2002
DOI: 10.1016/s1076-6332(03)80194-0
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Image-Guided Percutaneous Thermal Ablation of Bone Tumors

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Cited by 62 publications
(34 citation statements)
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“…A large randomized, controlled, multicenter phase III trial has shown Focused Ultrasound (FUS) to be effective in the treatment of painful bone metastases [17], confirming results of earlier retrospective reports [18]. Small case series also support benefit from other percutaneous methods of image-guided ablation, including microwave ablation, laser ablation, and irreversible electroporation to treat skeletal metastases, although the data are more limited [19][20][21][22][23][24][25][26]. These studies demonstrate that multiple ablation therapies are effective at palliation of pain due to metastatic skeletal disease.…”
Section: Resultsmentioning
confidence: 59%
See 1 more Smart Citation
“…A large randomized, controlled, multicenter phase III trial has shown Focused Ultrasound (FUS) to be effective in the treatment of painful bone metastases [17], confirming results of earlier retrospective reports [18]. Small case series also support benefit from other percutaneous methods of image-guided ablation, including microwave ablation, laser ablation, and irreversible electroporation to treat skeletal metastases, although the data are more limited [19][20][21][22][23][24][25][26]. These studies demonstrate that multiple ablation therapies are effective at palliation of pain due to metastatic skeletal disease.…”
Section: Resultsmentioning
confidence: 59%
“…Each treatment modality has its advantages and disadvantages, and the choice of ablation technology typically depends on several factors, including interventional rradiologist preference and local expertise [23]. In our study the modality of choice was RFA due to availability, cost and expertise.…”
Section: Resultsmentioning
confidence: 96%
“…Moreover, external-beam radiation cannot reach the dose for killing the bone tumor because of nearby vital organs. Previously, multiple minimally invasive imageguided ablation strategies have been studied as treatments for painful bone metastases [23,24]. Cryoablation and RF ablation have been the most studied techniques demonstrating significantly reduced pain in patients who are unresponsive or incompletely responsive to standard conventional therapies.…”
Section: Discussionmentioning
confidence: 99%
“…24 The term "ablation" refers to the local destruction of the tumour by means of local deposition of some form of energy [radiofrequency (RF), laser, microwave, ultrasound and cryoablation]. [24][25][26] The aim of these techniques is to provide reduction of pain and improvement of the quality of life. They are performed under strict sterile conditions.…”
Section: Percutaneous Techniques Of Ablation In Metastasesmentioning
confidence: 99%
“…The current causes frictional heating and cell death through coagulative necrosis. 25 The mechanisms of action responsible for decreased pain include either direct destruction of sensory nerve fibres in the bone surrounding the metastasis or their decreased stimulation by reduction of the tumoural volume. Destruction of tumour cells that produce nerve-stimulating cytokines [such as tumour necrosis factor-a (TNF-a)] and inhibition of osteoclast activity are also incriminated.…”
Section: Radiofrequency Ablation Indicationsmentioning
confidence: 99%