Im Kampf gegen Krebs: Polyoxometallate als nächste Generation metallhaltiger Medikamente

Abstract

Polyoxometallate (POMs) haben großes Potenzial, verschiedene Tumorarten zu inhibieren; ihre Toxizität und unspezifischen Wechselwirkungen mit Biomolekülen verhindern jedoch eine klinische Anwendung. Der Schwerpunkt bei biologisch aktiven POMs liegt gegenwärtig auf organisch funktionalisierten POMs und POM‐basierten Nanokomposit‐Strukturen, da diese Hybride eine erhöhte Aktivität gegen Tumoren aufweisen, bei einer gleichzeitig deutlich verringerten Toxizität gegen normale Zellen. Während die Antitumoraktivität von POMs ausreichend beschrieben ist, sind ihre Wirkungsmechanismen noch weitgehend unbekannt. Dieser Aufsatz gibt einen Überblick über die zytotoxischen Effekte von POMs, wobei der Schwerpunkt auf POM‐basierten Hybriden und Nanokomposit‐Strukturen liegen soll. Postulierte Wirkungsmechanismen werden vorgestellt und molekulare Targets identifiziert. POMs könnten sich zur nächsten Generation metallhaltiger Krebsmedikamente entwickeln, die selektiv nur Krebszellen angreifen und gesunde Zellen verschonen.

Polyoxometalates: more than a phasing tool in protein crystallography

“…They exhibit an overwhelming diversity in size and structure with outstanding properties and functions [ 32 ]. POMs have been studied vigorously leading to their application in many fields like catalysis [ 33 ], nanoscience [ 34 ], medicine [ 35 – 40 ] and recently macromolecular crystallography [ 41 , 42 ]. POMs comprise isopolyanions and heteropolyanions exhibiting the general formula [M m O y ] n − and [X x M m O y ] n − , respectively.…”

Aluminum-Substituted Keggin Germanotungstate [HAl(H2O)GeW11O39]4–: Synthesis, Characterization, and Antibacterial Activity

“…Polyoxometalates (POMs) 1 represent a broad class of anionic inorganic clusters with versatile structural topologies resulting in a variety of chemical and physical properties that can be modulated by molecular design. These features make them attractive materials in a wide range of fields like catalysis, 2 electrochemistry, 3 magnetochemistry, 4 and biological chemistry 5 including protein crystallography. 6 Among the variety of POMs reported to date, Keggin-type POMs represent the largest family.…”

“…Because of their high negative charge, strong acidity, and geometry, POMs offer alternative modes of antimicrobial action by exhibiting synergy with some conventional antibiotics or direct antibacterial activity against both Gram-negative and Gram-positive bacteria. 5 , 9 Only a few all-inorganic POMs have been shown to exhibit antibacterial activity ( Table S2 ) on their own accord 5 despite their higher water solubility, which would make them more attractive for application in biological systems compared to their hybridized counterparts. Herein, we report the synthesis and thorough characterization of a new monosubstituted Keggin-type germanotungstate, (C 4 H 12 N) 4 [HAl III GeW 11 O 39 (H 2 O)]·11H 2 O ( [Al(H 2 O)GeW 11 ] 4– ), which was subjected to an antibacterial study.…”

Selective Adsorption of Hemoglobin in Human Whole Blood with a Nickel Monosubstituted Silicotungstic Acid Hybrid

“… 1 , 2 Therefore, they have been widely used in many fields, such as drugs, catalysis, electrochemistry, photochromic, magnetism, and medicine, and have attracted the attention of researchers. 3 − 5 Moreover, the negative electricity and the oxygen atoms of POMs provide many effective binding sites for their interaction with proteins. For example, through electrostatic interactions between the protein and POMs, the POMs [Ce(α-PW 11 O 39 ) 2 ] 10– of the Keggin type can selectively hydrolyze lysozyme in egg white, the POMs of Zr IV -substituted Keggin, Wells-Dawson, and Lindqvist types can selectively hydrolyze myoglobin under mild acidic and neutral conditions.…”