. The top journals were the Journal of Ovarian Research, Oncotarget, and Tumor Biology, all in the United States. The top institution was Shanghai Jiao Tong University in China. The top author was Xipeng Wang. Co-occurrence analysis showed that academics’ interest is toward:1) 1) Exosomes as prognostic biomarkers of EOC as well as their role in the proliferation and migration of cells. 2) The role of exosomes in metastasis through different mechanisms; 3) The role of exosomes in epithelial-mesenchymal transition of ovarian cancer cells; 4) The diagnostic role of EVs in EOC; and 5) Conferring chemoresistance in EOC through the exosomal transfer of miRNAs.Conclusion: Research on the exosome and EOC has an increasing trend, and China is much more involved than other countries in research, financial support, and international cooperation. These findings could aid researcher in understanding novel ideas and subjects interested by sponsors in this field.

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Section: Resultsmentioning

confidence: 99%

The current trend of exosome in epithelial ovarian cancer studies: A bibliometric review

Baghban

Ullah²,

Nabipour³

2023

Front. Pharmacol.

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“…These findings demonstrate the associations of LC3+ EV levels and the percentage of HSP90a+ LC3+ EVs with elevated IL-6 in the ascites of EOC patients. HSP90a on human EOC LC3+ EVs stimulates IL-6 production by CD4+ T cells via TLR2 (143). In their study, Zhang et al detected a specific group of tissue-resident memory T cells (Trm) characterized by the presence of both TIM-3 and CXCL13 markers within EOC samples.…”

Section: T Cellsmentioning

confidence: 96%

“…These findings demonstrate the associations of LC3+ EV levels and the percentage of HSP90α+ LC3+ EVs with elevated IL-6 in the ascites of EOC patients. HSP90α on human EOC LC3+ EVs stimulates IL-6 production by CD4+ T cells via TLR2 ( 143 ). In their study, Zhang et al.…”

Section: The Biological Roles and Functions Of Different Immune Cells...mentioning

confidence: 99%

Recent advances in understanding the immune microenvironment in ovarian cancer

Chen,

Yang,

et al. 2024

Front. Immunol.

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The occurrence of ovarian cancer (OC) is a major factor in women’s mortality rates. Despite progress in medical treatments, like new drugs targeting homologous recombination deficiency, survival rates for OC patients are still not ideal. The tumor microenvironment (TME) includes cancer cells, fibroblasts linked to cancer (CAFs), immune-inflammatory cells, and the substances these cells secrete, along with non-cellular components in the extracellular matrix (ECM). First, the TME mainly plays a role in inhibiting tumor growth and protecting normal cell survival. As tumors progress, the TME gradually becomes a place to promote tumor cell progression. Immune cells in the TME have attracted much attention as targets for immunotherapy. Immune checkpoint inhibitor (ICI) therapy has the potential to regulate the TME, suppressing factors that facilitate tumor advancement, reactivating immune cells, managing tumor growth, and extending the survival of patients with advanced cancer. This review presents an outline of current studies on the distinct cellular elements within the OC TME, detailing their main functions and possible signaling pathways. Additionally, we examine immunotherapy rechallenge in OC, with a specific emphasis on the biological reasons behind resistance to ICIs.

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“…CD4 + T cells. Studies have shown that multiple tumor-derived extracellular vesicles can act on CD4 + T cells [29,30]. As for GC, in a retrospective study, the researchers examined the correlation between exosomal PD-L1 and T cell counts in the plasma of 31 patients with metastatic GC before they underwent chemotherapy [15].…”

Section: Gc Cells-derived Evs Communicate With Immune Cellsmentioning

confidence: 99%

Extracellular vesicles mediated gastric cancer immune response: tumor cell death or immune escape?

Yang,

Wei,

Wei

2024

Cell Death Dis

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Gastric cancer (GC) is a major global health issue, being the fifth most prevalent cancer and the third highest contributor to cancer-related deaths. Although treatment strategies for GC have diversified, the prognosis for advanced GC remains poor. Hence, there is a critical need to explore new directions for GC treatment to enhance diagnosis, treatment, and patient prognosis. Extracellular vesicles (EVs) have emerged as key players in tumor development and progression. Different sources of EVs carry different molecules, resulting in distinct biological functions. For instance, tumor-derived EVs can promote tumor cell proliferation, alter the tumor microenvironment and immune response, while EVs derived from immune cells carry molecules that regulate immune function and possess tumor-killing capabilities. Numerous studies have demonstrated the crucial role of EVs in the development, immune escape, and immune microenvironment remodeling in GC. In this review, we discuss the role of GC-derived EVs in immune microenvironment remodeling and EVs derived from immune cells in GC development. Furthermore, we provide an overview of the potential uses of EVs in immunotherapy for GC.

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IL-6 secretion of CD4+ T cells stimulated by LC3-positive extracellular vesicles in human epithelial ovarian cancer

Cited by 4 publications

References 32 publications

The current trend of exosome in epithelial ovarian cancer studies: A bibliometric review

The current trend of exosome in epithelial ovarian cancer studies: A bibliometric review

Recent advances in understanding the immune microenvironment in ovarian cancer

Extracellular vesicles mediated gastric cancer immune response: tumor cell death or immune escape?

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