Image-based carotid flow reconstruction: a comparison between MRI and ultrasound

Glor, Fadi; Ariff, Ben; Hughes, Alun D.; Crowe, Lindsey A.; Verdonck, Pascal; Barratt, Dean C.; Thom, Simon; Firmin, David N.; Xu, Xiao Yun

doi:10.1088/0967-3334/25/6/014

Cited by 56 publications

(43 citation statements)

References 49 publications

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“…1, left) of the left main coronary bifurcation was manufactured post-mortem in the Pathology Department of the Dr. C.J. Finlay Klinik, Havana, Cuba under a defined transmural pressure of 100 mmHg (13,330 Pa) in a specially constructed apparatus using the two-component polymer Technovit 7143 (Heraues Kulzer GmbH, Wehrheim, Germany). The apparatus and the procedure of the vessel casts fabrication were presented elsewhere in detail.…”

Section: Reconstruction and Fabrication Of The Original Phantom Modelmentioning

confidence: 99%

“…Considering regions with the low WSS, we assumed a threshold value of about 0.4-0.5 Pa, which separates the surface area in hemodynamically safe and regions at risk (below threshold value) for atherogenesis 13,14 (see ''Discussion'' section). The analysis shows that 54% of the LCA surface is at risk in the original geometry.…”

Section: Hemodynamicsmentioning

confidence: 99%

“…Additionally to the time-averaged WSS, other hemodynamic parameters of the near wall flow have been proposed for clinically oriented flow studies: the oscillatory shear index (OSI), the time-averaged wall shear stress gradient (both spatial (WSSG s ) and temporal (WSSG t )), the wall shear stress angle deviation (WSSAD), and the wall shear stress angle gradient (WSSAG). 13 Low WSS values (<0.4-0.5 Pa) 24 are known to stimulate a proatherogenic endothelial phenotype, whereas moderate (>1.5 Pa) 24 WSS induces endothelial quiescence and an athero-protective gene expression profile. The endothelium may be functionally impaired due to a low (below threshold) shear stress signal, or due to impossibility to realize a consistent shear stress signal direction (OSI threshold value) or possibly due to significant and sustained high WSSG values as it was proposed by Lei et al 21 Regions of high WSSG are linked to intimal hyperplasia, formation of atherosclerotic lesions inside the arteries, and increased vessel wall permeability.…”

Section: Hemodynamic Parameters and Their Link To Biological Aspectsmentioning

confidence: 99%

“…Most of these studies concerned the carotid artery bifurcations. 5, 13,14 Recently, we studied the influence of two imaging modalities: CT and MRI 16 on coronary flow-profiling. We found that both techniques show a good reproducibility of the original geometry and may be used for clinical studies of patient-specific profiling of clinically relevant hemodynamic parameters.…”

Section: Introductionmentioning

confidence: 99%

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Coronary Artery WSS Profiling Using a Geometry Reconstruction Based on Biplane Angiography

et al. 2009

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Computational fluid dynamics (CFD) methods based on three-dimensional (3D) vessel reconstructions have recently been shown to provide prognostically relevant hemodynamic data. However, the geometry reconstruction and the assessment of clinically relevant hemodynamic parameters may depend on the used imaging modality. In this study, the silicon model of the left coronary artery (LCA) was acquired with a biplane angiography. The geometry reconstruction was done using commercial CAAS 5.2 QCA 3D software and compared with an original geometry. The original model is an optically digitized post-mortem vessel cast. The biplane angiography reconstruction achieved a Hausdorff surface distance of 0.236 mm to the original geometry that is comparable with results obtained in our earlier study for computed tomography (CT) and magnetic resonance imaging (MRI) reconstructions. Steady flow simulations were performed with a commercial CFD program FLUENT. A comparison of the calculated wall shear stress (WSS) shows good correlation for histograms (r=0.97) and good agreement among the four modalities with a mean WSS of 0.65 Pa in the original model, of 0.68 Pa in the CT-based model, of 0.67 Pa in the MRI based model, and of 0.69 Pa in the biplane angiography-based model. We can conclude that the biplane angiography-based reconstructions can be used for the WSS profiling of the coronary arteries.

