Ilex paraguariensis extracts reduce blood glucose, peripheral neuropathy and oxidative damage in male mice exposed to streptozotocin

Lima, María Eduarda de; Colpo, Ana Zilda Ceolin; Rosa, Hemerson Silva da; Salgueiro, Andréia Caroline Fernandes; Silva, Marianne Pires da; Noronha, Dérick S.; Santamarı́a, Abel; Folmer, Vanderlei

doi:10.1016/j.jff.2018.02.024

Cited by 8 publications

(2 citation statements)

References 42 publications

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“…In this sense, lung cancer can damage nervous tissue and induce cell death during its evolution (Giglio & Gilbert, ), whereas polyphenols have a protective potential (Silva & Pogačnik, ), with chlorogenic acid antiapoptotic activity also having been reported (Anggreani & Lee, ). Moreover, this IP‐promoted neuroprotection agrees with other results already discussed, and with results found in another neuropathological model (De Lima et al, ).…”

Section: Discussionmentioning

confidence: 99%

Effects of bioavailable phenolic compounds from Ilex paraguariensis on the brain of mice with lung adenocarcinoma

Cittadini

Repossi

Albrecht

et al. 2019

Phytotherapy Research

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Lung carcinoma is one of the most common cancers and has a high mortality.Recently, we showed that it produces neurological paraneoplastic syndrome, with Ilex paraguariensis (IP) extract exerting palliative effects due to its content of phenolic compounds. It is possible, therefore, that these diet agents can arrive at the brain and exert neuroprotection, after the oral intake of IP. Here, the aim was to investigate the protective role of bioavailable IP compounds on the telencephalon and diencephalon in lung adenocarcinoma-bearing BALB/cJ males. Mice aged 2 months were treated for 3 weeks with 0-100 IP mg·kg −1 ·day −1 . HPLC-UV revealed the presence of chlorogenic acid and quercetin in brain regions, liver, and tumour, in an IP dosedependent manner. Brain was also evaluated histologically, and interleukin-6 was measured by ELISA. Chlorogenic acid was the major compound found in brain, whereas quercetin was observed at the diencephalon to a lesser extent. Both compounds were involved in IP dose-dependent diencephalic interleukin-6 reduction. Histology suggested cellular protection with less apoptosis in chlorogenic-exposed areas.Taken together, chlorogenic acid and quercetin from dietary IP were bioavailable and bioactive in brain, thereby attenuating lung cancer-related neuroinflammation and damage. These findings support plant-based strategies to improve prognosis. KEYWORDS chlorogenic acid, high performance liquid chromatography, interleukin-6, paraneoplastic syndrome, quercetin

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Section: Discussionmentioning

confidence: 99%

Effects of bioavailable phenolic compounds from Ilex paraguariensis on the brain of mice with lung adenocarcinoma

Cittadini

Repossi

Albrecht

et al. 2019

Phytotherapy Research

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“…Es bien sabido que la adopción de una dieta rica en antioxidantes naturales parece estar inversamente asociada con enfermedades crónicas degenerativas como las cardiovasculares, el cáncer, la obesidad y la diabetes, así como relacionada con la prevención de las implicaciones inflamatorias generales para la salud y la mejora de los lípidos en sangre, como el colesterol (Soukoulis et al, 2014). Una dieta rica en compuestos fenólicos está relacionada con un menor riesgo de múltiples enfermedades no transmisibles, como la diabetes tipo 2 y la aterosclerosis (de Lima et al, 2018;Granato et al, 2016;Santhakumar;Battino;Alvarez-Suarez, 2018). Algunos extractos vegetales ricos en compuestos antioxidantes han mostrado actividad antioxidante después de una digestión in vitro simulada, lo que evidencia su potencial para ser incorporados a los alimentos (Rashidinejad;Birch;Everett, 2015).…”

Section: Introductionunclassified

Capacidad antioxidante en helados y derivados lácteos

Campo-Banguero

Ramírez-Navas

2021

RCIA

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En la actualidad, se ha incrementado la tendencia global del consumo de alimentos o productos con potencial funcional de beneficiar a la salud humana. Gran parte de los compuestos bioactivos o ingredientes naturales empleados en los productos alimenticios funcionales derivan de plantas medicinales, frutas y vegetales. Una de las principales funciones reportadas es la disminución del riesgo de enfermedades degenerativas, que logra orientar las investigaciones, principalmente a la caracterización de componentes antioxidantes específicos. Por lo tanto, esta revisión se centra en exponer el poder antioxidante de compuestos bioactivos e ingredientes funcionales que se utilizan en algunos derivados lácteos y helados, evidenciando sus beneficios sobre la salud humana a través de su aprovechamiento en productos alimenticios.

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The chemical and pharmacological basis of yerba maté (Ilex paraguariensis A.St.-Hil.) as potential therapy for type 2 diabetes and metabolic syndrome

Habtemariam

2019

Medicinal Foods as Potential Therapies for Type-2 Diabetes and Associated Diseases

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Ilex paraguariensis extracts reduce blood glucose, peripheral neuropathy and oxidative damage in male mice exposed to streptozotocin

Cited by 8 publications

References 42 publications

Effects of bioavailable phenolic compounds from Ilex paraguariensis on the brain of mice with lung adenocarcinoma

Effects of bioavailable phenolic compounds from Ilex paraguariensis on the brain of mice with lung adenocarcinoma

Capacidad antioxidante en helados y derivados lácteos

The chemical and pharmacological basis of yerba maté (Ilex paraguariensis A.St.-Hil.) as potential therapy for type 2 diabetes and metabolic syndrome

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