Fairness in policing, driven by the effective and transparent investigation and remediation of police misconduct, is vital to maintaining the legitimacy of policing agencies, and the capacity for police to function within society. Research into police misconduct in Australia has traditionally been performed on an ad-hoc basis, with limited access to law enforcement data. This research seeks to identify the antecedents of serious police misconduct, resulting in the dismissal or criminal charge of officers, among a large police misconduct dataset. Demographic and misconduct data were sourced for a sample of 600 officers who have committed instances of serious misconduct, and a matched sample of 600 comparison officers across a 13-year period. A machine learning analysis, random forest, was utilised to produce a robust predictive model, with Partial Dependence Plots employed to demonstrate within variable interaction with serious misconduct. Prior instances of serious misconduct were particularly predictive of further serious misconduct, while misconduct was most prominent around mid-career. Secondary employment, and performance issues were important predictors, while demographic variables typically outperformed complaint variables. This research suggests that serious misconduct is similarly prevalent among experienced officers, as it is junior officers, while secondary employment is an important indicator of misconduct risk. Findings provide guidance for misconduct prevention policy among policing agencies.