"Illicit Transport" Systems for Organophosphorus Antimetabolites

Sheikh, M. Saeed; Gotlinsky, Barry; Tropp, Burton E.; Engel, Robert; Parker, T.E.

doi:10.1021/bk-1981-0171.ch046

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2 Nucleophilic Phosphorylation1

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“…The attachment of an amino acid or small peptide to a weakly active substance is a well-established method for enhancing its transport through cell membranes , or into tissues and, consequently, improving its activity. Phosphono peptides may display their activity in the intact form, or alternatively, they may serve as carriers of active aminophosphonates into plant tissues.…”

Section: 2 Nucleophilic Phosphorylationmentioning

confidence: 99%