Il10 and poly‐<scp>dl</scp>‐lactide‐ɛ‐caprolactone conduits in critical size nerve defect bridging—An experimental study

Leibig, Nico; Boyle, Veronika; Kraus, Daniel; Stark, G. B.; Penna, Vincenzo

doi:10.1002/micr.22423

Cited by 3 publications

(2 citation statements)

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“…In addition, the SFI value was determined to track the change in motor function after nerve grafting. Although some limitations of the SFI value have been questioned, the SFI scale is still used to objectively assess and provide sequential information about the recovery of sciatic nerve function after nerve transection injury (Varejao et al ., ), even in very recently published studies (Das et al ., ; Leibig et al ., ; Liu et al ., ). In this study, we noted that the SFI value was significantly larger in the MSC–ECM group than in the scaffold group at 8–12 weeks after nerve grafting, suggesting that BMSC‐derived ECM had promoting effects on motor function restoration.…”

Section: Discussionmentioning

confidence: 99%

Application of marrow mesenchymal stem cell-derived extracellular matrix in peripheral nerve tissue engineering

Huang

et al. 2016

J Tissue Eng Regen Med

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To advance molecular and cellular therapy into the clinic for peripheral nerve injury, modification of neural scaffolds with the extracellular matrix (ECM) of peripheral nerves has been established as a promising alternative to direct inclusion of support cells and/or growth factors within a neural scaffold, while cell-derived ECM proves to be superior to tissue-derived ECM in the modification of neural scaffolds. Based on the fact that bone marrow mesenchymal stem cells (BMSCs), just like Schwann cells, are adopted as support cells within a neural scaffold, in this study we used BMSCs as parent cells to generate ECM for application in peripheral nerve tissue engineering. A chitosan nerve guidance conduit (NGC) and silk fibroin filamentous fillers were respectively prepared for co-culture with purified BMSCs, followed by decellularization to stimulate ECM deposition. The ECM-modified NGC and lumen fillers were then assembled into a chitosan-silk fibroin-based, BMSC-derived, ECM-modified neural scaffold, which was implanted into rats to bridge a 10 mm-long sciatic nerve gap. Histological and functional assessments after implantation showed that regenerative outcomes achieved by our engineered neural scaffold were better than those achieved by a plain chitosan-silk fibroin scaffold, and suggested the benefits of BMSC-derived ECM for peripheral nerve repair. Copyright © 2016 John Wiley & Sons, Ltd.

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Section: Discussionmentioning

confidence: 99%

Application of marrow mesenchymal stem cell-derived extracellular matrix in peripheral nerve tissue engineering

Huang

et al. 2016

J Tissue Eng Regen Med

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“…There are a large number of reports using critical gap models, including bridging with engineered neural tissue using Schwann cells and dADSCs, 14,15 bridging with collagen tubes and Schwann cell transplantation, 16 bridging with chitosan tubes, 17,18 and bridging with poly(L-lactide-co-ε-caprolactone) tubes. 19,20 A common aspect of these reports is that better nerve regeneration is demonstrated through intervention, by introducing cells and devising structures for bridging, as compared with that in the nonintervention groups. However, in studies comparing results with autologous nerve grafting, reports have indicated that bridging with artificial material is difficult to compare with autologous nerve grafting.…”

Section: Tubulization In the Critical Gapmentioning

confidence: 99%

Differentiated adipose‐derived stem cells promote peripheral nerve regeneration

et al. 2020

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Introduction Many reports have indicated that adipose‐derived stem cells (ADSCs) are effective for nerve regeneration. We investigated nerve regeneration by combining a polyglycolic acid collagen (PGA‐c) tube, which is approved for clinical use, and Schwann cell‐like differentiated ADSCs (dADSCs). Methods Fifteen‐millimeter‐long gaps in the sciatic nerve of rats were bridged in each group using tubes (group I), with tubes injected with dADSCs (group II), or by resected nerve (group III). Results Axonal outgrowth was greater in group II than in group I. Tibialis anterior muscle weight revealed recovery only in group III. Latency in nerve conduction studies was equivalent in group II and III, but action potential was lower in group II. Transplanted dADSCs maintained Schwann cell marker expression. ATF3 expression level in the dorsal root ganglia was equivalent in groups II and III. Discussion dADSCs maintained their differentiated state in the tubes and are believed to have contributed to nerve regeneration.

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Skin derived precursor Schwann cell-generated acellular matrix modified chitosan/silk scaffolds for bridging rat sciatic nerve gap

Zhu

Huang

Xue

et al. 2018

Neuroscience Research

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Il10 and poly‐dl‐lactide‐ɛ‐caprolactone conduits in critical size nerve defect bridging—An experimental study

Cited by 3 publications

References 50 publications

Application of marrow mesenchymal stem cell-derived extracellular matrix in peripheral nerve tissue engineering

Application of marrow mesenchymal stem cell-derived extracellular matrix in peripheral nerve tissue engineering

Differentiated adipose‐derived stem cells promote peripheral nerve regeneration

Skin derived precursor Schwann cell-generated acellular matrix modified chitosan/silk scaffolds for bridging rat sciatic nerve gap

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