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Section: Reconstruction and Fabrication Of The Original Phantom Modelmentioning

confidence: 99%

Section: Hemodynamicsmentioning

confidence: 99%

Section: Hemodynamic Parameters and Their Link To Biological Aspectsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Coronary Artery WSS Profiling Using a Geometry Reconstruction Based on Biplane Angiography

et al. 2009

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“…This results in gene alterations which in turn causes structural changes of the endothelial cells. A detailed study [37] on flow in carotid arteries has determined some of the important hemodynamic factors (WSS, WSSG) by combining medical images (obtained using magnetic MRI and 3D ultrasound) with CFD simulations. Their results were closely in agreement with those of Malek et al [38], who showed that values of WSS below 0.4 N/m 2 are known to stimulate proatherogenic endothelial phenotype while WSS > 1.5 N/m 2 is found to induce endothelial quiescence.…”

Section: Wss Spatial Wssg and Atherosclerosismentioning

confidence: 99%

Blood Flow in an Out-of-Plane Aorto-left Coronary Sequential Bypass Graft

Sankaranarayanan

Ghista

Chua

et al. 2009

Computational Cardiovascular Mechanics

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Coronary artery bypass graft (CABG) is a major therapy for ischemic heart disease which if left untreated can progress to failure of the heart. Restenosis, a leading cause of CABG, can be correlated with the geometric configuration and the hemodynamics of the graft. In this chapter we use computational fluid dynamics (CFD) to investigate the hemodynamics in a 3D out-of-plane sequential bypass graft model. Using a finite volume approach, quasi-steady flow simulations are performed at mid-ejection and at mid-diastole. Plots of velocity vectors, wall shear stress (WSS), and spatial WSS gradient (WSSG) distribution are presented in the aorto-left coronary bypass graft domain. Simulation results reveal a more uniform WSS and spatial WSSG distribution in the side-to-side (sequential graft) anastomosis configuration over the end-to-side (multiple graft) anastomosis. Results for the multiple bypass graft model show the peak magnitudes of the spatial WSSG are higher compared to the sequential bypass graft model. These findings suggest that sequential bypass grafting may be preferable over multiple bypass grafting to avoid non-uniformities of WSS. IntroductionThe sequential coronary artery bypass grafting (CABG) technique, as described in early years [1,2], is a technique in which two or more coronary artery anastomoses are made with a single graft, usually the saphenous vein. The distal anastomosis is constructed in an end-to-side fashion, while the proximal anastomosis is constructed in a side-to-side fashion. The advantages of this technique over the single graft technique include fewer anastomoses and higher graft flow [3,4]. Higher patency rates have also been observed through post angiograms in the proximal side-to-side M. Sankaranarayanan (B) Mathematics,

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Quantification of near‐wall hemodynamic risk factors in large‐scale cerebral arterial trees

Ghaffari

Alaraj

et al. 2018

Numer Methods Biomed Eng

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Detailed hemodynamic analysis of blood flow in pathological segments close to aneurysm and stenosis has provided physicians with invaluable information about the local flow patterns leading to vascular disease. However, these diseases have both local and global effects on the circulation of the blood within the cerebral tree. The aim of this paper is to demonstrate the importance of extending subject-specific hemodynamic simulations to the entire cerebral arterial tree with hundreds of bifurcations and vessels, as well as evaluate hemodynamic risk factors and waveform shape characteristics throughout the cerebral arterial trees. Angioarchitecture and in vivo blood flow measurement were acquired from healthy subjects and in cases with symptomatic intracranial aneurysm and stenosis. A global map of cerebral arterial blood flow distribution revealed regions of low to high hemodynamic risk that may significantly contribute to the development of intracranial aneurysms or atherosclerosis. Comparison of pre-intervention and post-intervention of pathological cases further shows large angular phase shift (~33.8°), and an augmentation of the peak-diastolic velocity. Hemodynamic indexes of waveform analysis revealed on average a 16.35% reduction in the pulsatility index after treatment from lesion site to downstream distal vessels. The lesion regions not only affect blood flow streamlines of the proximal sites but also generate pulse wave shift and disturbed flow in downstream vessels. This network effect necessitates the use of large-scale simulation to visualize both local and global effects of pathological lesions.

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Image-based carotid flow reconstruction: a comparison between MRI and ultrasound

Cited by 56 publications

References 49 publications

Coronary Artery WSS Profiling Using a Geometry Reconstruction Based on Biplane Angiography

Coronary Artery WSS Profiling Using a Geometry Reconstruction Based on Biplane Angiography

Blood Flow in an Out-of-Plane Aorto-left Coronary Sequential Bypass Graft

Quantification of near‐wall hemodynamic risk factors in large‐scale cerebral arterial trees

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