Image-guided neural activity manipulation with a paramagnetic drug

Bricault, Sarah; Barandov, Ali; Harvey, P. K.; DeTienne, Elizabeth; Hai, Aviad; Jasanoff, Alan

doi:10.1038/s41467-019-13933-5

Cited by 14 publications

(12 citation statements)

References 12 publications

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“…Mn is also used for in vivo visualization of trans-synaptic spread . In the future, substances that combine the neural perturbation action and have intrinsic MRI visibility, such as a newly developed paramagnetic analog of muscimol, might be utilized (Bricault et al, 2020). Stereotaxic alignment.…”

Section: Box 1: Targeting Brain Regions For Perturbationmentioning

confidence: 99%

Combining Brain Perturbation and Neuroimaging in Non-human Primates

Klink¹,

jean-francois.aubry@espci.fr²,

Ferrera³

et al. 2020

Preprint

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Brain perturbation studies allow detailed causal inferences of behavioral and neural processes. Because the combination of brain perturbation methods and neural measurement techniques is inherently challenging, research in humans has predominantly focused on non-invasive, indirect brain perturbations, or neurological lesions. Non-human primates have been indispensable as a neurobiological system that is highly similar to humans while simultaneously being more experimentally tractable, allowing visualization of the functional and structural impact of systematic brain perturbation. This review considers the state-of-the-art in non-human primate brain perturbation with a focus on approaches that can be combined with neuroimaging. We consider both non-reversible (lesions) and reversible or temporary perturbations such as electrical, pharmacological, optical, optogenetic, chemogenetic, pathway-selective, and ultrasound based interference methods. Method-specific considerations from the research and development community are offered to facilitate research in this field and support further innovations. We conclude by identifying novel avenues for further research and innovation and by highlighting the clinical translational potential of the methods.

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Section: Box 1: Targeting Brain Regions For Perturbationmentioning

confidence: 99%

Combining Brain Perturbation and Neuroimaging in Non-human Primates

Klink¹,

jean-francois.aubry@espci.fr²,

Ferrera³

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…Although chemical neuromodulation methods are common in basic and translational research, the real‐time visualization of neuromodulatory agents in vivo remains challenging. [ 48 ] For example, imaging of the intracerebral fluid injection (as described above) is typically performed postmortem using standard histology techniques. This approach, however, is not suitable for tracking the delivery of fluid cargo in real time, nor can it ascertain the spatiotemporal kinetics of the infusion in intact animals.…”

Section: Resultsmentioning

confidence: 99%

Customizing MRI‐Compatible Multifunctional Neural Interfaces through Fiber Drawing

Antonini

Sahasrabudhe

Tabet

et al. 2021

Adv Funct Materials

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Fiber drawing enables scalable fabrication of multifunctional flexible fibers that integrate electrical, optical, and microfluidic modalities to record and modulate neural activity. Constraints on thermomechanical properties of materials, however, have prevented integrated drawing of metal electrodes with low‐loss polymer waveguides for concurrent electrical recording and optical neuromodulation. Here, two fabrication approaches are introduced: 1) an iterative thermal drawing with a soft, low melting temperature (Tm) metal indium, and 2) a metal convergence drawing with traditionally non‐drawable high Tm metal tungsten. Both approaches deliver multifunctional flexible neural interfaces with low‐impedance metallic electrodes and low‐loss waveguides, capable of recording optically‐evoked and spontaneous neural activity in mice over several weeks. These fibers are coupled with a light‐weight mechanical microdrive (1 g) that enables depth‐specific interrogation of neural circuits in mice following chronic implantation. Finally, the compatibility of these fibers with magnetic resonance imaging is demonstrated and they are applied to visualize the delivery of chemical payloads through the integrated channels in real time. Together, these advances expand the domains of application of the fiber‐based neural probes in neuroscience and neuroengineering.

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“…[46,47] Although chemical neuromodulation methods are common in basic and translational research, the real-time visualization of neuromodulatory agents in vivo remains challenging. [48] For example, imaging of the intracerebral fluid injection (as described above) is typically performed postmortem using standard histology techniques. This approach, however, is not suitable for tracking the delivery of fluid cargo in real time, nor can it ascertain the spatiotemporal kinetics of the infusion in intact animals.…”

Section: In Vivo Mri Imaging In the Presence Of The Multifunctional Fibersmentioning

confidence: 99%

“…This approach, however, is not suitable for tracking the delivery of fluid cargo in real time, nor can it ascertain the spatiotemporal kinetics of the infusion in intact animals. [48] Here, we leverage the MRI compatibility of our multifunctional fibers to visualize in real-time microliter scale infusions of a Gd 3+ -based contrast agent ProHance (0.01 mM) in a deep subcortical region of the rat brain. We infuse this contrast agent at a rate of 20 nL/s over a 10 min period while MRI images are captured at a sampling rate of 0.1 Hz.…”

Section: In Vivo Mri Imaging In the Presence Of The Multifunctional Fibersmentioning

confidence: 99%

Customizing Multifunctional Neural Interfaces through Thermal Drawing Process

Antonini

Sahasrabudhe

Tabet

et al. 2021

Preprint

Self Cite

View full text Add to dashboard Cite

Fiber drawing enables scalable fabrication of multifunctional flexible fibers that integrate electrical, optical and microfluidic modalities to record and modulate neural activity. Constraints on thermomechanical properties of materials, however, have prevented integrated drawing of metal electrodes with low-loss polymer waveguides for concurrent electrical recording and optical neuromodulation. Here we introduce two fabrication approaches: (1) an iterative thermal drawing with a soft, low melting temperature (Tm) metal indium, and (2) a metal convergence drawing with traditionally non-drawable high Tm metal tungsten. Both approaches deliver multifunctional flexible neural interfaces with low-impedance metallic electrodes and low-loss waveguides, capable of recording optically-evoked and spontaneous neural activity in mice over several weeks. We couple these fibers with a light-weight mechanical microdrive (1g) that enables depth-specific interrogation of neural circuits in mice following chronic implantation. Finally, we demonstrate the compatibility of these fibers with magnetic resonance imaging (MRI) and apply them to visualize the delivery of chemical payloads through the integrated channels in real time. Together, these advances expand the domains of application of the fiber-based neural probes in neuroscience and neuroengineering.

show abstract

Image-guided neural activity manipulation with a paramagnetic drug

Cited by 14 publications

References 12 publications

Combining Brain Perturbation and Neuroimaging in Non-human Primates

Combining Brain Perturbation and Neuroimaging in Non-human Primates

Customizing MRI‐Compatible Multifunctional Neural Interfaces through Fiber Drawing

Customizing Multifunctional Neural Interfaces through Thermal Drawing Process

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